Inbound Relationships |
Type |
Active |
Source |
Characteristic |
Refinability |
Group |
Primary biliary cholangitis |
Finding site |
False |
Intrahepatic biliary tract structure |
Inferred relationship |
Some |
3 |
Reynolds syndrome (RS) is an autoimmune disorder characterized by the association of primary biliary cirrhosis (PBC) with limited cutaneous systemic sclerosis (lcSSc). |
Finding site |
False |
Intrahepatic biliary tract structure |
Inferred relationship |
Some |
5 |
Congenital paucity of intrahepatic bile ducts (disorder) |
Finding site |
False |
Intrahepatic biliary tract structure |
Inferred relationship |
Some |
1 |
Acquired paucity of intrahepatic bile ducts (disorder) |
Finding site |
False |
Intrahepatic biliary tract structure |
Inferred relationship |
Some |
1 |
Primary adenocarcinoma of intrahepatic bile duct (disorder) |
Finding site |
False |
Intrahepatic biliary tract structure |
Inferred relationship |
Some |
1 |
Histologic type of primary malignant neoplasm of intrahepatic bile duct (observable entity) |
This attribute specifies the location of the entity specified by the attribute "Inheres in". |
False |
Intrahepatic biliary tract structure |
Inferred relationship |
Some |
5 |
A type of progressive familial intrahepatic cholestasis, this disease is a severe, neonatal, hereditary disorder in bile formation that is hepatocellular in origin and not associated with extrahepatic features. Onset occurs in the neonatal period. Clinical signs of cholestasis usually appear in the first months of life with recurrent or permanent jaundice associated with hepatomegaly and severe pruritus. Patients usually develop fibrosis and end-stage liver disease before adulthood. PFIC2 is due to mutations in the ABCB11 gene (2q24) encoding the bile salt export pump (BSEP) protein resulting in impaired biliary bile acid secretion which leads to decreased bile flow and bile salt accumulation in hepatocytes with ongoing severe hepatocellular damage. |
Finding site |
True |
Intrahepatic biliary tract structure |
Inferred relationship |
Some |
1 |
An infantile hereditary disorder of bile formation that is hepatocellular in origin and associated with extrahepatic features. Onset occurs mostly during infancy with clinical signs of cholestasis with recurrent or permanent jaundice associated with hepatomegaly and severe pruritus. Caused by mutations in the ATP8B1 gene (18q21-22) encoding the FIC1 protein expressed at the canalicular membrane of hepatocytes as well as in other epithelia. Transmission is autosomal recessive. |
Finding site |
True |
Intrahepatic biliary tract structure |
Inferred relationship |
Some |
2 |
Histologic grade of primary malignant neoplasm of intrahepatic bile duct |
This attribute specifies the location of the entity specified by the attribute "Inheres in". |
False |
Intrahepatic biliary tract structure |
Inferred relationship |
Some |
5 |
Presence of direct invasion by primary malignant neoplasm of intrahepatic bile duct to nerve |
This attribute specifies the location of the entity specified by the attribute "Inheres in". |
False |
Intrahepatic biliary tract structure |
Inferred relationship |
Some |
7 |
Presence of direct invasion by primary malignant neoplasm of intrahepatic bile duct to lymphatic vessel and/or small blood vessel (observable entity) |
This attribute specifies the location of the entity specified by the attribute "Inheres in". |
False |
Intrahepatic biliary tract structure |
Inferred relationship |
Some |
7 |
Anatomic location directly invaded by primary malignant neoplasm of intrahepatic bile duct (observable entity) |
This attribute specifies the location of the entity specified by the attribute "Inheres in". |
False |
Intrahepatic biliary tract structure |
Inferred relationship |
Some |
6 |
Calculus of intrahepatic bile duct |
Finding site |
False |
Intrahepatic biliary tract structure |
Inferred relationship |
Some |
1 |
The number of distinct, individual primary malignant neoplasms in an intrahepatic bile duct specimen represented as either focal (single) or multifocal (multiple), and not as a discrete number. |
This attribute specifies the location of the entity specified by the attribute "Inheres in". |
False |
Intrahepatic biliary tract structure |
Inferred relationship |
Some |
6 |
Presence of primary malignant neoplasm of intrahepatic bile duct at bile duct surgical margin in liver tissue specimen (observable entity) |
This attribute specifies the location of the entity specified by the attribute "Inheres in". |
False |
Intrahepatic biliary tract structure |
Inferred relationship |
Some |
7 |
Presence of primary malignant neoplasm of intrahepatic bile duct at hepatic parenchymal surgical margin in excised liver tissue specimen |
This attribute specifies the location of the entity specified by the attribute "Inheres in". |
False |
Intrahepatic biliary tract structure |
Inferred relationship |
Some |
7 |
Presence of primary malignant neoplasm of intrahepatic bile duct at surgical margin in liver tissue specimen (observable entity) |
This attribute specifies the location of the entity specified by the attribute "Inheres in". |
False |
Intrahepatic biliary tract structure |
Inferred relationship |
Some |
7 |
Surgical margin involved by primary malignant neoplasm of intrahepatic bile duct in excised liver specimen |
This attribute specifies the location of the entity specified by the attribute "Inheres in". |
False |
Intrahepatic biliary tract structure |
Inferred relationship |
Some |
7 |
Progressive familial intrahepatic cholestasis type 3 |
Finding site |
True |
Intrahepatic biliary tract structure |
Inferred relationship |
Some |
2 |
Benign intrahepatic cholestasis type 2 |
Finding site |
True |
Intrahepatic biliary tract structure |
Inferred relationship |
Some |
1 |
Bile duct adenoma of intrahepatic bile duct (disorder) |
Finding site |
False |
Intrahepatic biliary tract structure |
Inferred relationship |
Some |
1 |
Primary cystadenocarcinoma of intrahepatic bile duct (disorder) |
Finding site |
False |
Intrahepatic biliary tract structure |
Inferred relationship |
Some |
1 |
Intrahepatic cholangitis due to intrahepatic cholelithiasis |
Finding site |
False |
Intrahepatic biliary tract structure |
Inferred relationship |
Some |
1 |
Structure of wall of intrahepatic biliary tract |
Is a |
True |
Intrahepatic biliary tract structure |
Inferred relationship |
Some |
|
A rare biliary tract disease characterized by stone formation within the intrahepatic bile ducts without any known cause, leading to bile stasis and repeated cholangitic episodes. The condition is rare in the Western world but frequent in eastern Asia. Patients usually present before the age of forty with right upper quadrant pain, jaundice, and/or fever. Stones are typically calcium bilirubinate (pigment) stones, and bacteria are present in the bile in almost all cases. Complications are biliary strictures, liver abscess, liver fibrosis, and secondary biliary cirrhosis. Association with cholangiocarcinoma has also been reported. |
Finding site |
False |
Intrahepatic biliary tract structure |
Inferred relationship |
Some |
1 |
Metastatic carcinoma to intrahepatic bile duct (disorder) |
Finding site |
False |
Intrahepatic biliary tract structure |
Inferred relationship |
Some |
1 |
Metastatic squamous cell carcinoma to liver and intrahepatic biliary tract |
Finding site |
True |
Intrahepatic biliary tract structure |
Inferred relationship |
Some |
1 |
Primary intrahepatic bile duct carcinoma |
Finding site |
False |
Intrahepatic biliary tract structure |
Inferred relationship |
Some |
1 |
Cholangiocarcinoma of intrahepatic biliary tract (disorder) |
Finding site |
True |
Intrahepatic biliary tract structure |
Inferred relationship |
Some |
1 |
Surgical margin closest to primary malignant neoplasm of intrahepatic bile duct in excised specimen (observable entity) |
This attribute specifies the location of the entity specified by the attribute "Inheres in". |
False |
Intrahepatic biliary tract structure |
Inferred relationship |
Some |
8 |
Metastatic undifferentiated carcinoma to liver and intrahepatic biliary tract (disorder) |
Finding site |
True |
Intrahepatic biliary tract structure |
Inferred relationship |
Some |
1 |
Primary undifferentiated carcinoma of liver and intrahepatic biliary tract (disorder) |
Finding site |
True |
Intrahepatic biliary tract structure |
Inferred relationship |
Some |
1 |
Primary squamous cell carcinoma of liver and intrahepatic biliary tract |
Finding site |
True |
Intrahepatic biliary tract structure |
Inferred relationship |
Some |
1 |
Presence of high grade glandular intraepithelial neoplasia at surgical margin in excised specimen of intrahepatic bile duct (observable entity) |
This attribute specifies the location of the entity specified by the attribute "Inheres in". |
False |
Intrahepatic biliary tract structure |
Inferred relationship |
Some |
7 |
Drug-induced intrahepatic cholestasis |
Finding site |
True |
Intrahepatic biliary tract structure |
Inferred relationship |
Some |
1 |
Cholestasis of pregnancy |
Finding site |
True |
Intrahepatic biliary tract structure |
Inferred relationship |
Some |
1 |
Intrahepatic cholestasis |
Finding site |
True |
Intrahepatic biliary tract structure |
Inferred relationship |
Some |
1 |
Cholestasis of pregnancy complicating childbirth |
Finding site |
True |
Intrahepatic biliary tract structure |
Inferred relationship |
Some |
1 |
A mild subtype of citrin deficiency characterized clinically by low birth weight, failure to thrive, transient intrahepatic cholestasis, multiple aminoacidemia, galactosemia, hypoproteinemia, hepatomegaly, decreased coagulation factors, hemolytic anemia, variable but mostly mild liver dysfunction, and hypoglycemia. |
Finding site |
True |
Intrahepatic biliary tract structure |
Inferred relationship |
Some |
3 |
Severe autosomal recessive intrahepatic cholestasis described in aboriginal children from northwestern Quebec. First manifestation as neonatal jaundice, progresses to periportal fibrosis and cirrhosis. |
Finding site |
True |
Intrahepatic biliary tract structure |
Inferred relationship |
Some |
3 |
The number of distinct, individual primary malignant neoplasms in an intrahepatic bile duct specimen represented as either focal (single) or multifocal (multiple), and not as a discrete number. |
This attribute specifies the independent continuant which bears the quality, and on which the dependent quality (of this observable) depends. |
False |
Intrahepatic biliary tract structure |
Inferred relationship |
Some |
6 |
Disease with characteristics of early childhood onset of severe progressive liver disease. Caused by homozygous or compound heterozygous mutation in the TJP2 gene on chromosome 9q21. |
Finding site |
True |
Intrahepatic biliary tract structure |
Inferred relationship |
Some |
2 |
Anatomic location directly invaded by primary malignant neoplasm of intrahepatic bile duct (observable entity) |
This attribute specifies the location of the entity specified by the attribute "Inheres in". |
True |
Intrahepatic biliary tract structure |
Inferred relationship |
Some |
1 |
Histologic grade of primary malignant neoplasm of intrahepatic bile duct |
This attribute specifies the location of the entity specified by the attribute "Inheres in". |
True |
Intrahepatic biliary tract structure |
Inferred relationship |
Some |
1 |
Histologic type of primary malignant neoplasm of intrahepatic bile duct (observable entity) |
This attribute specifies the location of the entity specified by the attribute "Inheres in". |
True |
Intrahepatic biliary tract structure |
Inferred relationship |
Some |
1 |
Presence of direct invasion by primary malignant neoplasm of intrahepatic bile duct to nerve |
This attribute specifies the location of the entity specified by the attribute "Inheres in". |
True |
Intrahepatic biliary tract structure |
Inferred relationship |
Some |
1 |
Presence of direct invasion by primary malignant neoplasm of intrahepatic bile duct to lymphatic vessel and/or small blood vessel (observable entity) |
This attribute specifies the location of the entity specified by the attribute "Inheres in". |
True |
Intrahepatic biliary tract structure |
Inferred relationship |
Some |
1 |
Presence of high grade glandular intraepithelial neoplasia at surgical margin in excised specimen of intrahepatic bile duct (observable entity) |
This attribute specifies the location of the entity specified by the attribute "Inheres in". |
True |
Intrahepatic biliary tract structure |
Inferred relationship |
Some |
1 |
Presence of primary malignant neoplasm of intrahepatic bile duct at bile duct surgical margin in liver tissue specimen (observable entity) |
This attribute specifies the location of the entity specified by the attribute "Inheres in". |
True |
Intrahepatic biliary tract structure |
Inferred relationship |
Some |
1 |
Presence of primary malignant neoplasm of intrahepatic bile duct at hepatic parenchymal surgical margin in excised liver tissue specimen |
This attribute specifies the location of the entity specified by the attribute "Inheres in". |
True |
Intrahepatic biliary tract structure |
Inferred relationship |
Some |
1 |
Presence of primary malignant neoplasm of intrahepatic bile duct at surgical margin in liver tissue specimen (observable entity) |
This attribute specifies the location of the entity specified by the attribute "Inheres in". |
True |
Intrahepatic biliary tract structure |
Inferred relationship |
Some |
1 |
The number of distinct, individual primary malignant neoplasms in an intrahepatic bile duct specimen represented as either focal (single) or multifocal (multiple), and not as a discrete number. |
This attribute specifies the independent continuant which bears the quality, and on which the dependent quality (of this observable) depends. |
True |
Intrahepatic biliary tract structure |
Inferred relationship |
Some |
1 |
Surgical margin closest to primary malignant neoplasm of intrahepatic bile duct in excised specimen (observable entity) |
This attribute specifies the location of the entity specified by the attribute "Inheres in". |
True |
Intrahepatic biliary tract structure |
Inferred relationship |
Some |
1 |
Surgical margin involved by primary malignant neoplasm of intrahepatic bile duct in excised liver specimen |
This attribute specifies the location of the entity specified by the attribute "Inheres in". |
True |
Intrahepatic biliary tract structure |
Inferred relationship |
Some |
1 |
Structure of intrahepatic bile duct (body structure) |
Is a |
True |
Intrahepatic biliary tract structure |
Inferred relationship |
Some |
|
Entire intrahepatic biliary tree (body structure) |
Is a |
True |
Intrahepatic biliary tract structure |
Inferred relationship |
Some |
|
Cholestasis of parenteral nutrition (disorder) |
Finding site |
True |
Intrahepatic biliary tract structure |
Inferred relationship |
Some |
2 |