| Inbound Relationships | Type | Active | Source | Characteristic | Refinability | Group | 
| Nondependent antidepressant type drug abuse, continuous | Causative agent | False | Psychoactive substance of abuse - non-pharmaceutical | Inferred relationship | Existential restriction modifier |  | 
| Nondependent antidepressant type drug abuse, episodic | Causative agent | False | Psychoactive substance of abuse - non-pharmaceutical | Inferred relationship | Existential restriction modifier |  | 
| Nondependent antidepressant type drug abuse in remission | Causative agent | False | Psychoactive substance of abuse - non-pharmaceutical | Inferred relationship | Existential restriction modifier |  | 
| Nondependent mixed drug abuse | Causative agent | False | Psychoactive substance of abuse - non-pharmaceutical | Inferred relationship | Existential restriction modifier |  | 
| Nondependent mixed drug abuse, continuous | Causative agent | False | Psychoactive substance of abuse - non-pharmaceutical | Inferred relationship | Existential restriction modifier |  | 
| Nondependent mixed drug abuse, episodic | Causative agent | False | Psychoactive substance of abuse - non-pharmaceutical | Inferred relationship | Existential restriction modifier |  | 
| Nondependent mixed drug abuse in remission | Causative agent | False | Psychoactive substance of abuse - non-pharmaceutical | Inferred relationship | Existential restriction modifier |  | 
| Misuse of prescription only drugs | Causative agent | False | Psychoactive substance of abuse - non-pharmaceutical | Inferred relationship | Existential restriction modifier |  | 
| Drug dependence during pregnancy - baby delivered | Causative agent | False | Psychoactive substance of abuse - non-pharmaceutical | Inferred relationship | Existential restriction modifier |  | 
| Drug dependence in the puerperium - baby delivered | Causative agent | False | Psychoactive substance of abuse - non-pharmaceutical | Inferred relationship | Existential restriction modifier |  | 
| Drug dependence during pregnancy - baby not yet delivered | Causative agent | False | Psychoactive substance of abuse - non-pharmaceutical | Inferred relationship | Existential restriction modifier |  | 
| Drug dependence in the puerperium - baby delivered during previous episode of care | Causative agent | False | Psychoactive substance of abuse - non-pharmaceutical | Inferred relationship | Existential restriction modifier |  | 
| Hypnotic or anxiolytic abuse | Causative agent | False | Psychoactive substance of abuse - non-pharmaceutical | Inferred relationship | Existential restriction modifier |  | 
| Anxiolytic dependence | Causative agent | False | Psychoactive substance of abuse - non-pharmaceutical | Inferred relationship | Existential restriction modifier |  | 
| Diazepam dependence | Causative agent | False | Psychoactive substance of abuse - non-pharmaceutical | Inferred relationship | Existential restriction modifier |  | 
| Librium dependence | Causative agent | False | Psychoactive substance of abuse - non-pharmaceutical | Inferred relationship | Existential restriction modifier |  | 
| Methadone dependence | Causative agent | False | Psychoactive substance of abuse - non-pharmaceutical | Inferred relationship | Existential restriction modifier |  | 
| Morphine dependence | Causative agent | False | Psychoactive substance of abuse - non-pharmaceutical | Inferred relationship | Existential restriction modifier |  | 
| Pregnancy and drug dependence | Causative agent | False | Psychoactive substance of abuse - non-pharmaceutical | Inferred relationship | Existential restriction modifier |  | 
| Drug dependence during pregnancy, childbirth and the puerperium | Causative agent | False | Psychoactive substance of abuse - non-pharmaceutical | Inferred relationship | Existential restriction modifier |  | 
| Nondependent alcohol abuse | Causative agent | False | Psychoactive substance of abuse - non-pharmaceutical | Inferred relationship | Existential restriction modifier |  | 
| Nondependent hallucinogen abuse | Causative agent | False | Psychoactive substance of abuse - non-pharmaceutical | Inferred relationship | Existential restriction modifier |  | 
| Nondependent hypnotic or anxiolytic abuse | Causative agent | False | Psychoactive substance of abuse - non-pharmaceutical | Inferred relationship | Existential restriction modifier |  | 
| Cannabis/hallucinogen dependency | Causative agent | False | Psychoactive substance of abuse - non-pharmaceutical | Inferred relationship | Existential restriction modifier |  | 
| Other alcoholic psychosis | Causative agent | False | Psychoactive substance of abuse - non-pharmaceutical | Inferred relationship | Existential restriction modifier |  | 
| Other alcoholic psychosis NOS | Causative agent | False | Psychoactive substance of abuse - non-pharmaceutical | Inferred relationship | Existential restriction modifier |  | 
| Alcoholic psychosis NOS | Causative agent | False | Psychoactive substance of abuse - non-pharmaceutical | Inferred relationship | Existential restriction modifier |  | 
| Drug-induced paranoia or hallucinatory state NOS | Causative agent | False | Psychoactive substance of abuse - non-pharmaceutical | Inferred relationship | Existential restriction modifier |  | 
| Other drug psychoses | Causative agent | False | Psychoactive substance of abuse - non-pharmaceutical | Inferred relationship | Existential restriction modifier |  | 
| Other drug psychoses NOS | Causative agent | False | Psychoactive substance of abuse - non-pharmaceutical | Inferred relationship | Existential restriction modifier |  | 
| Drug psychosis NOS | Causative agent | False | Psychoactive substance of abuse - non-pharmaceutical | Inferred relationship | Existential restriction modifier |  | 
| Acute alcoholic intoxication, unspecified, in alcoholism | Causative agent | False | Psychoactive substance of abuse - non-pharmaceutical | Inferred relationship | Existential restriction modifier |  | 
| Acute alcoholic intoxication in alcoholism NOS | Causative agent | False | Psychoactive substance of abuse - non-pharmaceutical | Inferred relationship | Existential restriction modifier |  | 
| Unspecified chronic alcoholism | Causative agent | False | Psychoactive substance of abuse - non-pharmaceutical | Inferred relationship | Existential restriction modifier |  | 
| Chronic alcoholism NOS | Causative agent | False | Psychoactive substance of abuse - non-pharmaceutical | Inferred relationship | Existential restriction modifier |  | 
| Alcohol dependence syndrome NOS | Causative agent | False | Psychoactive substance of abuse - non-pharmaceutical | Inferred relationship | Existential restriction modifier |  | 
| Unspecified opioid dependence | Causative agent | False | Psychoactive substance of abuse - non-pharmaceutical | Inferred relationship | Existential restriction modifier |  | 
| Opioid drug dependence NOS | Causative agent | False | Psychoactive substance of abuse - non-pharmaceutical | Inferred relationship | Existential restriction modifier |  | 
| Hypnotic or anxiolytic dependence, unspecified | Causative agent | False | Psychoactive substance of abuse - non-pharmaceutical | Inferred relationship | Existential restriction modifier |  | 
| Hypnotic or anxiolytic dependence NOS | Causative agent | False | Psychoactive substance of abuse - non-pharmaceutical | Inferred relationship | Existential restriction modifier |  | 
| Cocaine dependence, unspecified | Causative agent | False | Psychoactive substance of abuse - non-pharmaceutical | Inferred relationship | Existential restriction modifier |  | 
| Cocaine drug dependence NOS | Causative agent | False | Psychoactive substance of abuse - non-pharmaceutical | Inferred relationship | Existential restriction modifier |  | 
| Amphetamine or psychostimulant dependence, unspecified | Causative agent | False | Psychoactive substance of abuse - non-pharmaceutical | Inferred relationship | Existential restriction modifier |  | 
| Amphetamine or psychostimulant dependence NOS | Causative agent | False | Psychoactive substance of abuse - non-pharmaceutical | Inferred relationship | Existential restriction modifier |  | 
| Hallucinogen dependence, unspecified | Causative agent | False | Psychoactive substance of abuse - non-pharmaceutical | Inferred relationship | Existential restriction modifier |  | 
| Hallucinogen dependence NOS | Causative agent | False | Psychoactive substance of abuse - non-pharmaceutical | Inferred relationship | Existential restriction modifier |  | 
| Other specified drug dependence, unspecified | Causative agent | False | Psychoactive substance of abuse - non-pharmaceutical | Inferred relationship | Existential restriction modifier |  | 
| Other specified drug dependence, continuous | Causative agent | False | Psychoactive substance of abuse - non-pharmaceutical | Inferred relationship | Existential restriction modifier |  | 
| Other specified drug dependence, episodic | Causative agent | False | Psychoactive substance of abuse - non-pharmaceutical | Inferred relationship | Existential restriction modifier |  | 
| Other specified drug dependence in remission | Causative agent | False | Psychoactive substance of abuse - non-pharmaceutical | Inferred relationship | Existential restriction modifier |  | 
| Other specified drug dependence NOS | Causative agent | False | Psychoactive substance of abuse - non-pharmaceutical | Inferred relationship | Existential restriction modifier |  | 
| Combined opioid with non-opioid drug dependence | Causative agent | False | Psychoactive substance of abuse - non-pharmaceutical | Inferred relationship | Existential restriction modifier |  | 
| Combined opioid with other drug dependence, unspecified | Causative agent | False | Psychoactive substance of abuse - non-pharmaceutical | Inferred relationship | Existential restriction modifier |  | 
| Combined opioid with non-opioid drug dependence, continuous | Causative agent | False | Psychoactive substance of abuse - non-pharmaceutical | Inferred relationship | Existential restriction modifier |  | 
| Combined opioid with non-opioid drug dependence, episodic | Causative agent | False | Psychoactive substance of abuse - non-pharmaceutical | Inferred relationship | Existential restriction modifier |  | 
| Combined opioid with non-opioid drug dependence in remission | Causative agent | False | Psychoactive substance of abuse - non-pharmaceutical | Inferred relationship | Existential restriction modifier |  | 
| Combined opioid with other drug dependence NOS | Causative agent | False | Psychoactive substance of abuse - non-pharmaceutical | Inferred relationship | Existential restriction modifier |  | 
| Combined drug dependence, excluding opioid, unspecified | Causative agent | False | Psychoactive substance of abuse - non-pharmaceutical | Inferred relationship | Existential restriction modifier |  | 
| Combined drug dependence, excluding opioid, NOS | Causative agent | False | Psychoactive substance of abuse - non-pharmaceutical | Inferred relationship | Existential restriction modifier |  | 
| Drug dependence NOS | Causative agent | False | Psychoactive substance of abuse - non-pharmaceutical | Inferred relationship | Existential restriction modifier |  | 
| Nondependent alcohol abuse, unspecified | Causative agent | False | Psychoactive substance of abuse - non-pharmaceutical | Inferred relationship | Existential restriction modifier |  | 
| Nondependent alcohol abuse NOS | Causative agent | False | Psychoactive substance of abuse - non-pharmaceutical | Inferred relationship | Existential restriction modifier |  | 
| Tobacco dependence, unspecified | Causative agent | False | Psychoactive substance of abuse - non-pharmaceutical | Inferred relationship | Existential restriction modifier |  | 
| Tobacco dependence NOS | Causative agent | False | Psychoactive substance of abuse - non-pharmaceutical | Inferred relationship | Existential restriction modifier |  | 
| Nondependent hallucinogen abuse, unspecified | Causative agent | False | Psychoactive substance of abuse - non-pharmaceutical | Inferred relationship | Existential restriction modifier |  | 
| Nondependent hallucinogen abuse NOS | Causative agent | False | Psychoactive substance of abuse - non-pharmaceutical | Inferred relationship | Existential restriction modifier |  | 
| Nondependent hypnotic or anxiolytic abuse, unspecified | Causative agent | False | Psychoactive substance of abuse - non-pharmaceutical | Inferred relationship | Existential restriction modifier |  | 
| Nondependent hypnotic or anxiolytic abuse NOS | Causative agent | False | Psychoactive substance of abuse - non-pharmaceutical | Inferred relationship | Existential restriction modifier |  | 
| Nondependent opioid abuse, unspecified | Causative agent | False | Psychoactive substance of abuse - non-pharmaceutical | Inferred relationship | Existential restriction modifier |  | 
| Nondependent opioid abuse NOS | Causative agent | False | Psychoactive substance of abuse - non-pharmaceutical | Inferred relationship | Existential restriction modifier |  | 
| Nondependent amphetamine or psychostimulant abuse, unspecified | Causative agent | False | Psychoactive substance of abuse - non-pharmaceutical | Inferred relationship | Existential restriction modifier |  | 
| Nondependent amphetamine or psychostimulant abuse NOS | Causative agent | False | Psychoactive substance of abuse - non-pharmaceutical | Inferred relationship | Existential restriction modifier |  | 
| Nondependent antidepressant type drug abuse, unspecified | Causative agent | False | Psychoactive substance of abuse - non-pharmaceutical | Inferred relationship | Existential restriction modifier |  | 
| Nondependent antidepressant type drug abuse NOS | Causative agent | False | Psychoactive substance of abuse - non-pharmaceutical | Inferred relationship | Existential restriction modifier |  | 
| Nondependent mixed drug abuse, unspecified | Causative agent | False | Psychoactive substance of abuse - non-pharmaceutical | Inferred relationship | Existential restriction modifier |  | 
| Nondependent mixed drug abuse NOS | Causative agent | False | Psychoactive substance of abuse - non-pharmaceutical | Inferred relationship | Existential restriction modifier |  | 
| Nondependent other drug abuse, unspecified | Causative agent | False | Psychoactive substance of abuse - non-pharmaceutical | Inferred relationship | Existential restriction modifier |  | 
| Nondependent other drug abuse, continuous | Causative agent | False | Psychoactive substance of abuse - non-pharmaceutical | Inferred relationship | Existential restriction modifier |  | 
| Nondependent other drug abuse, episodic | Causative agent | False | Psychoactive substance of abuse - non-pharmaceutical | Inferred relationship | Existential restriction modifier |  | 
| Nondependent other drug abuse in remission | Causative agent | False | Psychoactive substance of abuse - non-pharmaceutical | Inferred relationship | Existential restriction modifier |  | 
| Nondependent other drug abuse NOS | Causative agent | False | Psychoactive substance of abuse - non-pharmaceutical | Inferred relationship | Existential restriction modifier |  | 
| Misuse of drugs NOS | Causative agent | False | Psychoactive substance of abuse - non-pharmaceutical | Inferred relationship | Existential restriction modifier |  | 
| [X]Mental and behavioral disorders due to psychoactive substance use | Causative agent | False | Psychoactive substance of abuse - non-pharmaceutical | Inferred relationship | Existential restriction modifier |  | 
| [X]Mental and behavioral disorders due to use of alcohol | Causative agent | False | Psychoactive substance of abuse - non-pharmaceutical | Inferred relationship | Existential restriction modifier |  | 
| [X]Mental and behavioral disorders due to use of alcohol: acute intoxication | Causative agent | False | Psychoactive substance of abuse - non-pharmaceutical | Inferred relationship | Existential restriction modifier |  | 
| [X]Mental and behavioral disorders due to use of alcohol: harmful use | Causative agent | False | Psychoactive substance of abuse - non-pharmaceutical | Inferred relationship | Existential restriction modifier |  | 
| [X]Mental and behavioral disorders due to use of alcohol: withdrawal state | Causative agent | False | Psychoactive substance of abuse - non-pharmaceutical | Inferred relationship | Existential restriction modifier |  | 
| [X]Mental and behavioral disorders due to use of alcohol: withdrawal state with delirium | Causative agent | False | Psychoactive substance of abuse - non-pharmaceutical | Inferred relationship | Existential restriction modifier |  | 
| [X]Mental and behavioral disorders due to use of alcohol: amnesic syndrome | Causative agent | False | Psychoactive substance of abuse - non-pharmaceutical | Inferred relationship | Existential restriction modifier |  | 
| [X]Mental and behavioral disorders due to use of alcohol: other mental and behavioral disorders | Causative agent | False | Psychoactive substance of abuse - non-pharmaceutical | Inferred relationship | Existential restriction modifier |  | 
| [X]Mental and behavioral disorders due to use of alcohol: unspecified mental and behavioral disorder | Causative agent | False | Psychoactive substance of abuse - non-pharmaceutical | Inferred relationship | Existential restriction modifier |  | 
| [X]Mental and behavioral disorders due to use of opioids | Causative agent | False | Psychoactive substance of abuse - non-pharmaceutical | Inferred relationship | Existential restriction modifier |  | 
| [X]Mental and behavioral disorders due to use of opioids: acute intoxication | Causative agent | False | Psychoactive substance of abuse - non-pharmaceutical | Inferred relationship | Existential restriction modifier |  | 
| [X]Mental and behavioral disorders due to use of opioids: harmful use | Causative agent | False | Psychoactive substance of abuse - non-pharmaceutical | Inferred relationship | Existential restriction modifier |  | 
| [X]Mental and behavioral disorders due to use of opioids: withdrawal state with delirium | Causative agent | False | Psychoactive substance of abuse - non-pharmaceutical | Inferred relationship | Existential restriction modifier |  | 
| [X]Mental and behavioral disorders due to use of opioids: psychotic disorder | Causative agent | False | Psychoactive substance of abuse - non-pharmaceutical | Inferred relationship | Existential restriction modifier |  | 
| [X]Mental and behavioral disorders due to use of opioids: amnesic syndrome | Causative agent | False | Psychoactive substance of abuse - non-pharmaceutical | Inferred relationship | Existential restriction modifier |  | 
| [X]Mental and behavioral disorders due to use of opioids: residual and late-onset psychotic disorder | Causative agent | False | Psychoactive substance of abuse - non-pharmaceutical | Inferred relationship | Existential restriction modifier |  | 
| [X]Mental and behavioral disorders due to use of opioids: other mental and behavioral disorders | Causative agent | False | Psychoactive substance of abuse - non-pharmaceutical | Inferred relationship | Existential restriction modifier |  | 
| [X]Mental and behavioral disorders due to use of opioids: unspecified mental and behavioral disorder | Causative agent | False | Psychoactive substance of abuse - non-pharmaceutical | Inferred relationship | Existential restriction modifier |  | 
| [X]Mental and behavioral disorders due to use of cannabinoids | Causative agent | False | Psychoactive substance of abuse - non-pharmaceutical | Inferred relationship | Existential restriction modifier |  |