| Inbound Relationships | Type | Active | Source | Characteristic | Refinability | Group | 
| Intraocular optic nerve glioma | Finding site | False | Optic nerve structure | Inferred relationship | Existential restriction modifier | 1 | 
| Neoplasm of uncertain behavior of optic nerve | Finding site | True | Optic nerve structure | Inferred relationship | Existential restriction modifier | 1 | 
| Primary optic atrophy | Finding site | True | Optic nerve structure | Inferred relationship | Existential restriction modifier | 1 | 
| Paraneoplastic optic neuropathy | Finding site | True | Optic nerve structure | Inferred relationship | Existential restriction modifier | 1 | 
| Excision of lesion of optic nerve (II) | Procedure site - Direct | True | Optic nerve structure | Inferred relationship | Existential restriction modifier | 2 | 
| Repair of optic nerve (II) | Procedure site - Direct | True | Optic nerve structure | Inferred relationship | Existential restriction modifier | 1 | 
| Compressive optic atrophy | Finding site | True | Optic nerve structure | Inferred relationship | Existential restriction modifier | 1 | 
| Primary malignant neoplasm of optic nerve | Finding site | True | Optic nerve structure | Inferred relationship | Existential restriction modifier | 1 | 
| Dominant hereditary optic atrophy | Finding site | True | Optic nerve structure | Inferred relationship | Existential restriction modifier | 1 | 
| Optic atrophy associated with retinal dystrophy | Finding site | True | Optic nerve structure | Inferred relationship | Existential restriction modifier | 1 | 
| Injection of optic nerve | Procedure site - Indirect | True | Optic nerve structure | Inferred relationship | Existential restriction modifier | 1 | 
| Secondary optic atrophy | Finding site | True | Optic nerve structure | Inferred relationship | Existential restriction modifier | 1 | 
| Optic atrophy secondary to retinal disease | Finding site | True | Optic nerve structure | Inferred relationship | Existential restriction modifier | 1 | 
| Foster-Kennedy syndrome | Finding site | True | Optic nerve structure | Inferred relationship | Existential restriction modifier | 1 | 
| Hereditary optic atrophy | Finding site | True | Optic nerve structure | Inferred relationship | Existential restriction modifier | 1 | 
| Optic atrophy | Finding site | True | Optic nerve structure | Inferred relationship | Existential restriction modifier | 1 | 
| Exploration of optic nerve (II) | Procedure site - Direct | True | Optic nerve structure | Inferred relationship | Existential restriction modifier | 1 | 
| Radial optic neurotomy | Procedure site - Direct | True | Optic nerve structure | Inferred relationship | Existential restriction modifier | 1 | 
| Optic nerve glioma | Finding site | True | Optic nerve structure | Inferred relationship | Existential restriction modifier | 1 | 
| Benign neoplasm of optic nerve | Finding site | True | Optic nerve structure | Inferred relationship | Existential restriction modifier | 1 | 
| Optic neuritis | Finding site | True | Optic nerve structure | Inferred relationship | Existential restriction modifier | 1 | 
| Malignant optic glioma | Finding site | False | Optic nerve structure | Inferred relationship | Existential restriction modifier | 1 | 
| Compressive optic neuropathy due to thyroid eye disease | Finding site | True | Optic nerve structure | Inferred relationship | Existential restriction modifier | 1 | 
| Hereditary optic atrophy NOS | Finding site | False | Optic nerve structure | Inferred relationship | Existential restriction modifier | 1 | 
| Radiation damage to optic nerve | Finding site | True | Optic nerve structure | Inferred relationship | Existential restriction modifier | 1 | 
| Intracranial transection of optic nerve (II) | Procedure site - Direct | True | Optic nerve structure | Inferred relationship | Existential restriction modifier | 1 | 
| Incipient prechiasmal optic nerve compression syndrome | Finding site | True | Optic nerve structure | Inferred relationship | Existential restriction modifier | 1 | 
| Intracranial stereotactic neurolysis of optic nerve (II) | Procedure site - Direct | True | Optic nerve structure | Inferred relationship | Existential restriction modifier | 1 | 
| Diabetes mellitus AND insipidus with optic atrophy AND deafness | Finding site | False | Optic nerve structure | Inferred relationship | Existential restriction modifier | 1 | 
| Endoscopy of nasal sinus with decompression of optic nerve | Procedure site - Direct | False | Optic nerve structure | Inferred relationship | Existential restriction modifier | 2 | 
| Endoscopy of nasal sinus with decompression of optic nerve | Procedure site - Direct | True | Optic nerve structure | Inferred relationship | Existential restriction modifier | 2 | 
| Endoscopic decompression of optic nerve | Procedure site - Direct | False | Optic nerve structure | Inferred relationship | Existential restriction modifier | 1 | 
| Endoscopic decompression of optic nerve | Procedure site - Direct | True | Optic nerve structure | Inferred relationship | Existential restriction modifier | 1 | 
| Septo-optic dysplasia sequence | Finding site | False | Optic nerve structure | Inferred relationship | Existential restriction modifier | 5 | 
| Hypoplasia of the optic nerve | Finding site | False | Optic nerve structure | Inferred relationship | Existential restriction modifier | 3 | 
| Partial hypoplasia of optic disc | Finding site | False | Optic nerve structure | Inferred relationship | Existential restriction modifier | 3 | 
| Congenital anomaly of optic nerve | Finding site | False | Optic nerve structure | Inferred relationship | Existential restriction modifier | 2 | 
| Malignant optic glioma | Finding site | False | Optic nerve structure | Inferred relationship | Existential restriction modifier | 2 | 
| Malignant optic glioma of adulthood | Finding site | False | Optic nerve structure | Inferred relationship | Existential restriction modifier | 3 | 
| Autosomal dominant optic atrophy plus syndrome | Finding site | True | Optic nerve structure | Inferred relationship | Existential restriction modifier | 1 | 
| Oculocerebral dysplasia syndrome | Finding site | False | Optic nerve structure | Inferred relationship | Existential restriction modifier | 3 | 
| Autosomal dominant optic atrophy classic form | Finding site | True | Optic nerve structure | Inferred relationship | Existential restriction modifier | 1 | 
| Autosomal dominant optic atrophy and peripheral neuropathy syndrome | Finding site | True | Optic nerve structure | Inferred relationship | Existential restriction modifier | 2 | 
| Behr syndrome | Finding site | False | Optic nerve structure | Inferred relationship | Existential restriction modifier | 1 | 
| Leber plus disease | Finding site | True | Optic nerve structure | Inferred relationship | Existential restriction modifier | 2 | 
| Autosomal dominant optic atrophy and cataract | Finding site | True | Optic nerve structure | Inferred relationship | Existential restriction modifier | 2 | 
| Optic neuropathy due to folate deficiency | Finding site | True | Optic nerve structure | Inferred relationship | Existential restriction modifier | 1 | 
| Cerebellar ataxia, areflexia, pes cavus, optic atrophy, sensorineural hearing loss syndrome | Finding site | True | Optic nerve structure | Inferred relationship | Existential restriction modifier | 3 | 
| Infection causing inflammation of optic nerve | Finding site | True | Optic nerve structure | Inferred relationship | Existential restriction modifier | 1 | 
| Early-onset X-linked optic atrophy | Finding site | True | Optic nerve structure | Inferred relationship | Existential restriction modifier | 2 | 
| Optic neuropathy caused by ionizing radiation following radiotherapy procedure | Finding site | True | Optic nerve structure | Inferred relationship | Existential restriction modifier | 2 | 
| Growth retardation, alopecia, pseudoanodontia, optic atrophy syndrome | Finding site | False | Optic nerve structure | Inferred relationship | Existential restriction modifier | 7 | 
| Meningococcal optic neuritis | Finding site | False | Optic nerve structure | Inferred relationship | Existential restriction modifier | 2 | 
| Severe X-linked intellectual disability Gustavson type | Finding site | False | Optic nerve structure | Inferred relationship | Existential restriction modifier | 5 | 
| Aplasia of optic nerve | Finding site | True | Optic nerve structure | Inferred relationship | Existential restriction modifier | 1 | 
| Congenital atrophy of optic nerve | Finding site | True | Optic nerve structure | Inferred relationship | Existential restriction modifier | 1 | 
| Perioperative secondary non-arteritic ischemic optic neuropathy | Finding site | False | Optic nerve structure | Inferred relationship | Existential restriction modifier |  | 
| X-linked spastic paraplegia type 2 | Finding site | False | Optic nerve structure | Inferred relationship | Existential restriction modifier | 4 | 
| Structure of left optic nerve | Is a | True | Optic nerve structure | Inferred relationship | Existential restriction modifier |  | 
| Structure of right optic nerve | Is a | True | Optic nerve structure | Inferred relationship | Existential restriction modifier |  | 
| Spastic paraplegia, optic atrophy, neuropathy syndrome | Finding site | False | Optic nerve structure | Inferred relationship | Existential restriction modifier | 6 | 
| Cerebellar ataxia, intellectual disability, optic atrophy, skin abnormalities syndrome | Finding site | False | Optic nerve structure | Inferred relationship | Existential restriction modifier | 5 | 
| Isolated optic nerve hypoplasia | Finding site | True | Optic nerve structure | Inferred relationship | Existential restriction modifier | 1 | 
| Malignant optic glioma of adulthood | Finding site | False | Optic nerve structure | Inferred relationship | Existential restriction modifier | 1 | 
| Ischemic optic neuropathy | Finding site | True | Optic nerve structure | Inferred relationship | Existential restriction modifier | 1 | 
| Arteritic ischemic optic neuropathy | Finding site | True | Optic nerve structure | Inferred relationship | Existential restriction modifier | 1 | 
| Non-arteritic ischemic optic neuropathy | Finding site | True | Optic nerve structure | Inferred relationship | Existential restriction modifier | 1 | 
| Anterior ischemic optic neuropathy | Finding site | True | Optic nerve structure | Inferred relationship | Existential restriction modifier | 1 | 
| Posterior ischemic optic neuropathy | Finding site | True | Optic nerve structure | Inferred relationship | Existential restriction modifier | 1 | 
| Perioperative secondary non-arteritic ischemic optic neuropathy | Finding site | True | Optic nerve structure | Inferred relationship | Existential restriction modifier | 1 | 
| Arteritic anterior ischemic optic neuropathy | Finding site | True | Optic nerve structure | Inferred relationship | Existential restriction modifier | 1 | 
| Wolfram-like syndrome | Finding site | True | Optic nerve structure | Inferred relationship | Existential restriction modifier | 7 | 
| Progressive encephalopathy with edema, hypsarrhythmia and optic atrophy syndrome | Finding site | True | Optic nerve structure | Inferred relationship | Existential restriction modifier | 4 | 
| Combined immunodeficiency with faciooculoskeletal anomalies syndrome | Finding site | True | Optic nerve structure | Inferred relationship | Existential restriction modifier | 1 | 
| Optic atrophy, intellectual disability syndrome | Finding site | True | Optic nerve structure | Inferred relationship | Existential restriction modifier | 1 | 
| Polymicrogyria with optic nerve hypoplasia | Finding site | True | Optic nerve structure | Inferred relationship | Existential restriction modifier | 1 | 
| Optic nerve edema, splenomegaly syndrome | Finding site | True | Optic nerve structure | Inferred relationship | Existential restriction modifier | 1 | 
| Early-onset progressive neurodegeneration, blindness, ataxia, spasticity syndrome | Finding site | True | Optic nerve structure | Inferred relationship | Existential restriction modifier | 1 | 
| Severe X-linked intellectual disability Gustavson type | Finding site | True | Optic nerve structure | Inferred relationship | Existential restriction modifier | 3 | 
| Oculocerebral dysplasia syndrome | Finding site | False | Optic nerve structure | Inferred relationship | Existential restriction modifier | 1 | 
| Septo-optic dysplasia sequence | Finding site | False | Optic nerve structure | Inferred relationship | Existential restriction modifier | 2 | 
| Cerebellar ataxia, intellectual disability, optic atrophy, skin abnormalities syndrome | Finding site | True | Optic nerve structure | Inferred relationship | Existential restriction modifier | 2 | 
| Growth retardation, alopecia, pseudoanodontia, optic atrophy syndrome | Finding site | True | Optic nerve structure | Inferred relationship | Existential restriction modifier | 1 | 
| Infantile cerebellar and retinal degeneration | Finding site | True | Optic nerve structure | Inferred relationship | Existential restriction modifier | 3 | 
| Autosomal recessive optic atrophy type 7 | Finding site | True | Optic nerve structure | Inferred relationship | Existential restriction modifier | 1 | 
| Alcohol related optic neuropathy | Finding site | True | Optic nerve structure | Inferred relationship | Existential restriction modifier | 1 | 
| Autosomal recessive spastic ataxia, optic atrophy, dysarthria syndrome | Finding site | True | Optic nerve structure | Inferred relationship | Existential restriction modifier | 1 | 
| Fatal X-linked ataxia with deafness and loss of vision | Finding site | True | Optic nerve structure | Inferred relationship | Existential restriction modifier | 1 | 
| Neuromyelitis optica | Finding site | True | Optic nerve structure | Inferred relationship | Existential restriction modifier | 1 | 
| Autosomal recessive spastic paraplegia type 55 | Finding site | False | Optic nerve structure | Inferred relationship | Existential restriction modifier | 3 | 
| Autosomal recessive spastic paraplegia type 57 | Finding site | False | Optic nerve structure | Inferred relationship | Existential restriction modifier | 3 | 
| Spastic paraplegia, optic atrophy, neuropathy and spastic paraplegia, optic atrophy neuropathy-related disorder | Finding site | True | Optic nerve structure | Inferred relationship | Existential restriction modifier | 2 | 
| Arteritic anterior ischemic optic neuropathy due to giant cell arteritis | Finding site | True | Optic nerve structure | Inferred relationship | Existential restriction modifier | 1 | 
| Autosomal recessive optic atrophy type 6 | Finding site | True | Optic nerve structure | Inferred relationship | Existential restriction modifier | 1 | 
| Autoimmune optic neuropathy | Finding site | True | Optic nerve structure | Inferred relationship | Existential restriction modifier | 1 | 
| Childhood-onset autosomal dominant optic atrophy | Finding site | True | Optic nerve structure | Inferred relationship | Existential restriction modifier | 1 | 
| Idiopathic non-arteritic posterior ischemic optic neuropathy | Finding site | True | Optic nerve structure | Inferred relationship | Existential restriction modifier | 1 | 
| Idiopathic non-arteritic ischemic optic neuropathy | Finding site | True | Optic nerve structure | Inferred relationship | Existential restriction modifier | 1 | 
| Optic atrophy due to late syphilis | Finding site | True | Optic nerve structure | Inferred relationship | Existential restriction modifier | 1 | 
| Hypoplasia of optic nerve due to central nervous system malformation | Finding site | True | Optic nerve structure | Inferred relationship | Existential restriction modifier | 1 | 
| Optic nerve hypoplasia due to endocrine deficiency | Finding site | True | Optic nerve structure | Inferred relationship | Existential restriction modifier | 1 |