| Inbound Relationships | 
Type | 
Active | 
Source | 
Characteristic | 
Refinability | 
Group | 
| Tumor invades diaphragm (finding) | 
Interprets | 
True | 
Histopathology test (procedure) | 
Inferred relationship | 
Some | 
 2 | 
| Lymphatic (small vessel) intramural invasion by tumor present (finding) | 
Interprets | 
True | 
Histopathology test (procedure) | 
Inferred relationship | 
Some | 
 2 | 
| G1: Nuclei round, uniform, approximately 10 µ; nucleoli inconspicuous or absent | 
Interprets | 
True | 
Histopathology test (procedure) | 
Inferred relationship | 
Some | 
 2 | 
| Mitotic activity not applicable (finding) | 
Interprets | 
True | 
Histopathology test (procedure) | 
Inferred relationship | 
Some | 
 1 | 
| Tumor invades muscle (finding) | 
Interprets | 
True | 
Histopathology test (procedure) | 
Inferred relationship | 
Some | 
 2 | 
| Invasion of neoplasm to visceral peritoneum (finding) | 
Interprets | 
True | 
Histopathology test (procedure) | 
Inferred relationship | 
Some | 
 2 | 
| Vascular invasion by tumor present (finding) | 
Interprets | 
True | 
Histopathology test (procedure) | 
Inferred relationship | 
Some | 
 2 | 
| Blood/lymphatic vessel invasion by tumor indeterminate (breast) (finding) | 
Interprets | 
True | 
Histopathology test (procedure) | 
Inferred relationship | 
Some | 
 2 | 
| Tumor invades skin (finding) | 
Interprets | 
True | 
Histopathology test (procedure) | 
Inferred relationship | 
Some | 
 2 | 
| Tumor invades bone (finding) | 
Interprets | 
True | 
Histopathology test (procedure) | 
Inferred relationship | 
Some | 
 2 | 
| Intermediate grade histologic differentiation (finding) | 
Interprets | 
True | 
Histopathology test (procedure) | 
Inferred relationship | 
Some | 
 2 | 
| Tumor invasion finding (finding) | 
Interprets | 
True | 
Histopathology test (procedure) | 
Inferred relationship | 
Some | 
 2 | 
| Invasion of skeletal muscle by carcinoma (finding) | 
Interprets | 
True | 
Histopathology test (procedure) | 
Inferred relationship | 
Some | 
 2 | 
| G3: Poorly differentiated (5-49 percent gland forming) | 
Interprets | 
True | 
Histopathology test (procedure) | 
Inferred relationship | 
Some | 
 2 | 
| Tumor invasion into paratesticular structures | 
Interprets | 
True | 
Histopathology test (procedure) | 
Inferred relationship | 
Some | 
 2 | 
| Pleural invasion by tumor present (finding) | 
Interprets | 
True | 
Histopathology test (procedure) | 
Inferred relationship | 
Some | 
 2 | 
| Pleural invasion by tumor absent (finding) | 
Interprets | 
True | 
Histopathology test (procedure) | 
Inferred relationship | 
Some | 
 2 | 
| Nuclear pleomorphism: marked variation in size, nucleoli, chromatin clumping, etc (score = 3) (finding) | 
Interprets | 
True | 
Histopathology test (procedure) | 
Inferred relationship | 
Some | 
 1 | 
| Tumor invades head and neck (finding) | 
Interprets | 
True | 
Histopathology test (procedure) | 
Inferred relationship | 
Some | 
 2 | 
| Tumor invasion into mediastinal lymph node without extracapsular extension | 
Interprets | 
True | 
Histopathology test (procedure) | 
Inferred relationship | 
Some | 
 2 | 
| Lymphoma involves bone marrow (finding) | 
Interprets | 
True | 
Histopathology test (procedure) | 
Inferred relationship | 
Some | 
 2 | 
| Solid, entirely encapsulated tumor (finding) | 
Interprets | 
True | 
Histopathology test (procedure) | 
Inferred relationship | 
Some | 
 2 | 
| Tumor invasion of perineural tissue present (prostate) (finding) | 
Interprets | 
True | 
Histopathology test (procedure) | 
Inferred relationship | 
Some | 
 2 | 
| Breast tubule formation, minimal less than 10 percent (score = 3) (finding) | 
Interprets | 
True | 
Histopathology test (procedure) | 
Inferred relationship | 
Some | 
 1 | 
| No tumor invasion | 
Interprets | 
True | 
Histopathology test (procedure) | 
Inferred relationship | 
Some | 
 2 | 
| G1: 5 percent or less non-squamous solid growth (finding) | 
Interprets | 
True | 
Histopathology test (procedure) | 
Inferred relationship | 
Some | 
 2 | 
| G4: Undifferentiated (less than 5 percent gland forming) | 
Interprets | 
True | 
Histopathology test (procedure) | 
Inferred relationship | 
Some | 
 2 | 
| Tumor invades lens (finding) | 
Interprets | 
True | 
Histopathology test (procedure) | 
Inferred relationship | 
Some | 
 2 | 
| L1 stage | 
Interprets | 
True | 
Histopathology test (procedure) | 
Inferred relationship | 
Some | 
 2 | 
| G2 grade (finding) | 
Interprets | 
True | 
Histopathology test (procedure) | 
Inferred relationship | 
Some | 
 2 | 
| Pulmonary parenchymal invasion by tumor indeterminate (finding) | 
Interprets | 
True | 
Histopathology test (procedure) | 
Inferred relationship | 
Some | 
 2 | 
| Low grade (well to moderately differentiated) (finding) | 
Interprets | 
True | 
Histopathology test (procedure) | 
Inferred relationship | 
Some | 
 2 | 
| LX stage | 
Interprets | 
True | 
Histopathology test (procedure) | 
Inferred relationship | 
Some | 
 2 | 
| Arterial (large vessel) invasion by tumor indeterminate (finding) | 
Interprets | 
True | 
Histopathology test (procedure) | 
Inferred relationship | 
Some | 
 3 | 
| 1 or more mitotic figure per mm2 (finding) | 
Interprets | 
True | 
Histopathology test (procedure) | 
Inferred relationship | 
Some | 
 1 | 
| Tumor invades ciliary body (finding) | 
Interprets | 
True | 
Histopathology test (procedure) | 
Inferred relationship | 
Some | 
 2 | 
| Tumor present within 1mm of optic disc (finding) | 
Interprets | 
True | 
Histopathology test (procedure) | 
Inferred relationship | 
Some | 
 2 | 
| Tumor invades cornea (finding) | 
Interprets | 
True | 
Histopathology test (procedure) | 
Inferred relationship | 
Some | 
 2 | 
| No tumor invasion of adjacent tissue | 
Interprets | 
True | 
Histopathology test (procedure) | 
Inferred relationship | 
Some | 
 2 | 
| High grade histologic differentiation (finding) | 
Interprets | 
True | 
Histopathology test (procedure) | 
Inferred relationship | 
Some | 
 2 | 
| Tumor invades optic nerve to cut end of optic nerve (finding) | 
Interprets | 
True | 
Histopathology test (procedure) | 
Inferred relationship | 
Some | 
 2 | 
| Tumor extent of invasion cannot be determined (finding) | 
Interprets | 
True | 
Histopathology test (procedure) | 
Inferred relationship | 
Some | 
 2 | 
| Lymphoma involves muscular wall AND/OR subserosa (finding) | 
Interprets | 
True | 
Histopathology test (procedure) | 
Inferred relationship | 
Some | 
 2 | 
| Renal tumor invasion into adrenal gland macroscopically (finding) | 
Interprets | 
True | 
Histopathology test (procedure) | 
Inferred relationship | 
Some | 
 2 | 
| Tumor invades sclera (finding) | 
Interprets | 
True | 
Histopathology test (procedure) | 
Inferred relationship | 
Some | 
 2 | 
| Low grade (lymphoma) | 
Interprets | 
True | 
Histopathology test (procedure) | 
Inferred relationship | 
Some | 
 2 | 
| Tumor invasion into adjacent tissues | 
Interprets | 
True | 
Histopathology test (procedure) | 
Inferred relationship | 
Some | 
 2 | 
| < 4 mitoses/high power field | 
Interprets | 
True | 
Histopathology test (procedure) | 
Inferred relationship | 
Some | 
 1 | 
| Low grade lymphoma, stage 1 (finding) | 
Interprets | 
True | 
Histopathology test (procedure) | 
Inferred relationship | 
Some | 
 2 | 
| Lymphoma involves multiple lymph node regions (finding) | 
Interprets | 
True | 
Histopathology test (procedure) | 
Inferred relationship | 
Some | 
 2 | 
| Visceral pleura invasion by tumor absent (finding) | 
Interprets | 
True | 
Histopathology test (procedure) | 
Inferred relationship | 
Some | 
 2 | 
| Tumor invasion by site (finding) | 
Interprets | 
True | 
Histopathology test (procedure) | 
Inferred relationship | 
Some | 
 2 | 
| Renal tumor invasion into perinephric tissue macroscopically (finding) | 
Interprets | 
True | 
Histopathology test (procedure) | 
Inferred relationship | 
Some | 
 2 | 
| Tumor invasion into bronchus, invasive | 
Interprets | 
True | 
Histopathology test (procedure) | 
Inferred relationship | 
Some | 
 2 | 
| Large unstained cells | 
Interprets | 
True | 
Histopathology test (procedure) | 
Inferred relationship | 
Some | 
 1 | 
| Low grade histologic differentiation (finding) | 
Interprets | 
True | 
Histopathology test (procedure) | 
Inferred relationship | 
Some | 
 2 | 
| Tumor invades retroperitoneal structure (finding) | 
Interprets | 
True | 
Histopathology test (procedure) | 
Inferred relationship | 
Some | 
 2 | 
| Vascular invasion by tumor is indeterminate | 
Interprets | 
True | 
Histopathology test (procedure) | 
Inferred relationship | 
Some | 
 2 | 
| Poorly differentiated histological grade finding (finding) | 
Interprets | 
True | 
Histopathology test (procedure) | 
Inferred relationship | 
Some | 
 2 | 
| No mitotic activity (finding) | 
Interprets | 
True | 
Histopathology test (procedure) | 
Inferred relationship | 
Some | 
 1 | 
| Pulmonary parenchymal invasion by tumor cannot be assessed (finding) | 
Interprets | 
True | 
Histopathology test (procedure) | 
Inferred relationship | 
Some | 
 2 | 
| Tumor invasion into submucosa | 
Interprets | 
True | 
Histopathology test (procedure) | 
Inferred relationship | 
Some | 
 2 | 
| Greater than 4 mitoses per high power field (finding) | 
Interprets | 
True | 
Histopathology test (procedure) | 
Inferred relationship | 
Some | 
 1 | 
| Tumor invades subcutaneous tissue (finding) | 
Interprets | 
True | 
Histopathology test (procedure) | 
Inferred relationship | 
Some | 
 2 | 
| Nuclear grade finding (finding) | 
Interprets | 
True | 
Histopathology test (procedure) | 
Inferred relationship | 
Some | 
 1 | 
| Venous (large vessel)/lymphatic (small vessel) invasion by tumor cannot be assessed (finding) | 
Interprets | 
True | 
Histopathology test (procedure) | 
Inferred relationship | 
Some | 
 2 | 
| Nottingham Combined Grade I: 3-5 points | 
Interprets | 
True | 
Histopathology test (procedure) | 
Inferred relationship | 
Some | 
 1 | 
| Tumor invades optic nerve anterior to lamina cribrosa (finding) | 
Interprets | 
True | 
Histopathology test (procedure) | 
Inferred relationship | 
Some | 
 2 | 
| WHO grade III (central nervous system tumor) | 
Interprets | 
True | 
Histopathology test (procedure) | 
Inferred relationship | 
Some | 
 2 | 
| Lymphatic (small vessel) tumor invasion finding (finding) | 
Interprets | 
True | 
Histopathology test (procedure) | 
Inferred relationship | 
Some | 
 2 | 
| 10 or more mitotic figures per 10 high power field (finding) | 
Interprets | 
True | 
Histopathology test (procedure) | 
Inferred relationship | 
Some | 
 1 | 
| Visceral pleura invasion by tumor present (finding) | 
Interprets | 
True | 
Histopathology test (procedure) | 
Inferred relationship | 
Some | 
 2 | 
| Breslow measurement - depth from 0.76 to 1.75 mm (finding) | 
Interprets | 
True | 
Histopathology test (procedure) | 
Inferred relationship | 
Some | 
 2 | 
| Less than 10 mitoses per 10 HPF (score = 1) | 
Interprets | 
True | 
Histopathology test (procedure) | 
Inferred relationship | 
Some | 
 1 | 
| Local tumor invasion (finding) | 
Interprets | 
True | 
Histopathology test (procedure) | 
Inferred relationship | 
Some | 
 2 | 
| Lymphatic (small vessel) invasion by tumor present (finding) | 
Interprets | 
True | 
Histopathology test (procedure) | 
Inferred relationship | 
Some | 
 2 | 
| Scleral invasion by tumor cannot be determined (finding) | 
Interprets | 
True | 
Histopathology test (procedure) | 
Inferred relationship | 
Some | 
 2 | 
| Tumor invasion limited to dermis (finding) | 
Interprets | 
True | 
Histopathology test (procedure) | 
Inferred relationship | 
Some | 
 2 | 
| L2 stage | 
Interprets | 
True | 
Histopathology test (procedure) | 
Inferred relationship | 
Some | 
 2 | 
| Moderately differentiated histological grade finding (finding) | 
Interprets | 
True | 
Histopathology test (procedure) | 
Inferred relationship | 
Some | 
 2 | 
| Breslow depth finding for melanoma (finding) | 
Interprets | 
True | 
Histopathology test (procedure) | 
Inferred relationship | 
Some | 
 2 | 
| Seminal vesicle invasion by tumor present (finding) | 
Interprets | 
True | 
Histopathology test (procedure) | 
Inferred relationship | 
Some | 
 2 | 
| Nuclear pleomorphism finding (finding) | 
Interprets | 
True | 
Histopathology test (procedure) | 
Inferred relationship | 
Some | 
 1 | 
| WHO grade I (central nervous system tumor) | 
Interprets | 
True | 
Histopathology test (procedure) | 
Inferred relationship | 
Some | 
 2 | 
| V1 stage | 
Interprets | 
True | 
Histopathology test (procedure) | 
Inferred relationship | 
Some | 
 2 | 
| Nuclear pleomorphism: small regular nuclei (score=1) (finding) | 
Interprets | 
True | 
Histopathology test (procedure) | 
Inferred relationship | 
Some | 
 1 | 
| Arterial (large vessel) invasion by tumor present (finding) | 
Interprets | 
True | 
Histopathology test (procedure) | 
Inferred relationship | 
Some | 
 3 | 
| Tumor invades Schlemm's canal (finding) | 
Interprets | 
True | 
Histopathology test (procedure) | 
Inferred relationship | 
Some | 
 2 | 
| Finding addressing invasion of sclera by tumor (finding) | 
Interprets | 
True | 
Histopathology test (procedure) | 
Inferred relationship | 
Some | 
 2 | 
| Perineural invasion by tumor present (finding) | 
Interprets | 
True | 
Histopathology test (procedure) | 
Inferred relationship | 
Some | 
 2 | 
| Tumor invasion of sclera absent (finding) | 
Interprets | 
True | 
Histopathology test (procedure) | 
Inferred relationship | 
Some | 
 2 | 
| Nuclear pleomorphism, grade 1: monotonous nuclei, 1.5 - 2.0 RBC diameters, with finely dispersed chromatin and only occasional nucleoli | 
Interprets | 
True | 
Histopathology test (procedure) | 
Inferred relationship | 
Some | 
 1 | 
| Circumscribed tumor border | 
Interprets | 
True | 
Histopathology test (procedure) | 
Inferred relationship | 
Some | 
 2 | 
| Finding addressing invasion of optic nerve by tumor (finding) | 
Interprets | 
True | 
Histopathology test (procedure) | 
Inferred relationship | 
Some | 
 2 | 
| Less than or equal to 4 mitoses per high power field (finding) | 
Interprets | 
True | 
Histopathology test (procedure) | 
Inferred relationship | 
Some | 
 1 | 
| VX stage | 
Interprets | 
True | 
Histopathology test (procedure) | 
Inferred relationship | 
Some | 
 2 | 
| Small vessel invasion by tumor absent (finding) | 
Interprets | 
True | 
Histopathology test (procedure) | 
Inferred relationship | 
Some | 
 2 | 
| Extent of stromal invasion by tumor cannot be assessed (finding) | 
Interprets | 
True | 
Histopathology test (procedure) | 
Inferred relationship | 
Some | 
 2 | 
| G2: 6-50 percent non-squamous solid growth (finding) | 
Interprets | 
True | 
Histopathology test (procedure) | 
Inferred relationship | 
Some | 
 2 | 
| Tumor border behavior finding (finding) | 
Interprets | 
True | 
Histopathology test (procedure) | 
Inferred relationship | 
Some | 
 2 | 
| Perineural invasion by tumor not identified (finding) | 
Interprets | 
True | 
Histopathology test (procedure) | 
Inferred relationship | 
Some | 
 2 |