| Inbound Relationships | Type | Active | Source | Characteristic | Refinability | Group | 
| Nicotine dependence | Causative agent | False | Psychoactive substance of abuse - non-pharmaceutical | Inferred relationship | Existential restriction modifier |  | 
| Sedative, hypnotic AND/OR anxiolytic-induced sleep disorder | Causative agent | False | Psychoactive substance of abuse - non-pharmaceutical | Inferred relationship | Existential restriction modifier |  | 
| Phencyclidine dependence | Causative agent | False | Psychoactive substance of abuse - non-pharmaceutical | Inferred relationship | Existential restriction modifier |  | 
| Steroid abuse | Causative agent | False | Psychoactive substance of abuse - non-pharmaceutical | Inferred relationship | Existential restriction modifier |  | 
| Alcohol-induced psychotic disorder with delusions | Causative agent | False | Psychoactive substance of abuse - non-pharmaceutical | Inferred relationship | Existential restriction modifier |  | 
| Drug withdrawal syndrome in newborn | Causative agent | False | Psychoactive substance of abuse - non-pharmaceutical | Inferred relationship | Existential restriction modifier |  | 
| Cocaine-induced psychotic disorder with hallucinations | Causative agent | False | Psychoactive substance of abuse - non-pharmaceutical | Inferred relationship | Existential restriction modifier |  | 
| Cannabis delusional disorder | Causative agent | False | Psychoactive substance of abuse - non-pharmaceutical | Inferred relationship | Existential restriction modifier |  | 
| Sedative abuse | Causative agent | False | Psychoactive substance of abuse - non-pharmaceutical | Inferred relationship | Existential restriction modifier |  | 
| Dependent drug abuse | Causative agent | False | Psychoactive substance of abuse - non-pharmaceutical | Inferred relationship | Existential restriction modifier |  | 
| Substance abuse | Causative agent | False | Psychoactive substance of abuse - non-pharmaceutical | Inferred relationship | Existential restriction modifier |  | 
| Alcohol dependence | Causative agent | False | Psychoactive substance of abuse - non-pharmaceutical | Inferred relationship | Existential restriction modifier |  | 
| Cocaine intoxication delirium | Causative agent | False | Psychoactive substance of abuse - non-pharmaceutical | Inferred relationship | Existential restriction modifier |  | 
| Inhalant abuse | Causative agent | False | Psychoactive substance of abuse - non-pharmaceutical | Inferred relationship | Existential restriction modifier |  | 
| Alcohol hallucinosis | Causative agent | False | Psychoactive substance of abuse - non-pharmaceutical | Inferred relationship | Existential restriction modifier |  | 
| Caffeine-induced anxiety disorder | Causative agent | False | Psychoactive substance of abuse - non-pharmaceutical | Inferred relationship | Existential restriction modifier |  | 
| Phencyclidine abuse | Causative agent | False | Psychoactive substance of abuse - non-pharmaceutical | Inferred relationship | Existential restriction modifier |  | 
| Sexual dysfunction caused by amfetamine | Causative agent | False | Psychoactive substance of abuse - non-pharmaceutical | Inferred relationship | Existential restriction modifier |  | 
| Sexual dysfunction caused by opioid | Causative agent | False | Psychoactive substance of abuse - non-pharmaceutical | Inferred relationship | Existential restriction modifier |  | 
| Alcohol amnestic disorder | Causative agent | False | Psychoactive substance of abuse - non-pharmaceutical | Inferred relationship | Existential restriction modifier |  | 
| Hallucinogen abuse | Causative agent | False | Psychoactive substance of abuse - non-pharmaceutical | Inferred relationship | Existential restriction modifier |  | 
| Psychoactive substance withdrawal syndrome | Causative agent | False | Psychoactive substance of abuse - non-pharmaceutical | Inferred relationship | Existential restriction modifier |  | 
| Inhalant-induced psychotic disorder with delusions | Causative agent | False | Psychoactive substance of abuse - non-pharmaceutical | Inferred relationship | Existential restriction modifier |  | 
| Opioid dependence | Causative agent | False | Psychoactive substance of abuse - non-pharmaceutical | Inferred relationship | Existential restriction modifier |  | 
| Organic mental disorder caused by cannabis | Causative agent | False | Psychoactive substance of abuse - non-pharmaceutical | Inferred relationship | Existential restriction modifier |  | 
| Opioid intoxication | Causative agent | False | Psychoactive substance of abuse - non-pharmaceutical | Inferred relationship | Existential restriction modifier |  | 
| Cocaine abuse | Causative agent | False | Psychoactive substance of abuse - non-pharmaceutical | Inferred relationship | Existential restriction modifier |  | 
| Amphetamine withdrawal syndrome | Causative agent | False | Psychoactive substance of abuse - non-pharmaceutical | Inferred relationship | Existential restriction modifier |  | 
| Alcohol paranoia | Causative agent | False | Psychoactive substance of abuse - non-pharmaceutical | Inferred relationship | Existential restriction modifier |  | 
| Cocaine withdrawal syndrome | Causative agent | False | Psychoactive substance of abuse - non-pharmaceutical | Inferred relationship | Existential restriction modifier |  | 
| Anxiety disorder caused by amfetamine | Causative agent | False | Psychoactive substance of abuse - non-pharmaceutical | Inferred relationship | Existential restriction modifier |  | 
| Psychoactive substance-induced organic amnestic disorder | Causative agent | False | Psychoactive substance of abuse - non-pharmaceutical | Inferred relationship | Existential restriction modifier |  | 
| Organic mental disorder caused by amphetamine and/or amfetamine derivative | Causative agent | False | Psychoactive substance of abuse - non-pharmaceutical | Inferred relationship | Existential restriction modifier |  | 
| Steroid withdrawal syndrome | Causative agent | False | Psychoactive substance of abuse - non-pharmaceutical | Inferred relationship | Existential restriction modifier |  | 
| Amphetamine abuse | Causative agent | False | Psychoactive substance of abuse - non-pharmaceutical | Inferred relationship | Existential restriction modifier |  | 
| Caffeine intoxication | Causative agent | False | Psychoactive substance of abuse - non-pharmaceutical | Inferred relationship | Existential restriction modifier |  | 
| Cannabis dependence | Causative agent | False | Psychoactive substance of abuse - non-pharmaceutical | Inferred relationship | Existential restriction modifier |  | 
| Alcohol withdrawal syndrome without complication | Causative agent | False | Psychoactive substance of abuse - non-pharmaceutical | Inferred relationship | Existential restriction modifier |  | 
| Alcohol withdrawal delirium | Causative agent | False | Psychoactive substance of abuse - non-pharmaceutical | Inferred relationship | Existential restriction modifier |  | 
| Opioid withdrawal syndrome | Causative agent | False | Psychoactive substance of abuse - non-pharmaceutical | Inferred relationship | Existential restriction modifier |  | 
| Delirium caused by amphetamine | Causative agent | False | Psychoactive substance of abuse - non-pharmaceutical | Inferred relationship | Existential restriction modifier |  | 
| Opioid-induced sleep disorder | Causative agent | False | Psychoactive substance of abuse - non-pharmaceutical | Inferred relationship | Existential restriction modifier |  | 
| Inhalant-induced mood disorder | Causative agent | False | Psychoactive substance of abuse - non-pharmaceutical | Inferred relationship | Existential restriction modifier |  | 
| Tobacco dependence syndrome | Causative agent | False | Psychoactive substance of abuse - non-pharmaceutical | Inferred relationship | Existential restriction modifier |  | 
| Nicotine withdrawal syndrome | Causative agent | False | Psychoactive substance of abuse - non-pharmaceutical | Inferred relationship | Existential restriction modifier |  | 
| Psychoactive substance abuse | Causative agent | False | Psychoactive substance of abuse - non-pharmaceutical | Inferred relationship | Existential restriction modifier |  | 
| Caffeine withdrawal syndrome | Causative agent | False | Psychoactive substance of abuse - non-pharmaceutical | Inferred relationship | Existential restriction modifier |  | 
| Ergotamine withdrawal syndrome | Causative agent | False | Psychoactive substance of abuse - non-pharmaceutical | Inferred relationship | Existential restriction modifier |  | 
| Drug habituation | Causative agent | False | Psychoactive substance of abuse - non-pharmaceutical | Inferred relationship | Existential restriction modifier |  | 
| Pathological alcohol intoxication | Causative agent | False | Psychoactive substance of abuse - non-pharmaceutical | Inferred relationship | Existential restriction modifier |  | 
| Alcoholic paranoia | Causative agent | False | Psychoactive substance of abuse - non-pharmaceutical | Inferred relationship | Existential restriction modifier |  | 
| Drug-induced paranoia or hallucinatory states | Causative agent | False | Psychoactive substance of abuse - non-pharmaceutical | Inferred relationship | Existential restriction modifier |  | 
| Paranoid state caused by drug | Causative agent | False | Psychoactive substance of abuse - non-pharmaceutical | Inferred relationship | Existential restriction modifier |  | 
| Hallucinosis caused by drug | Causative agent | False | Psychoactive substance of abuse - non-pharmaceutical | Inferred relationship | Existential restriction modifier |  | 
| Delirium caused by drug | Causative agent | False | Psychoactive substance of abuse - non-pharmaceutical | Inferred relationship | Existential restriction modifier |  | 
| Dementia caused by drug | Causative agent | False | Psychoactive substance of abuse - non-pharmaceutical | Inferred relationship | Existential restriction modifier |  | 
| Amnestic disorder caused by drug | Causative agent | False | Psychoactive substance of abuse - non-pharmaceutical | Inferred relationship | Existential restriction modifier |  | 
| Depressive disorder caused by drug | Causative agent | False | Psychoactive substance of abuse - non-pharmaceutical | Inferred relationship | Existential restriction modifier |  | 
| Personality disorder caused by drug | Causative agent | False | Psychoactive substance of abuse - non-pharmaceutical | Inferred relationship | Existential restriction modifier |  | 
| Acute alcoholic intoxication in alcoholism | Causative agent | False | Psychoactive substance of abuse - non-pharmaceutical | Inferred relationship | Existential restriction modifier |  | 
| Continuous acute alcoholic intoxication in alcoholism | Causative agent | False | Psychoactive substance of abuse - non-pharmaceutical | Inferred relationship | Existential restriction modifier |  | 
| Episodic acute alcoholic intoxication in alcoholism | Causative agent | False | Psychoactive substance of abuse - non-pharmaceutical | Inferred relationship | Existential restriction modifier |  | 
| Acute alcoholic intoxication in remission, in alcoholism | Causative agent | False | Psychoactive substance of abuse - non-pharmaceutical | Inferred relationship | Existential restriction modifier |  | 
| Continuous chronic alcoholism | Causative agent | False | Psychoactive substance of abuse - non-pharmaceutical | Inferred relationship | Existential restriction modifier |  | 
| Episodic chronic alcoholism | Causative agent | False | Psychoactive substance of abuse - non-pharmaceutical | Inferred relationship | Existential restriction modifier |  | 
| Chronic alcoholism in remission | Causative agent | False | Psychoactive substance of abuse - non-pharmaceutical | Inferred relationship | Existential restriction modifier |  | 
| Drug dependence | Causative agent | False | Psychoactive substance of abuse - non-pharmaceutical | Inferred relationship | Existential restriction modifier |  | 
| Continuous opioid dependence | Causative agent | False | Psychoactive substance of abuse - non-pharmaceutical | Inferred relationship | Existential restriction modifier |  | 
| Episodic opioid dependence | Causative agent | False | Psychoactive substance of abuse - non-pharmaceutical | Inferred relationship | Existential restriction modifier |  | 
| Opioid dependence in remission | Causative agent | False | Psychoactive substance of abuse - non-pharmaceutical | Inferred relationship | Existential restriction modifier |  | 
| Hypnotic or anxiolytic dependence, continuous | Causative agent | False | Psychoactive substance of abuse - non-pharmaceutical | Inferred relationship | Existential restriction modifier |  | 
| Hypnotic or anxiolytic dependence, episodic | Causative agent | False | Psychoactive substance of abuse - non-pharmaceutical | Inferred relationship | Existential restriction modifier |  | 
| Hypnotic or anxiolytic dependence in remission | Causative agent | False | Psychoactive substance of abuse - non-pharmaceutical | Inferred relationship | Existential restriction modifier |  | 
| Cocaine type drug dependence | Causative agent | False | Psychoactive substance of abuse - non-pharmaceutical | Inferred relationship | Existential restriction modifier |  | 
| Cocaine dependence, continuous | Causative agent | False | Psychoactive substance of abuse - non-pharmaceutical | Inferred relationship | Existential restriction modifier |  | 
| Cocaine dependence, episodic | Causative agent | False | Psychoactive substance of abuse - non-pharmaceutical | Inferred relationship | Existential restriction modifier |  | 
| Cocaine dependence in remission | Causative agent | False | Psychoactive substance of abuse - non-pharmaceutical | Inferred relationship | Existential restriction modifier |  | 
| Hallucinogen dependence, continuous | Causative agent | False | Psychoactive substance of abuse - non-pharmaceutical | Inferred relationship | Existential restriction modifier |  | 
| Hallucinogen dependence, episodic | Causative agent | False | Psychoactive substance of abuse - non-pharmaceutical | Inferred relationship | Existential restriction modifier |  | 
| Hallucinogen dependence in remission | Causative agent | False | Psychoactive substance of abuse - non-pharmaceutical | Inferred relationship | Existential restriction modifier |  | 
| Combined drug dependence, excluding opioids | Causative agent | False | Psychoactive substance of abuse - non-pharmaceutical | Inferred relationship | Existential restriction modifier |  | 
| Combined drug dependence, excluding opioid, continuous | Causative agent | False | Psychoactive substance of abuse - non-pharmaceutical | Inferred relationship | Existential restriction modifier |  | 
| Combined drug dependence, excluding opioid, episodic | Causative agent | False | Psychoactive substance of abuse - non-pharmaceutical | Inferred relationship | Existential restriction modifier |  | 
| Combined drug dependence, excluding opioid, in remission | Causative agent | False | Psychoactive substance of abuse - non-pharmaceutical | Inferred relationship | Existential restriction modifier |  | 
| Nondependent alcohol abuse, continuous | Causative agent | False | Psychoactive substance of abuse - non-pharmaceutical | Inferred relationship | Existential restriction modifier |  | 
| Nondependent alcohol abuse, episodic | Causative agent | False | Psychoactive substance of abuse - non-pharmaceutical | Inferred relationship | Existential restriction modifier |  | 
| Nondependent alcohol abuse in remission | Causative agent | False | Psychoactive substance of abuse - non-pharmaceutical | Inferred relationship | Existential restriction modifier |  | 
| Tobacco dependence, continuous | Causative agent | False | Psychoactive substance of abuse - non-pharmaceutical | Inferred relationship | Existential restriction modifier |  | 
| Tobacco dependence, episodic | Causative agent | False | Psychoactive substance of abuse - non-pharmaceutical | Inferred relationship | Existential restriction modifier |  | 
| Tobacco dependence in remission | Causative agent | False | Psychoactive substance of abuse - non-pharmaceutical | Inferred relationship | Existential restriction modifier |  | 
| Nondependent hallucinogen abuse, continuous | Causative agent | False | Psychoactive substance of abuse - non-pharmaceutical | Inferred relationship | Existential restriction modifier |  | 
| Nondependent hallucinogen abuse, episodic | Causative agent | False | Psychoactive substance of abuse - non-pharmaceutical | Inferred relationship | Existential restriction modifier |  | 
| Nondependent hallucinogen abuse in remission | Causative agent | False | Psychoactive substance of abuse - non-pharmaceutical | Inferred relationship | Existential restriction modifier |  | 
| Nondependent hypnotic or anxiolytic abuse, continuous | Causative agent | False | Psychoactive substance of abuse - non-pharmaceutical | Inferred relationship | Existential restriction modifier |  | 
| Nondependent hypnotic or anxiolytic abuse, episodic | Causative agent | False | Psychoactive substance of abuse - non-pharmaceutical | Inferred relationship | Existential restriction modifier |  | 
| Nondependent hypnotic or anxiolytic abuse in remission | Causative agent | False | Psychoactive substance of abuse - non-pharmaceutical | Inferred relationship | Existential restriction modifier |  | 
| Nondependent opioid abuse | Causative agent | False | Psychoactive substance of abuse - non-pharmaceutical | Inferred relationship | Existential restriction modifier |  | 
| Nondependent opioid abuse, continuous | Causative agent | False | Psychoactive substance of abuse - non-pharmaceutical | Inferred relationship | Existential restriction modifier |  | 
| Nondependent opioid abuse, episodic | Causative agent | False | Psychoactive substance of abuse - non-pharmaceutical | Inferred relationship | Existential restriction modifier |  | 
| Nondependent opioid abuse in remission | Causative agent | False | Psychoactive substance of abuse - non-pharmaceutical | Inferred relationship | Existential restriction modifier |  | 
| Nondependent antidepressant type drug abuse, continuous | Causative agent | False | Psychoactive substance of abuse - non-pharmaceutical | Inferred relationship | Existential restriction modifier |  |