| Inbound Relationships | Type | Active | Source | Characteristic | Refinability | Group | 
| Psychoactive substance of abuse - non-pharmaceutical | Is a | False | Psychoactive substance | Inferred relationship | Existential restriction modifier |  | 
| Central depressant | Is a | True | Psychoactive substance | Inferred relationship | Existential restriction modifier |  | 
| Cocaine | Is a | False | Psychoactive substance | Inferred relationship | Existential restriction modifier |  | 
| Psychotropic agent | Is a | True | Psychoactive substance | Inferred relationship | Existential restriction modifier |  | 
| Controlled drug dependence | Causative agent | False | Psychoactive substance | Inferred relationship | Existential restriction modifier |  | 
| Active drug dependence | Causative agent | False | Psychoactive substance | Inferred relationship | Existential restriction modifier |  | 
| Psychoactive substance use disorder | Causative agent | False | Psychoactive substance | Inferred relationship | Existential restriction modifier | 1 | 
| Psychoactive substance-induced organic dementia | Causative agent | False | Psychoactive substance | Inferred relationship | Existential restriction modifier | 3 | 
| Organic mental disorder caused by psychoactive substance | Causative agent | True | Psychoactive substance | Inferred relationship | Existential restriction modifier | 1 | 
| Sedative, hypnotic AND/OR anxiolytic-induced persisting amnestic disorder | Causative agent | False | Psychoactive substance | Inferred relationship | Existential restriction modifier |  | 
| Sedative, hypnotic AND/OR anxiolytic-related disorder | Causative agent | False | Psychoactive substance | Inferred relationship | Existential restriction modifier | 1 | 
| Organic mental disorder caused by hypnotic agent | Causative agent | False | Psychoactive substance | Inferred relationship | Existential restriction modifier |  | 
| Sedative, hypnotic AND/OR anxiolytic-induced anxiety disorder | Causative agent | False | Psychoactive substance | Inferred relationship | Existential restriction modifier | 1 | 
| Inhalant intoxication delirium | Causative agent | True | Psychoactive substance | Inferred relationship | Existential restriction modifier | 1 | 
| Sedative, hypnotic AND/OR anxiolytic-induced psychotic disorder with delusions | Causative agent | False | Psychoactive substance | Inferred relationship | Existential restriction modifier | 1 | 
| Inhalant-induced anxiety disorder | Causative agent | True | Psychoactive substance | Inferred relationship | Existential restriction modifier | 1 | 
| Psychoactive substance dependence | Causative agent | True | Psychoactive substance | Inferred relationship | Existential restriction modifier | 1 | 
| Organic hallucinosis caused by psychoactive substance | Causative agent | False | Psychoactive substance | Inferred relationship | Existential restriction modifier | 1 | 
| Sedative, hypnotic AND/OR anxiolytic-induced mood disorder | Causative agent | False | Psychoactive substance | Inferred relationship | Existential restriction modifier | 1 | 
| Nicotine-induced organic mental disorder | Causative agent | False | Psychoactive substance | Inferred relationship | Existential restriction modifier |  | 
| Organic delusional disorder caused by psychoactive substance | Causative agent | True | Psychoactive substance | Inferred relationship | Existential restriction modifier | 1 | 
| Inhalant-induced persisting dementia | Causative agent | False | Psychoactive substance | Inferred relationship | Existential restriction modifier | 3 | 
| Phencyclidine-induced psychotic disorder with hallucinations | Causative agent | False | Psychoactive substance | Inferred relationship | Existential restriction modifier | 1 | 
| Organic mood disorder caused by psychoactive substance | Causative agent | True | Psychoactive substance | Inferred relationship | Existential restriction modifier | 1 | 
| Psychoactive substance-induced organic delirium | Causative agent | True | Psychoactive substance | Inferred relationship | Existential restriction modifier | 1 | 
| Organic personality disorder caused by psychoactive substance | Causative agent | True | Psychoactive substance | Inferred relationship | Existential restriction modifier | 1 | 
| Sedative, hypnotic AND/OR anxiolytic-induced psychotic disorder with hallucinations | Causative agent | False | Psychoactive substance | Inferred relationship | Existential restriction modifier | 1 | 
| Organic anxiety disorder caused by psychoactive substance | Causative agent | False | Psychoactive substance | Inferred relationship | Existential restriction modifier | 3 | 
| Polysubstance dependence | Causative agent | False | Psychoactive substance | Inferred relationship | Existential restriction modifier |  | 
| Sedative, hypnotic AND/OR anxiolytic intoxication delirium | Causative agent | False | Psychoactive substance | Inferred relationship | Existential restriction modifier | 1 | 
| Nicotine dependence | Causative agent | False | Psychoactive substance | Inferred relationship | Existential restriction modifier |  | 
| Sedative, hypnotic AND/OR anxiolytic-induced sleep disorder | Causative agent | False | Psychoactive substance | Inferred relationship | Existential restriction modifier | 1 | 
| Sedative, hypnotic AND/OR anxiolytic-induced persisting dementia | Causative agent | False | Psychoactive substance | Inferred relationship | Existential restriction modifier | 2 | 
| Inhalant-induced organic mental disorder | Causative agent | True | Psychoactive substance | Inferred relationship | Existential restriction modifier | 1 | 
| Inhalant-induced psychotic disorder with hallucinations | Causative agent | True | Psychoactive substance | Inferred relationship | Existential restriction modifier | 1 | 
| Inhalant-induced psychotic disorder with delusions | Causative agent | True | Psychoactive substance | Inferred relationship | Existential restriction modifier | 1 | 
| Tobacco dependence syndrome | Causative agent | False | Psychoactive substance | Inferred relationship | Existential restriction modifier |  | 
| Drug dependence | Causative agent | False | Psychoactive substance | Inferred relationship | Existential restriction modifier |  | 
| Combined drug dependence, excluding opioids | Causative agent | False | Psychoactive substance | Inferred relationship | Existential restriction modifier |  | 
| Combined drug dependence, excluding opioid, continuous | Causative agent | False | Psychoactive substance | Inferred relationship | Existential restriction modifier |  | 
| Combined drug dependence, excluding opioid, episodic | Causative agent | False | Psychoactive substance | Inferred relationship | Existential restriction modifier |  | 
| Combined drug dependence, excluding opioid, in remission | Causative agent | False | Psychoactive substance | Inferred relationship | Existential restriction modifier |  | 
| Tobacco dependence, continuous | Causative agent | False | Psychoactive substance | Inferred relationship | Existential restriction modifier |  | 
| Tobacco dependence, episodic | Causative agent | False | Psychoactive substance | Inferred relationship | Existential restriction modifier |  | 
| Tobacco dependence in remission | Causative agent | False | Psychoactive substance | Inferred relationship | Existential restriction modifier |  | 
| Drug dependence during pregnancy - baby delivered | Causative agent | False | Psychoactive substance | Inferred relationship | Existential restriction modifier |  | 
| Drug dependence in the puerperium - baby delivered | Causative agent | False | Psychoactive substance | Inferred relationship | Existential restriction modifier |  | 
| Drug dependence during pregnancy - baby not yet delivered | Causative agent | False | Psychoactive substance | Inferred relationship | Existential restriction modifier |  | 
| Drug dependence in the puerperium - baby delivered during previous episode of care | Causative agent | False | Psychoactive substance | Inferred relationship | Existential restriction modifier |  | 
| Pregnancy and drug dependence | Causative agent | False | Psychoactive substance | Inferred relationship | Existential restriction modifier |  | 
| Drug dependence during pregnancy, childbirth and the puerperium | Causative agent | False | Psychoactive substance | Inferred relationship | Existential restriction modifier |  | 
| Cannabis type drug dependence | Causative agent | False | Psychoactive substance | Inferred relationship | Existential restriction modifier |  | 
| Amphetamine or psychostimulant dependence, unspecified | Causative agent | False | Psychoactive substance | Inferred relationship | Existential restriction modifier |  | 
| Amphetamine or psychostimulant dependence NOS | Causative agent | False | Psychoactive substance | Inferred relationship | Existential restriction modifier |  | 
| Other specified drug dependence, unspecified | Causative agent | False | Psychoactive substance | Inferred relationship | Existential restriction modifier |  | 
| Other specified drug dependence, continuous | Causative agent | False | Psychoactive substance | Inferred relationship | Existential restriction modifier |  | 
| Other specified drug dependence, episodic | Causative agent | False | Psychoactive substance | Inferred relationship | Existential restriction modifier |  | 
| Other specified drug dependence in remission | Causative agent | False | Psychoactive substance | Inferred relationship | Existential restriction modifier |  | 
| Other specified drug dependence NOS | Causative agent | False | Psychoactive substance | Inferred relationship | Existential restriction modifier |  | 
| Combined drug dependence, excluding opioid, unspecified | Causative agent | False | Psychoactive substance | Inferred relationship | Existential restriction modifier |  | 
| Combined drug dependence, excluding opioid, NOS | Causative agent | False | Psychoactive substance | Inferred relationship | Existential restriction modifier |  | 
| Drug dependence NOS | Causative agent | False | Psychoactive substance | Inferred relationship | Existential restriction modifier |  | 
| Tobacco dependence, unspecified | Causative agent | False | Psychoactive substance | Inferred relationship | Existential restriction modifier |  | 
| Tobacco dependence NOS | Causative agent | False | Psychoactive substance | Inferred relationship | Existential restriction modifier |  | 
| [X]Mental and behavioral disorders due to use of other stimulants, including caffeine | Causative agent | False | Psychoactive substance | Inferred relationship | Existential restriction modifier |  | 
| [X]Mental and behavioral disorders due to use of other stimulants, including caffeine: acute intoxication | Causative agent | False | Psychoactive substance | Inferred relationship | Existential restriction modifier |  | 
| [X]Mental and behavioral disorders due to use of other stimulants, including caffeine: harmful use | Causative agent | False | Psychoactive substance | Inferred relationship | Existential restriction modifier |  | 
| [X]Mental and behavioral disorders due to use of other stimulants, including caffeine: withdrawal state | Causative agent | False | Psychoactive substance | Inferred relationship | Existential restriction modifier |  | 
| [X]Mental and behavioral disorders due to use of other stimulants, including caffeine: withdrawal state with delirium | Causative agent | False | Psychoactive substance | Inferred relationship | Existential restriction modifier |  | 
| [X]Mental and behavioral disorders due to use of other stimulants, including caffeine: psychotic disorder | Causative agent | False | Psychoactive substance | Inferred relationship | Existential restriction modifier |  | 
| [X]Mental and behavioral disorders due to use of other stimulants, including caffeine: amnesic syndrome | Causative agent | False | Psychoactive substance | Inferred relationship | Existential restriction modifier |  | 
| [X]Mental and behavioral disorders due to use of other stimulants, including caffeine: residual and late-onset psychotic disorder | Causative agent | False | Psychoactive substance | Inferred relationship | Existential restriction modifier |  | 
| [X]Mental and behavioral disorders due to use of other stimulants, including caffeine: other mental and behavioral disorders | Causative agent | False | Psychoactive substance | Inferred relationship | Existential restriction modifier |  | 
| [X]Mental and behavioral disorders due to use of other stimulants, including caffeine: unspecified mental and behavioral disorder | Causative agent | False | Psychoactive substance | Inferred relationship | Existential restriction modifier |  | 
| Drug dependence - unspecified whether during pregnancy or the puerperium | Causative agent | False | Psychoactive substance | Inferred relationship | Existential restriction modifier |  | 
| Drug dependence during pregnancy, childbirth or the puerperium NOS | Causative agent | False | Psychoactive substance | Inferred relationship | Existential restriction modifier |  | 
| Amphetamine or other psychostimulant dependence | Causative agent | False | Psychoactive substance | Inferred relationship | Existential restriction modifier |  | 
| Other specified drug dependence | Causative agent | False | Psychoactive substance | Inferred relationship | Existential restriction modifier |  | 
| [X]Mental and behavioral disorders due to use of other stimulants, including caffeine: dependence syndrome | Causative agent | False | Psychoactive substance | Inferred relationship | Existential restriction modifier |  | 
| Cannabinoid | Is a | True | Psychoactive substance | Inferred relationship | Existential restriction modifier |  | 
| Nicotine | Is a | True | Psychoactive substance | Inferred relationship | Existential restriction modifier |  | 
| Trichloroethylene | Is a | True | Psychoactive substance | Inferred relationship | Existential restriction modifier |  | 
| [X]Mental and behavioral disorders due to use of crack cocaine: amnesic syndrome | Causative agent | False | Psychoactive substance | Inferred relationship | Existential restriction modifier |  | 
| [X]Mental and behavioral disorders due to use of crack cocaine: residual and late-onset psychotic disorder | Causative agent | False | Psychoactive substance | Inferred relationship | Existential restriction modifier |  | 
| [X]Mental and behavioral disorders due to use of cannabinoids: unspecified mental and behavioral disorder | Causative agent | False | Psychoactive substance | Inferred relationship | Existential restriction modifier |  | 
| [X]Mental and behavioral disorders due to use of cannabinoids: other mental and behavioral disorders | Causative agent | False | Psychoactive substance | Inferred relationship | Existential restriction modifier |  | 
| [X]Mental and behavioral disorders due to use of alcohol: other mental and behavioral disorders | Causative agent | False | Psychoactive substance | Inferred relationship | Existential restriction modifier |  | 
| [X]Mental and behavioral disorders due to use of opioids: withdrawal state | Causative agent | False | Psychoactive substance | Inferred relationship | Existential restriction modifier |  | 
| [X]Mental and behavioral disorders due to use of hallucinogens: psychotic disorder | Causative agent | False | Psychoactive substance | Inferred relationship | Existential restriction modifier |  | 
| [X]Mental and behavioral disorders due to use of cocaine: withdrawal state | Causative agent | False | Psychoactive substance | Inferred relationship | Existential restriction modifier |  | 
| [X]Mental and behavioral disorders due to use of hallucinogens: amnesic syndrome | Causative agent | False | Psychoactive substance | Inferred relationship | Existential restriction modifier |  | 
| [X]Mental and behavioral disorders due to use of tobacco: dependence syndrome | Causative agent | False | Psychoactive substance | Inferred relationship | Existential restriction modifier |  | 
| [X]Mental and behavioral disorders due to use of cocaine: withdrawal state with delirium | Causative agent | False | Psychoactive substance | Inferred relationship | Existential restriction modifier |  | 
| [X]Mental and behavioral disorder due to use of tobacco | Causative agent | False | Psychoactive substance | Inferred relationship | Existential restriction modifier |  | 
| [X]Mental and behavioral disorders due to use of cocaine: harmful use | Causative agent | False | Psychoactive substance | Inferred relationship | Existential restriction modifier |  | 
| [X]Mental and behavioral disorders due to use of tobacco: harmful use | Causative agent | False | Psychoactive substance | Inferred relationship | Existential restriction modifier |  | 
| [X]Mental and behavioral disorders due to use of volatile solvents: amnesic syndrome | Causative agent | False | Psychoactive substance | Inferred relationship | Existential restriction modifier |  | 
| [X]Mental and behavioral disorders due to use of cannabinoids: withdrawal state | Causative agent | False | Psychoactive substance | Inferred relationship | Existential restriction modifier |  | 
| [X]Mental and behavioral disorders due to use of volatile solvents: acute intoxication | Causative agent | False | Psychoactive substance | Inferred relationship | Existential restriction modifier |  | 
| [X]Mental and behavioral disorders due to use of volatile solvents: other mental and behavioral disorders | Causative agent | False | Psychoactive substance | Inferred relationship | Existential restriction modifier |  | 
| [X]Mental and behavioral disorders due to multiple drug use and use of other psychoactive substances: dependence syndrome | Causative agent | False | Psychoactive substance | Inferred relationship | Existential restriction modifier |  |