| Inbound Relationships | Type | Active | Source | Characteristic | Refinability | Group | 
| Tumor stage T4a | Is a | False | T4 category | Inferred relationship | Existential restriction modifier |  | 
| Tumor stage T4b | Is a | False | T4 category | Inferred relationship | Existential restriction modifier |  | 
| Tumor stage T4c | Is a | False | T4 category | Inferred relationship | Existential restriction modifier |  | 
| Tumor stage T4d | Is a | False | T4 category | Inferred relationship | Existential restriction modifier |  | 
| Tumor-node-metastasis (TNM) pancreas tumor staging | Stage | False | T4 category | Inferred relationship | Existential restriction modifier |  | 
| T4 (IVA): Tumor of uterine cervix/vagina invades mucosa of bladder or rectum and/or extends beyond true pelvis | Is a | False | T4 category | Inferred relationship | Existential restriction modifier |  | 
| T4 (IVA): Endometrial tumor invades bladder mucosa and/or bowel mucosa | Is a | False | T4 category | Inferred relationship | Existential restriction modifier |  | 
| T4: Lip: Tumor invades adjacent structures (cortical bone, inferior alveolar nerve, floor of mouth, skin of face) | Is a | False | T4 category | Inferred relationship | Existential restriction modifier |  | 
| T4: Oral Cavity: Tumor invades adjacent structures (cortical bone, deep (extrinsic) muscle of tongue, maxillary sinus, skin) | Is a | False | T4 category | Inferred relationship | Existential restriction modifier |  | 
| T4: Aerodigestive tract tumor invades adjacent structures (pterygoid muscles, mandible, hard palate, deep muscle of tongue, larynx) | Is a | False | T4 category | Inferred relationship | Existential restriction modifier |  | 
| T4: Aerodigestive tract tumor invades adjacent structures (thyroid/cricoid cartilage, carotid artery, soft tissues of neck, prevertebral fascia/muscles, thyroid and/or esophagus) | Is a | False | T4 category | Inferred relationship | Existential restriction modifier |  | 
| T4: Aerodigestive tumor invades base of skull, seventh nerve, and/or exceeds 6 cm in greatest dimension | Is a | False | T4 category | Inferred relationship | Existential restriction modifier |  | 
| T4: Aerodigestive tract tumor invades orbital contents beyond the floor or medial wall including apex and/or any of the following: cribriform plate, base of skull, nasopharynx, sphenoid sinus, frontal sinus | Is a | False | T4 category | Inferred relationship | Existential restriction modifier |  | 
| T4: Tumor invades through cricoid or thyroid cartilage and/or extends into other tissues beyond the larynx (trachea, soft tissues of neck, thyroid, esophagus) | Is a | False | T4 category | Inferred relationship | Existential restriction modifier |  | 
| T4: Tumor invades through thyroid cartilage and/or extends to other tissues beyond the larynx (trachea, soft tissues of neck, pharynx) | Is a | False | T4 category | Inferred relationship | Existential restriction modifier |  | 
| T4: Tumor invades through thyroid cartilage, and/or extends into soft tissues of the neck, thyroid, and/or esophagus | Is a | False | T4 category | Inferred relationship | Existential restriction modifier |  | 
| T4: Aerodigestive tract tumor with intracranial extension and/or involvement of cranial nerves, infratemporal fossa, hypopharynx or orbit | Is a | False | T4 category | Inferred relationship | Existential restriction modifier |  | 
| T4: Aerodigestive tract tumor with intracranial extension, orbital extension including apex, involving sphenoid and/or frontal sinus and/or skin of nose | Is a | False | T4 category | Inferred relationship | Existential restriction modifier |  | 
| T4: Lung tumor of any size that invades any of the following: mediastinum; heart; great vessels; trachea; esophagus; vertebral body; carina | Is a | False | T4 category | Inferred relationship | Existential restriction modifier |  | 
| T4: Lung tumor of any size with a malignant pleural effusion | Is a | False | T4 category | Inferred relationship | Existential restriction modifier |  | 
| T4: Lung tumor of any size with separate tumor nodule(s) in same lobe | Is a | False | T4 category | Inferred relationship | Existential restriction modifier |  | 
| T4: Renal tumor invades beyond Gerota's fascia | Is a | False | T4 category | Inferred relationship | Existential restriction modifier |  | 
| T4: Breast tumor of any size with direct extension to chest wall or skin | Is a | False | T4 category | Inferred relationship | Existential restriction modifier |  | 
| T4a: Breast tumor with extension to chest wall | Is a | False | T4 category | Inferred relationship | Existential restriction modifier |  | 
| T4b: Edema (including peau d'orange) or ulceration of the skin of the breast or satellite skin nodules confined to the same breast | Is a | False | T4 category | Inferred relationship | Existential restriction modifier |  | 
| T4c: Breast tumor, both T4a and T4b | Is a | False | T4 category | Inferred relationship | Existential restriction modifier |  | 
| T4d: Inflammatory carcinoma (breast) | Is a | False | T4 category | Inferred relationship | Existential restriction modifier |  | 
| T4: Tumor directly invades adjacent structures | Is a | False | T4 category | Inferred relationship | Existential restriction modifier |  | 
| T4a: Colon/rectum tumor directly invades other organs or structures | Is a | False | T4 category | Inferred relationship | Existential restriction modifier |  | 
| T4b: Colon/rectum tumor penetrates the visceral peritoneum | Is a | False | T4 category | Inferred relationship | Existential restriction modifier |  | 
| T4: Ampulla tumor invades >2 cm into pancreas and/or into other adjacent organs | Is a | False | T4 category | Inferred relationship | Existential restriction modifier |  | 
| T4: Pancreas tumor extends directly to any of the following: stomach; spleen; colon; adjacent large vessels | Is a | False | T4 category | Inferred relationship | Existential restriction modifier |  | 
| T4: Urinary bladder tumor invades any of the following: prostate, uterus, vagina, pelvic wall abdominal wall | Is a | False | T4 category | Inferred relationship | Existential restriction modifier |  | 
| T4: Renal pelvis/ureter tumor invades adjacent organs, or through the kidney into the perinephric fat | Is a | False | T4 category | Inferred relationship | Existential restriction modifier |  | 
| T4a: Bladder tumor invades prostate or uterus or vagina | Is a | False | T4 category | Inferred relationship | Existential restriction modifier |  | 
| T4b: Bladder tumor invades pelvic wall or abdominal wall | Is a | False | T4 category | Inferred relationship | Existential restriction modifier |  | 
| T4: Testicular tumor invades scrotum with or without vascular/lymphatic invasion | Is a | False | T4 category | Inferred relationship | Existential restriction modifier |  | 
| T4: Pleural tumor directly extends to any of the following: contralateral pleura, contralateral lung, peritoneum, intra-abdominal organs, cervical tissues | Is a | False | T4 category | Inferred relationship | Existential restriction modifier |  | 
| T4: Thyroid tumor of any size extending beyond the thyroid capsule | Is a | False | T4 category | Inferred relationship | Existential restriction modifier |  | 
| pT4: Tumor invades adjacent structures (stomach) | Is a | False | T4 category | Inferred relationship | Existential restriction modifier |  | 
| pT4 category | Is a | False | T4 category | Inferred relationship | Existential restriction modifier |  |