418143002: Cerebral degeneration (disorder)

SNOMED CT Concept\Clinical finding (finding)\...

\Head finding (finding)\Finding of brain\Disorder of brain (disorder)\Degenerative brain disorder\Cerebral degeneration (disorder)
\Head finding (finding)\Disorder of head (disorder)\Disorder of brain (disorder)\Degenerative brain disorder\Cerebral degeneration (disorder)

\Central nervous system finding\Finding of brain\Disorder of brain (disorder)\Degenerative brain disorder\Cerebral degeneration (disorder)
\Central nervous system finding\Disorder of the central nervous system (disorder)\Disorder of brain (disorder)\Degenerative brain disorder\Cerebral degeneration (disorder)
\Central nervous system finding\Disorder of the central nervous system (disorder)\Degenerative disease of the central nervous system\Degenerative brain disorder\Cerebral degeneration (disorder)

\Disease\Degenerative disorder\Degenerative disease of the central nervous system\Degenerative brain disorder\Cerebral degeneration (disorder)
\Disease\Disorder of body system\Disorder of nervous system (disorder)\Disorder of the central nervous system (disorder)\Disorder of brain (disorder)\Degenerative brain disorder\Cerebral degeneration (disorder)
\Disease\Disorder of body system\Disorder of nervous system (disorder)\Disorder of the central nervous system (disorder)\Degenerative disease of the central nervous system\Degenerative brain disorder\Cerebral degeneration (disorder)
\Disease\Disorder of head (disorder)\Disorder of brain (disorder)\Degenerative brain disorder\Cerebral degeneration (disorder)

Status: current, Sufficiently defined by necessary conditions definition status (core metadata concept). Date: 31-Jan 2006. Module: SNOMED CT core

Descriptions:

Id Description Lang Type Status Case? Module

2574464019 Cerebral degeneration (disorder) en Fully specified name Active Entire term case insensitive (core metadata concept) SNOMED CT core

2577820013 Cerebral degeneration en Synonym (core metadata concept) Active Entire term case insensitive (core metadata concept) SNOMED CT core

3499981000005111 cerebral degeneration da Synonym (core metadata concept) Active Entire term case insensitive (core metadata concept) Danish module (core metadata concept)

Expanded Value Set

Outbound Relationships	Type	Target	Active	Characteristic	Refinability	Group	Values
Cerebral degeneration (disorder)	Is a	Degenerative brain disorder	true	Inferred relationship	Some
Cerebral degeneration (disorder)	Associated morphology	Degeneration	false	Inferred relationship	Some	1
Cerebral degeneration (disorder)	Finding site	The cerebrum is the regional structure of the brain, which is the adult equivalent of the forebrain or prosencephalon. It is constituted by the structural derivatives of the telencephalon and diencephalon including the cerebral hemispheres, epithalamus, thalamus, hypothalamus, lateral ventricles and third ventricle. This definition is harmonious with the Federation of Association of Anatomist Second Edition (2019) Part V Terminologia Anatomica.	false	Inferred relationship	Some	1
Cerebral degeneration (disorder)	Associated morphology	Degeneration	false	Inferred relationship	Some	1
Cerebral degeneration (disorder)	Finding site	The cerebrum is the regional structure of the brain, which is the adult equivalent of the forebrain or prosencephalon. It is constituted by the structural derivatives of the telencephalon and diencephalon including the cerebral hemispheres, epithalamus, thalamus, hypothalamus, lateral ventricles and third ventricle. This definition is harmonious with the Federation of Association of Anatomist Second Edition (2019) Part V Terminologia Anatomica.	true	Inferred relationship	Some	1
Cerebral degeneration (disorder)	Associated morphology	Degenerative abnormality	true	Inferred relationship	Some	1

Inbound Relationships	Type	Active	Source	Characteristic	Refinability	Group
Frontotemporal degeneration	Is a	True	Cerebral degeneration (disorder)	Inferred relationship	Some
Chronic hepatocerebral degeneration	Is a	True	Cerebral degeneration (disorder)	Inferred relationship	Some
Frontal lobe degeneration	Is a	True	Cerebral degeneration (disorder)	Inferred relationship	Some
Cerebral degeneration presenting primarily with dementia (disorder)	Is a	True	Cerebral degeneration (disorder)	Inferred relationship	Some
Corticobasal degeneration	Is a	True	Cerebral degeneration (disorder)	Inferred relationship	Some
Cerebral degeneration in childhood	Is a	True	Cerebral degeneration (disorder)	Inferred relationship	Some
Pigmentary pallidal degeneration	Is a	True	Cerebral degeneration (disorder)	Inferred relationship	Some
Cerebral degeneration associated with another disorder (disorder)	Is a	True	Cerebral degeneration (disorder)	Inferred relationship	Some
Striatonigral degeneration	Is a	True	Cerebral degeneration (disorder)	Inferred relationship	Some
Progressive supranuclear ophthalmoplegia	Is a	True	Cerebral degeneration (disorder)	Inferred relationship	Some
A rare neurologic disease characterized by impairment of higher visual processing skills and other posterior cortical functions without any evidence of ocular abnormalities, relatively intact memory and language in the early stages, and atrophy of posterior brain regions.	Is a	True	Cerebral degeneration (disorder)	Inferred relationship	Some
Kuru	Is a	False	Cerebral degeneration (disorder)	Inferred relationship	Some
Spongiform encephalopathy	Is a	True	Cerebral degeneration (disorder)	Inferred relationship	Some
An adult-onset movement disorder characterized by bradykinesia, dysarthria and muscle rigidity.	Is a	True	Cerebral degeneration (disorder)	Inferred relationship	Some
A rare late-onset neurodegenerative disease with characteristics of supranuclear gaze palsy, postural instability, progressive rigidity, and mild dementia. Five clinical variants have been described with clinicopathological correlations, with Richardson's syndrome the most common clinical variant. The disease has neuropathological manifestations of neuronal loss, gliosis with astrocytic plaques and accumulation of tau-immunoreactive neurofibrillary tangles in specific brain areas. The differences in the rate and areas of accumulation of phosphorylated tau protein correlate with the five clinical variants. The disease is a 4R tauopathy composed of a preponderance of four-repeat (exon 10 positive) tau isoforms and a characteristic biochemical profile (doublet tau 64 and tau 69). The MAPT H1-clade specific sub-haplotype, H1c, is a risk factor for this disease.	Is a	True	Cerebral degeneration (disorder)	Inferred relationship	Some
A rare genetic neurodegenerative disease characterised by movement disorders, including dystonia, chorea, myoclonus, tremor and rigidity. Associated features are also cognitive and memory impairment, early psychiatric disturbances and behavioural problems.	Is a	True	Cerebral degeneration (disorder)	Inferred relationship	Some
A rare genetic neuronal ceroid lipofuscinosis disorder with characteristics of infantile to early childhood onset of progressive myoclonic seizures (occasionally accompanied by generalised tonic-clonic seizures) and severe progressive neurological regression, leading to psychomotor and cognitive decline, cerebellar ataxia, dementia and, frequently, early death. Vision loss may be associated. EEG typically reveals epileptiform activity with predominance in the posterior region and photosensitivity. Caused by homozygous or compound heterozygous mutation in the KCTD7 gene on chromosome 7q11.	Is a	True	Cerebral degeneration (disorder)	Inferred relationship	Some
A rare genetic human prion disease characterised by adult-onset neurodegenerative manifestations associated with a movement disorder and psychiatric/behavioural disturbances. Patients typically present personality changes, aggressiveness, manias, anxiety and/or depression in conjunction with rapidly progressive cognitive decline (presenting with dysarthria, apraxia, aphasia and eventually leading to dementia) as well as ataxia (manifesting with gait disturbances, unsteadiness, coordination problems), Parkinsonism, myoclonus, and/or chorea. Additional features may include generalised spasticity, seizures, urine incontinence and pyramidal abnormalities. There is evidence the disease is caused by 8 extra octapeptide repeats in the PRNP gene on chromosome 20p13.	Is a	True	Cerebral degeneration (disorder)	Inferred relationship	Some
White matter disease (disorder)	Is a	True	Cerebral degeneration (disorder)	Inferred relationship	Some
Neuroaxonal leukodystrophy (disorder)	Is a	True	Cerebral degeneration (disorder)	Inferred relationship	Some
Cerebral calcification	Is a	True	Cerebral degeneration (disorder)	Inferred relationship	Some
Cerebral atrophy	Is a	True	Cerebral degeneration (disorder)	Inferred relationship	Some
Parkinson's disease	Is a	True	Cerebral degeneration (disorder)	Inferred relationship	Some
Onset of disease between 2 and 5 years of age with characteristics of cerebello-spastic syndrome exacerbated by episodes of fever or head trauma leading to death after 5 to 10 years of disease evolution, diffuse involvement of the white matter on cerebral MRI with a CSF-like signal intensity (cavitation), a recessive autosomal mode of inheritance, neuropathologic findings consistent with a cavitating orthochromatic leukodystrophy with increased number of oligodendrocytes. This disease is linked to mutations in the five EIF2B genes encoding the five subunits of the eukaryotic initiation factor 2B (eIF2B), involved in the protein synthesis and its regulation under cellular stress.	Is a	True	Cerebral degeneration (disorder)	Inferred relationship	Some
A rare genetic neurological disorder characterized by the association of hypomyelinating leukodystrophy with spondylometaphyseal dysplasia. Patients present in infancy with absent or delayed ability to walk independently, slowly progressive motor deterioration, spasticity, ataxia, proximal weakness, and joint contractures. Additional manifestations include mild cognitive impairment, short stature, scoliosis, enlarged and deformed joints, dysarthria, nystagmus, visual defects, and mildly dysmorphic features, among others. Mode of inheritance is X-linked recessive.	Is a	True	Cerebral degeneration (disorder)	Inferred relationship	Some
Pituitary degeneration	Is a	True	Cerebral degeneration (disorder)	Inferred relationship	Some
Cerebral non-neuropathic heredofamilial amyloidosis angiopathy	Is a	False	Cerebral degeneration (disorder)	Inferred relationship	Some
Degeneration of pineal gland (disorder)	Is a	True	Cerebral degeneration (disorder)	Inferred relationship	Some
A rare neurologic disease characterized by multifaceted motor system dysfunctions and cognitive defects such as asymmetric rigidity, bradykinesia, limb apraxia, and visuospatial dysfunction.	Is a	True	Cerebral degeneration (disorder)	Inferred relationship	Some
A rare severe neurodegenerative disorder that is considered one of the phenocopies of Huntington Disease (HD) affecting patients of African descent and characterized by a triad of movement (chorea, oculomotor, parkinsonism), psychiatric (prominently sadness, irritability and anxiety), and cognitive abnormalities (early cognitive decline and subcortical-like dementia).	Is a	True	Cerebral degeneration (disorder)	Inferred relationship	Some
A rare parkinsonian syndrome due to neurodegenerative disease characterised by resting tremor (which may initially be asymmetric), rigidity, and bradykinesia. Polyneuropathy with neurogenic electromyography findings is present in the majority of the patients and reported in young age (early twenties) whereas parkinsonian symptoms are visible later in life (between 40 and 70 years of age). Additional clinical symptoms may include anxiety and depression. Mild diffuse muscular atrophy can also be detected in some patients.	Is a	True	Cerebral degeneration (disorder)	Inferred relationship	Some

Reference Sets

GB English

US English

Back to Start

Id	Description	Lang	Type	Status	Case?	Module
2574464019	Cerebral degeneration (disorder)	en	Fully specified name	Active	Entire term case insensitive (core metadata concept)	SNOMED CT core
2577820013	Cerebral degeneration	en	Synonym (core metadata concept)	Active	Entire term case insensitive (core metadata concept)	SNOMED CT core
3499981000005111	cerebral degeneration	da	Synonym (core metadata concept)	Active	Entire term case insensitive (core metadata concept)	Danish module (core metadata concept)