| Inbound Relationships | Type | Active | Source | Characteristic | Refinability | Group | 
| Formyltetrahydrofolate deformylase | Is a | True | Substance with hydrolase mechanism of action | Inferred relationship | Existential restriction modifier |  | 
| Inorganic pyrophosphatase | Is a | True | Substance with hydrolase mechanism of action | Inferred relationship | Existential restriction modifier |  | 
| Lysosomal enzyme | Is a | True | Substance with hydrolase mechanism of action | Inferred relationship | Existential restriction modifier |  | 
| Extended-spectrum beta lactamase | Is a | True | Substance with hydrolase mechanism of action | Inferred relationship | Existential restriction modifier |  | 
| Beta-N-acetylhexosaminidase A | Is a | True | Substance with hydrolase mechanism of action | Inferred relationship | Existential restriction modifier |  | 
| Beta-N-acetylhexosaminidase B | Is a | True | Substance with hydrolase mechanism of action | Inferred relationship | Existential restriction modifier |  | 
| Beta-N-acetylhexosaminidase I | Is a | True | Substance with hydrolase mechanism of action | Inferred relationship | Existential restriction modifier |  | 
| Sulfatase | Is a | True | Substance with hydrolase mechanism of action | Inferred relationship | Existential restriction modifier |  | 
| Thymidine-triphosphatase | Is a | True | Substance with hydrolase mechanism of action | Inferred relationship | Existential restriction modifier |  | 
| Type I site-specific deoxyribonuclease | Is a | True | Substance with hydrolase mechanism of action | Inferred relationship | Existential restriction modifier |  | 
| Fructan beta-fructosidase | Is a | True | Substance with hydrolase mechanism of action | Inferred relationship | Existential restriction modifier |  | 
| Pancreatic ribonuclease | Is a | True | Substance with hydrolase mechanism of action | Inferred relationship | Existential restriction modifier |  | 
| Palmitoyl-coenzyme A hydrolase | Is a | True | Substance with hydrolase mechanism of action | Inferred relationship | Existential restriction modifier |  | 
| Xylan endo-1,3-beta-xylosidase | Is a | True | Substance with hydrolase mechanism of action | Inferred relationship | Existential restriction modifier |  | 
| Galacturan 1,4-alpha-galacturonidase | Is a | True | Substance with hydrolase mechanism of action | Inferred relationship | Existential restriction modifier |  | 
| Glucan endo-1,6-beta-glucosidase | Is a | True | Substance with hydrolase mechanism of action | Inferred relationship | Existential restriction modifier |  | 
| Mannan 1,4-beta-mannobiosidase | Is a | True | Substance with hydrolase mechanism of action | Inferred relationship | Existential restriction modifier |  | 
| Cathepsin R | Is a | False | Substance with hydrolase mechanism of action | Inferred relationship | Existential restriction modifier |  | 
| Renin | Is a | True | Substance with hydrolase mechanism of action | Inferred relationship | Existential restriction modifier |  | 
| Allantoinase | Is a | True | Substance with hydrolase mechanism of action | Inferred relationship | Existential restriction modifier |  | 
| Kynureninase | Is a | True | Substance with hydrolase mechanism of action | Inferred relationship | Existential restriction modifier |  | 
| Flaviastase | Is a | True | Substance with hydrolase mechanism of action | Inferred relationship | Existential restriction modifier |  | 
| alpha-Glucosidase (substance) | Is a | False | Substance with hydrolase mechanism of action | Inferred relationship | Existential restriction modifier |  | 
| Disaccharidase | Is a | True | Substance with hydrolase mechanism of action | Inferred relationship | Existential restriction modifier |  | 
| Lipase | Is a | False | Substance with hydrolase mechanism of action | Inferred relationship | Existential restriction modifier |  | 
| Gamma-cystathionase | Is a | False | Substance with hydrolase mechanism of action | Inferred relationship | Existential restriction modifier |  | 
| Multiple lysosomal hydrolases | Is a | True | Substance with hydrolase mechanism of action | Inferred relationship | Existential restriction modifier |  | 
| Fumarase | Is a | False | Substance with hydrolase mechanism of action | Inferred relationship | Existential restriction modifier |  | 
| Alpha-L-iduronidase | Is a | False | Substance with hydrolase mechanism of action | Inferred relationship | Existential restriction modifier |  | 
| 5-oxoprolinase | Is a | True | Substance with hydrolase mechanism of action | Inferred relationship | Existential restriction modifier |  | 
| Inosine triphosphate pyrophosphohydrolase | Is a | True | Substance with hydrolase mechanism of action | Inferred relationship | Existential restriction modifier |  | 
| S-Adenosyl homocysteine hydrolase | Is a | True | Substance with hydrolase mechanism of action | Inferred relationship | Existential restriction modifier |  | 
| Glycopeptide alpha-N-acetylgalactosaminidase | Is a | True | Substance with hydrolase mechanism of action | Inferred relationship | Existential restriction modifier |  | 
| Acylsphingosine deacylase | Is a | False | Substance with hydrolase mechanism of action | Inferred relationship | Existential restriction modifier |  | 
| Substance with serine protease mechanism of action | Is a | False | Substance with hydrolase mechanism of action | Inferred relationship | Existential restriction modifier |  | 
| Prorenin | Is a | True | Substance with hydrolase mechanism of action | Inferred relationship | Existential restriction modifier |  | 
| Elastase | Is a | False | Substance with hydrolase mechanism of action | Inferred relationship | Existential restriction modifier |  | 
| Bis (5'-guanosyl) tetraphosphatase | Is a | True | Substance with hydrolase mechanism of action | Inferred relationship | Existential restriction modifier |  | 
| Galactosidase | Is a | True | Substance with hydrolase mechanism of action | Inferred relationship | Existential restriction modifier |  | 
| Deaminase | Is a | True | Substance with hydrolase mechanism of action | Inferred relationship | Existential restriction modifier |  | 
| Hydratase | Is a | True | Substance with hydrolase mechanism of action | Inferred relationship | Existential restriction modifier |  | 
| Mannosidase | Is a | True | Substance with hydrolase mechanism of action | Inferred relationship | Existential restriction modifier |  | 
| Fucosidase | Is a | True | Substance with hydrolase mechanism of action | Inferred relationship | Existential restriction modifier |  | 
| Cerebrosidase | Is a | True | Substance with hydrolase mechanism of action | Inferred relationship | Existential restriction modifier |  | 
| Uridine monophosphate hydrolase | Is a | True | Substance with hydrolase mechanism of action | Inferred relationship | Existential restriction modifier |  | 
| Serratia marcescans nuclease | Is a | False | Substance with hydrolase mechanism of action | Inferred relationship | Existential restriction modifier |  | 
| Prenyl-pyrophosphatase | Is a | True | Substance with hydrolase mechanism of action | Inferred relationship | Existential restriction modifier |  | 
| Glycerol-1,2-cyclic-phosphate 2-phosphodiesterase | Is a | True | Substance with hydrolase mechanism of action | Inferred relationship | Existential restriction modifier |  | 
| Pentanamidase | Is a | True | Substance with hydrolase mechanism of action | Inferred relationship | Existential restriction modifier |  | 
| Lysozyme | Is a | True | Substance with hydrolase mechanism of action | Inferred relationship | Existential restriction modifier |  | 
| Amidinoaspartase | Is a | True | Substance with hydrolase mechanism of action | Inferred relationship | Existential restriction modifier |  | 
| Pectinesterase | Is a | True | Substance with hydrolase mechanism of action | Inferred relationship | Existential restriction modifier |  | 
| Ficin | Is a | True | Substance with hydrolase mechanism of action | Inferred relationship | Existential restriction modifier |  | 
| Peptidoglycan beta-N-acetylmuramidase | Is a | True | Substance with hydrolase mechanism of action | Inferred relationship | Existential restriction modifier |  | 
| Adenylylsulfatase | Is a | True | Substance with hydrolase mechanism of action | Inferred relationship | Existential restriction modifier |  | 
| Oxyuranus scutellotus prothrombin-activating proteinase | Is a | True | Substance with hydrolase mechanism of action | Inferred relationship | Existential restriction modifier |  | 
| Cyclomaltodextrinase | Is a | True | Substance with hydrolase mechanism of action | Inferred relationship | Existential restriction modifier |  | 
| Adenosine-tetraphosphatase | Is a | True | Substance with hydrolase mechanism of action | Inferred relationship | Existential restriction modifier |  | 
| Adenosine diphosphate sugar pyrophosphatase | Is a | True | Substance with hydrolase mechanism of action | Inferred relationship | Existential restriction modifier |  | 
| Mycodextranase | Is a | True | Substance with hydrolase mechanism of action | Inferred relationship | Existential restriction modifier |  | 
| 6-aminohexanoate-cyclic-dimer hydrolase | Is a | True | Substance with hydrolase mechanism of action | Inferred relationship | Existential restriction modifier |  | 
| 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase | Is a | True | Substance with hydrolase mechanism of action | Inferred relationship | Existential restriction modifier |  | 
| Deoxyribonuclease IV (Phage T>4<-induced) | Is a | False | Substance with hydrolase mechanism of action | Inferred relationship | Existential restriction modifier |  | 
| Aminoacyl-histidine dipeptidase | Is a | True | Substance with hydrolase mechanism of action | Inferred relationship | Existential restriction modifier |  | 
| Cathepsin D | Is a | False | Substance with hydrolase mechanism of action | Inferred relationship | Existential restriction modifier |  | 
| Deoxylimonate A-ring-lactonase | Is a | True | Substance with hydrolase mechanism of action | Inferred relationship | Existential restriction modifier |  | 
| Glucan 1,3-beta-glucosidase | Is a | True | Substance with hydrolase mechanism of action | Inferred relationship | Existential restriction modifier |  | 
| Exo-poly-alpha-galacturonosidase | Is a | True | Substance with hydrolase mechanism of action | Inferred relationship | Existential restriction modifier |  | 
| Ribonuclease T>1< | Is a | True | Substance with hydrolase mechanism of action | Inferred relationship | Existential restriction modifier |  | 
| Amidase | Is a | True | Substance with hydrolase mechanism of action | Inferred relationship | Existential restriction modifier |  | 
| D-arabinonolactonase | Is a | True | Substance with hydrolase mechanism of action | Inferred relationship | Existential restriction modifier |  | 
| Ribonuclease IV | Is a | True | Substance with hydrolase mechanism of action | Inferred relationship | Existential restriction modifier |  | 
| Nicotinamide adenine dinucleotide (phosphate) ^+^ nucleosidase | Is a | True | Substance with hydrolase mechanism of action | Inferred relationship | Existential restriction modifier |  | 
| Asparaginase | Is a | False | Substance with hydrolase mechanism of action | Inferred relationship | Existential restriction modifier |  | 
| Oxaloacetase | Is a | True | Substance with hydrolase mechanism of action | Inferred relationship | Existential restriction modifier |  | 
| Beta-L-rhamnosidase | Is a | True | Substance with hydrolase mechanism of action | Inferred relationship | Existential restriction modifier |  | 
| w-Amidase | Is a | True | Substance with hydrolase mechanism of action | Inferred relationship | Existential restriction modifier |  | 
| Cellulose 1,4-beta-cellobiosidase | Is a | True | Substance with hydrolase mechanism of action | Inferred relationship | Existential restriction modifier |  | 
| Alpha,alpha-phosphotrehalase | Is a | True | Substance with hydrolase mechanism of action | Inferred relationship | Existential restriction modifier |  | 
| Formylmethionine deformylase | Is a | True | Substance with hydrolase mechanism of action | Inferred relationship | Existential restriction modifier |  | 
| Endogalactosaminidase | Is a | True | Substance with hydrolase mechanism of action | Inferred relationship | Existential restriction modifier |  | 
| Phosphoribosyl-adenosine monophosphate cyclohydrolase | Is a | True | Substance with hydrolase mechanism of action | Inferred relationship | Existential restriction modifier |  | 
| Urease | Is a | True | Substance with hydrolase mechanism of action | Inferred relationship | Existential restriction modifier |  | 
| N-Acetylglucosamine-6-phosphate deacetylase | Is a | True | Substance with hydrolase mechanism of action | Inferred relationship | Existential restriction modifier |  | 
| Aminoacyl-transfer ribonucleic acid hydrolase | Is a | True | Substance with hydrolase mechanism of action | Inferred relationship | Existential restriction modifier |  | 
| Choloylglycine hydrolase | Is a | True | Substance with hydrolase mechanism of action | Inferred relationship | Existential restriction modifier |  | 
| Glucan 1,4-alpha-maltotetraohydrolase | Is a | True | Substance with hydrolase mechanism of action | Inferred relationship | Existential restriction modifier |  | 
| Isopullulanase | Is a | True | Substance with hydrolase mechanism of action | Inferred relationship | Existential restriction modifier |  | 
| Beta-glucosidase | Is a | False | Substance with hydrolase mechanism of action | Inferred relationship | Existential restriction modifier |  | 
| Endopolyphosphatase | Is a | True | Substance with hydrolase mechanism of action | Inferred relationship | Existential restriction modifier |  | 
| Limonin-D-ring-lactonase | Is a | True | Substance with hydrolase mechanism of action | Inferred relationship | Existential restriction modifier |  | 
| Sinapine esterase | Is a | True | Substance with hydrolase mechanism of action | Inferred relationship | Existential restriction modifier |  | 
| Guanidinobutyrase | Is a | True | Substance with hydrolase mechanism of action | Inferred relationship | Existential restriction modifier |  | 
| Sporotrichum proteinase II | Is a | False | Substance with hydrolase mechanism of action | Inferred relationship | Existential restriction modifier |  | 
| Cathepsin G | Is a | False | Substance with hydrolase mechanism of action | Inferred relationship | Existential restriction modifier |  | 
| K-Carrageenase | Is a | True | Substance with hydrolase mechanism of action | Inferred relationship | Existential restriction modifier |  | 
| Phorbol-diester hydrolase | Is a | True | Substance with hydrolase mechanism of action | Inferred relationship | Existential restriction modifier |  | 
| Ribosylpyrimidine nucleosidase | Is a | True | Substance with hydrolase mechanism of action | Inferred relationship | Existential restriction modifier |  | 
| Na^+^/K^+^-transporting adenosine triphosphatase | Is a | True | Substance with hydrolase mechanism of action | Inferred relationship | Existential restriction modifier |  | 
| Dihydrocoumarin hydrolase | Is a | True | Substance with hydrolase mechanism of action | Inferred relationship | Existential restriction modifier |  | 
| Histidine ammonia-lyase | Is a | True | Substance with hydrolase mechanism of action | Inferred relationship | Existential restriction modifier |  |