| Inbound Relationships | Type | Active | Source | Characteristic | Refinability | Group | 
| Optic nerve hypoplasia due to endocrine deficiency | Finding site | True | Optic nerve structure | Inferred relationship | Existential restriction modifier | 1 | 
| Optic atrophy due to late congenital syphilis | Finding site | True | Optic nerve structure | Inferred relationship | Existential restriction modifier | 1 | 
| Chronic relapsing inflammatory optic neuropathy | Finding site | True | Optic nerve structure | Inferred relationship | Existential restriction modifier | 1 | 
| Ocular anomalies, axonal neuropathy, developmental delay syndrome | Finding site | True | Optic nerve structure | Inferred relationship | Existential restriction modifier | 1 | 
| Early-onset progressive diffuse brain atrophy, microcephaly, muscle weakness, optic atrophy syndrome | Finding site | True | Optic nerve structure | Inferred relationship | Existential restriction modifier | 2 | 
| X-linked keloid scarring, reduced joint mobility, increased optic cup-to-disc ratio syndrome | Finding site | True | Optic nerve structure | Inferred relationship | Existential restriction modifier | 5 | 
| Disorder of optic nerve due to micronutrient deficiency | Finding site | True | Optic nerve structure | Inferred relationship | Existential restriction modifier | 1 | 
| Disorder of optic nerve due to thiamine deficiency | Finding site | True | Optic nerve structure | Inferred relationship | Existential restriction modifier | 1 | 
| Autosomal recessive spastic paraplegia type 74 | Finding site | True | Optic nerve structure | Inferred relationship | Existential restriction modifier | 2 | 
| X-linked spastic paraplegia type 2 | Finding site | True | Optic nerve structure | Inferred relationship | Existential restriction modifier | 2 | 
| Autosomal recessive spastic paraplegia type 55 | Finding site | True | Optic nerve structure | Inferred relationship | Existential restriction modifier | 2 | 
| Autosomal recessive spastic paraplegia type 57 | Finding site | True | Optic nerve structure | Inferred relationship | Existential restriction modifier | 2 | 
| Spastic paraplegia, optic atrophy, neuropathy syndrome | Finding site | True | Optic nerve structure | Inferred relationship | Existential restriction modifier | 2 | 
| Multiple mitochondrial dysfunctions syndrome type 4 | Finding site | True | Optic nerve structure | Inferred relationship | Existential restriction modifier | 5 | 
| Posterior ischemic optic neuropathy due to arteritis | Finding site | True | Optic nerve structure | Inferred relationship | Existential restriction modifier | 1 | 
| Phospholipase A2 activating protein-associated neurodevelopmental disorder | Finding site | True | Optic nerve structure | Inferred relationship | Existential restriction modifier | 3 | 
| Auditory neuropathy, optic atrophy syndrome | Finding site | True | Optic nerve structure | Inferred relationship | Existential restriction modifier | 1 | 
| Optic atrophy, ataxia, peripheral neuropathy, global developmental delay syndrome | Finding site | True | Optic nerve structure | Inferred relationship | Existential restriction modifier | 1 | 
| Primary malignant ependymoma of optic nerve | Finding site | True | Optic nerve structure | Inferred relationship | Existential restriction modifier | 1 | 
| Primary malignant ependymoma of optic nerve | Finding site | False | Optic nerve structure | Inferred relationship | Existential restriction modifier | 2 | 
| Idiopathic optic neuritis | Finding site | True | Optic nerve structure | Inferred relationship | Existential restriction modifier | 1 | 
| Non-arteritic posterior ischemic optic neuropathy | Finding site | True | Optic nerve structure | Inferred relationship | Existential restriction modifier | 1 | 
| Optic neuritis due to demyelinating disease of central nervous system | Finding site | True | Optic nerve structure | Inferred relationship | Existential restriction modifier | 1 | 
| Disorder of optic nerve following administration of vaccine to produce active immunity | Finding site | True | Optic nerve structure | Inferred relationship | Existential restriction modifier | 2 | 
| X-linked optic atrophy | Finding site | True | Optic nerve structure | Inferred relationship | Existential restriction modifier | 1 | 
| Mitochondrial enoyl coenzyme A reductase protein-associated neurodegeneration syndrome | Finding site | True | Optic nerve structure | Inferred relationship | Existential restriction modifier | 1 | 
| Short stature, optic nerve atrophy, Pelger-Huët anomaly syndrome | Finding site | True | Optic nerve structure | Inferred relationship | Existential restriction modifier | 1 | 
| Primary malignant astrocytoma of optic nerve | Finding site | True | Optic nerve structure | Inferred relationship | Existential restriction modifier | 1 | 
| Infantile-onset axonal motor and sensory neuropathy, optic atrophy, neurodegenerative syndrome | Finding site | True | Optic nerve structure | Inferred relationship | Existential restriction modifier | 1 | 
| Optic neuritis NOS | Finding site | False | Optic nerve structure | Inferred relationship | Existential restriction modifier | 1 | 
| Unspecified optic neuritis | Finding site | False | Optic nerve structure | Inferred relationship | Existential restriction modifier | 1 | 
| Unspecified optic atrophy | Finding site | False | Optic nerve structure | Inferred relationship | Existential restriction modifier | 1 | 
| Optic atrophy NOS | Finding site | False | Optic nerve structure | Inferred relationship | Existential restriction modifier | 1 | 
| Hereditary optic atrophy NOS | Finding site | False | Optic nerve structure | Inferred relationship | Existential restriction modifier | 1 |