| Inbound Relationships | Type | Active | Source | Characteristic | Refinability | Group | 
| Mutilating keratoderma | Is a | True | Rough skin of hands | Inferred relationship | Existential restriction modifier |  | 
| Keratoderma areata | Is a | False | Rough skin of hands | Inferred relationship | Existential restriction modifier |  | 
| Congenital palmoplantar and perioral keratoderma of Olmsted | Is a | False | Rough skin of hands | Inferred relationship | Existential restriction modifier |  | 
| Keratoderma with pachyonychia congenita | Is a | False | Rough skin of hands | Inferred relationship | Existential restriction modifier |  | 
| Palmoplantar hyperkeratosis sclerodactyly syndrome | Is a | True | Rough skin of hands | Inferred relationship | Existential restriction modifier |  | 
| Cerebral dysgenesis, neuropathy, ichthyosis, palmoplantar keratoderma syndrome | Is a | True | Rough skin of hands | Inferred relationship | Existential restriction modifier |  | 
| Skin fragility, wooly hair, palmoplantar keratoderma syndrome | Is a | True | Rough skin of hands | Inferred relationship | Existential restriction modifier |  | 
| Focal palmoplantar keratoderma with joint keratoses | Is a | True | Rough skin of hands | Inferred relationship | Existential restriction modifier |  | 
| Diffuse palmoplantar keratoderma with painful fissures | Is a | True | Rough skin of hands | Inferred relationship | Existential restriction modifier |  | 
| Autosomal dominant focal non-epidermolytic palmoplantar keratoderma with plantar blistering | Is a | True | Rough skin of hands | Inferred relationship | Existential restriction modifier |  | 
| Palmoplantar keratoderma, spastic paralysis syndrome | Is a | True | Rough skin of hands | Inferred relationship | Existential restriction modifier |  | 
| Leukoencephalopathy, palmoplantar keratoderma syndrome | Is a | True | Rough skin of hands | Inferred relationship | Existential restriction modifier |  | 
| Corneal intraepithelial dyskeratosis, palmoplantar hyperkeratosis, laryngeal dyskeratosis syndrome | Is a | True | Rough skin of hands | Inferred relationship | Existential restriction modifier |  | 
| Keratosis linearis, ichthyosis congenita, sclerosing keratoderma syndrome | Is a | True | Rough skin of hands | Inferred relationship | Existential restriction modifier |  | 
| Spastic paraplegia, intellectual disability, palmoplantar hyperkeratosis syndrome | Is a | True | Rough skin of hands | Inferred relationship | Existential restriction modifier |  | 
| Knuckle pads, leukonychia, sensorineural deafness, palmoplantar hyperkeratosis syndrome | Is a | True | Rough skin of hands | Inferred relationship | Existential restriction modifier |  | 
| Peeling skin, leukonychia, acral punctate keratoses, cheilitis, knuckle pads syndrome | Is a | True | Rough skin of hands | Inferred relationship | Existential restriction modifier |  |