| Inbound Relationships | Type | Active | Source | Characteristic | Refinability | Group | 
| pT4b: Tumor invades any of the following: orbital apex, dura, brain, middle cranial fossa, cranial nerves other than maxillary division of trigeminal nerve, nasopharynx, or clivus (maxillary sinus) | Is a | False | pT4b category | Inferred relationship | Existential restriction modifier |  | 
| pT4b: Tumor of any size with edema (including peau d'orange) or ulceration of the skin of the breast or satellite skin nodules confined to the same breast | Is a | False | pT4b category | Inferred relationship | Existential restriction modifier |  | 
| pT4b: Tumor invades deep extradermal structures (i.e. cartilage, skeletal muscle, or bone) greater than 6mm in thickness (carcinoma of skin excluding eyelid, vulva, penis, and melanomas) | Is a | False | pT4b category | Inferred relationship | Existential restriction modifier |  | 
| pT4b: Melanoma greater than 4.0 mm in thickness, with ulceration (melanoma of the skin) | Is a | False | pT4b category | Inferred relationship | Existential restriction modifier |  | 
| pT4b: Tumor invades pelvic wall or abdominal wall (urinary bladder) | Is a | False | pT4b category | Inferred relationship | Existential restriction modifier |  | 
| pT4b: Tumor invades prevertebral space, encases carotid artery, or invades mediastinal structures (larynx, supraglottis) | Is a | False | pT4b category | Inferred relationship | Existential restriction modifier |  | 
| pT4b: Tumor invades prevertebral space, encases carotid artery, or invades mediastinal structures (larynx, subglottis) | Is a | False | pT4b category | Inferred relationship | Existential restriction modifier |  | 
| pT4b: Tumor invades prevertebral fascia, encases carotid artery, or involves mediastinal structures (hypopharynx) | Is a | False | pT4b category | Inferred relationship | Existential restriction modifier |  | 
| pT4b: Tumor invades lateral pterygoid muscle, pterygoid plates, lateral nasopharynx, or skull base or encases internal carotid artery (oropharynx) | Is a | False | pT4b category | Inferred relationship | Existential restriction modifier |  | 
| pT4b: Tumor involves masticator space, pterygoid plates, or skull base and/or encases internal carotid artery (lip and oral cavity) | Is a | False | pT4b category | Inferred relationship | Existential restriction modifier |  | 
| pT4b: Tumor invades any of the following: orbital apex, dura, brain, middle cranial fossa, cranial nerves other than maxillary division of trigeminal nerve, nasopharynx, or clivus (nasal cavity and ethmoid sinus) | Is a | False | pT4b category | Inferred relationship | Existential restriction modifier |  | 
| pT4b: Extrathyroidal anaplastic carcinoma - surgically unresectable (anaplastic carcinoma) (thyroid) | Is a | False | pT4b category | Inferred relationship | Existential restriction modifier |  | 
| pT4b: Tumor penetrates visceral peritoneum (colon/rectum) | Is a | False | pT4b category | Inferred relationship | Existential restriction modifier |  | 
| pT4b: Tumor invades prevertebral fascia or encases carotid artery or mediastinal vessels (thyroid) | Is a | False | pT4b category | Inferred relationship | Existential restriction modifier |  | 
| pT4b: Tumor invades prevertebral space, encases carotid artery, or invades mediastinal structures (larynx, glottis) | Is a | False | pT4b category | Inferred relationship | Existential restriction modifier |  | 
| pT4b: Tumor invades skull base and/or pterygoid plates and/or encases carotid artery (major salivary glands) | Is a | False | pT4b category | Inferred relationship | Existential restriction modifier |  | 
| pT4b: Tumor invades lateral pterygoid muscle, pterygoid plates, lateral nasopharynx, or skull base or encases carotid artery (oropharynx) | Is a | False | pT4b category | Inferred relationship | Existential restriction modifier |  | 
| pT4b: Tumor directly invades or is adherent to other organs or structures (colon/rectum) | Is a | False | pT4b category | Inferred relationship | Existential restriction modifier |  |