412631008: Tau protein (substance)

SNOMED CT Concept\Substance\...

\Substance categorised by structure\Chemical\Chemical categorized by structure (substance)\...

\Nitrogen and/or nitrogen compound (substance)\Nitrogen compound\Organic nitrogen compound\Amide and/or amide derivative (substance)\Substituted amide (substance)\Polypeptide\Protein\Tau protein (substance)

\Organic compound\Organic nitrogen compound\Amide and/or amide derivative (substance)\Substituted amide (substance)\Polypeptide\Protein\Tau protein (substance)

\Biological substance (substance)\Protein and/or protein derivative\Protein\Tau protein (substance)
\Biological substance (substance)\Polypeptide\Protein\Tau protein (substance)

Status: current, Not sufficiently defined by necessary conditions definition status (core metadata concept). Date: 31-Jul 2004. Module: SNOMED CT core

Descriptions:

Id Description Lang Type Status Case? Module

2468083018 Tau protein (substance) en Fully specified name Active Entire term case insensitive (core metadata concept) SNOMED CT core

2474191017 Tau protein en Synonym (core metadata concept) Active Entire term case insensitive (core metadata concept) SNOMED CT core

2478405017 Microtubule protein tau en Synonym (core metadata concept) Active Entire term case insensitive (core metadata concept) SNOMED CT core

2478406016 Microtubule associated tau protein en Synonym (core metadata concept) Active Entire term case insensitive (core metadata concept) SNOMED CT core

2478407013 Tau factor en Synonym (core metadata concept) Active Entire term case insensitive (core metadata concept) SNOMED CT core

Expanded Value Set

Outbound Relationships	Type	Target	Active	Characteristic	Refinability	Group	Values
Tau protein (substance)	Is a	Protein	true	Inferred relationship	Some

Inbound Relationships	Type	Active	Source	Characteristic	Refinability	Group
Cerebrospinal fluid Tau protein measurement (procedure)	Component	False	Tau protein (substance)	Inferred relationship	Some	2
Fluid sample Tau protein measurement (procedure)	Component	False	Tau protein (substance)	Inferred relationship	Some	2
Tau protein, phosphorylated 181	Is a	True	Tau protein (substance)	Inferred relationship	Some
A rare late-onset neurodegenerative disease with characteristics of supranuclear gaze palsy, postural instability, progressive rigidity, and mild dementia. Five clinical variants have been described with clinicopathological correlations, with Richardson's syndrome the most common clinical variant. The disease has neuropathological manifestations of neuronal loss, gliosis with astrocytic plaques and accumulation of tau-immunoreactive neurofibrillary tangles in specific brain areas. The differences in the rate and areas of accumulation of phosphorylated tau protein correlate with the five clinical variants. The disease is a 4R tauopathy composed of a preponderance of four-repeat (exon 10 positive) tau isoforms and a characteristic biochemical profile (doublet tau 64 and tau 69). The MAPT H1-clade specific sub-haplotype, H1c, is a risk factor for this disease.	Causative agent	True	Tau protein (substance)	Inferred relationship	Some	1
Atypical progressive supranuclear palsy syndrome	Causative agent	True	Tau protein (substance)	Inferred relationship	Some	1
Progressive supranuclear palsy corticobasal syndrome (disorder)	Causative agent	True	Tau protein (substance)	Inferred relationship	Some	2
Progressive supranuclear palsy parkinsonism syndrome (disorder)	Causative agent	True	Tau protein (substance)	Inferred relationship	Some	1
Progressive supranuclear palsy progressive non fluent aphasia	Causative agent	True	Tau protein (substance)	Inferred relationship	Some	1
Fluid sample Tau protein measurement (procedure)	Component	True	Tau protein (substance)	Inferred relationship	Some	1
Cerebrospinal fluid Tau protein measurement (procedure)	Component	True	Tau protein (substance)	Inferred relationship	Some	1

Reference Sets