387208003: Isotretinoin (substance)

SNOMED CT Concept\Substance\...

\A grouper concept for substances that are used in medicinal products for medical treatment, and also psychoactive substances that have few or no legitimate medical uses or that are not legally available to the person using them.\Retinoid (substance)\Isotretinoin (substance)

\Substance categorised by structure\Chemical\Chemical categorized by structure (substance)\Organic compound\Hydrocarbon\Terpene (substance)\Carotinoid (substance)\Retinoid (substance)\Isotretinoin (substance)

Status: current, Not sufficiently defined by necessary conditions definition status (core metadata concept). Date: 31-Jan 2003. Module: SNOMED CT core

Descriptions:

Expanded Value Set

Outbound Relationships	Type	Target	Active	Characteristic	Refinability	Group	Values
Isotretinoin (substance)	Is a	Retinoid (substance)	true	Inferred relationship	Some
Isotretinoin (substance)	Is a	Tretinoin (substance)	false	Inferred relationship	Some

Inbound Relationships	Type	Active	Source	Characteristic	Refinability	Group
Isotretinoin measurement	Component	True	Isotretinoin (substance)	Inferred relationship	Some	1
Isotretinoin adverse reaction (disorder)	Causative agent	True	Isotretinoin (substance)	Inferred relationship	Some	1
Allergy to isotretinoin	Causative agent	False	Isotretinoin (substance)	Inferred relationship	Some
Isotretinoin overdose	Causative agent	True	Isotretinoin (substance)	Inferred relationship	Some	1
Accidental isotretinoin overdose	Causative agent	True	Isotretinoin (substance)	Inferred relationship	Some	1
Intentional isotretinoin overdose	Causative agent	True	Isotretinoin (substance)	Inferred relationship	Some	1
overdosis af isotretinion, uvist med hvilken hensigt	Causative agent	False	Isotretinoin (substance)	Inferred relationship	Some	1
Isotretinoin [topical]	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Isotretinoin (substance)	Inferred relationship	Some
Product containing precisely erythromycin 20 milligram/1 gram and isotretinoin 500 microgram/1 gram conventional release cutaneous gel (clinical drug)	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Isotretinoin (substance)	Inferred relationship	Some
Product containing precisely isotretinoin 5 milligram/1 each conventional release oral capsule (clinical drug)	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Isotretinoin (substance)	Inferred relationship	Some
Product containing precisely isotretinoin 20 milligram/1 each conventional release oral capsule (clinical drug)	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Isotretinoin (substance)	Inferred relationship	Some
Product containing precisely isotretinoin 500 microgram/1 gram conventional release cutaneous gel (clinical drug)	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Isotretinoin (substance)	Inferred relationship	Some
Retinoinsyreembryopati	Causative agent	False	Isotretinoin (substance)	Inferred relationship	Some
Product containing precisely isotretinoin 10 milligram/1 each conventional release oral capsule (clinical drug)	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Isotretinoin (substance)	Inferred relationship	Some
Product containing precisely isotretinoin 40 milligram/1 each conventional release oral capsule (clinical drug)	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Isotretinoin (substance)	Inferred relationship	Some
Product containing isotretinoin (medicinal product)	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	True	Isotretinoin (substance)	Inferred relationship	Some	1
Product containing erythromycin and isotretinoin (medicinal product)	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	True	Isotretinoin (substance)	Inferred relationship	Some	2
Isotretinoin 30 mg oral capsule	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Isotretinoin (substance)	Inferred relationship	Some
isotretinoin til topikal anvendelse	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Isotretinoin (substance)	Inferred relationship	Some
Product containing isotretinoin in oral dose form (medicinal product form)	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	True	Isotretinoin (substance)	Inferred relationship	Some	1
Allergy to isotretinoin	Causative agent	True	Isotretinoin (substance)	Inferred relationship	Some	1
Isotretinoin therapy (procedure)	Direct substance	True	Isotretinoin (substance)	Inferred relationship	Some	2
Product containing precisely isotretinoin 5 milligram/1 each conventional release oral capsule (clinical drug)	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Isotretinoin (substance)	Inferred relationship	Some	1
Product containing precisely isotretinoin 5 milligram/1 each conventional release oral capsule (clinical drug)	This attribute represents an ingredient that is the part of the active ingredient that the strength of a given product is based upon.	True	Isotretinoin (substance)	Inferred relationship	Some	1
Product containing precisely isotretinoin 20 milligram/1 each conventional release oral capsule (clinical drug)	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Isotretinoin (substance)	Inferred relationship	Some	1
Product containing precisely isotretinoin 20 milligram/1 each conventional release oral capsule (clinical drug)	This attribute represents an ingredient that is the part of the active ingredient that the strength of a given product is based upon.	True	Isotretinoin (substance)	Inferred relationship	Some	1
Product containing precisely isotretinoin 10 milligram/1 each conventional release oral capsule (clinical drug)	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Isotretinoin (substance)	Inferred relationship	Some	1
Product containing precisely isotretinoin 10 milligram/1 each conventional release oral capsule (clinical drug)	This attribute represents an ingredient that is the part of the active ingredient that the strength of a given product is based upon.	True	Isotretinoin (substance)	Inferred relationship	Some	1
Product containing precisely isotretinoin 40 milligram/1 each conventional release oral capsule (clinical drug)	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Isotretinoin (substance)	Inferred relationship	Some	1
Product containing precisely isotretinoin 40 milligram/1 each conventional release oral capsule (clinical drug)	This attribute represents an ingredient that is the part of the active ingredient that the strength of a given product is based upon.	True	Isotretinoin (substance)	Inferred relationship	Some	1
Isotretinoin 30 mg oral capsule	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Isotretinoin (substance)	Inferred relationship	Some	1
Isotretinoin 30 mg oral capsule	This attribute represents an ingredient that is the part of the active ingredient that the strength of a given product is based upon.	True	Isotretinoin (substance)	Inferred relationship	Some	1
Product containing precisely isotretinoin 10 milligram/1 each conventional release oral capsule (clinical drug)	The most specific description of a substance present in the manufactured dose form, before any dilution or transformation. It includes modifiers, such as salts, esters, polymers (e.g. pegylation), and/or solvates (including waters of hydration).	True	Isotretinoin (substance)	Inferred relationship	Some	1
Product containing precisely isotretinoin 5 milligram/1 each conventional release oral capsule (clinical drug)	The most specific description of a substance present in the manufactured dose form, before any dilution or transformation. It includes modifiers, such as salts, esters, polymers (e.g. pegylation), and/or solvates (including waters of hydration).	True	Isotretinoin (substance)	Inferred relationship	Some	1
Product containing precisely isotretinoin 20 milligram/1 each conventional release oral capsule (clinical drug)	The most specific description of a substance present in the manufactured dose form, before any dilution or transformation. It includes modifiers, such as salts, esters, polymers (e.g. pegylation), and/or solvates (including waters of hydration).	True	Isotretinoin (substance)	Inferred relationship	Some	1
Product containing precisely isotretinoin 40 milligram/1 each conventional release oral capsule (clinical drug)	The most specific description of a substance present in the manufactured dose form, before any dilution or transformation. It includes modifiers, such as salts, esters, polymers (e.g. pegylation), and/or solvates (including waters of hydration).	True	Isotretinoin (substance)	Inferred relationship	Some	1
Isotretinoin 30 mg oral capsule	The most specific description of a substance present in the manufactured dose form, before any dilution or transformation. It includes modifiers, such as salts, esters, polymers (e.g. pegylation), and/or solvates (including waters of hydration).	True	Isotretinoin (substance)	Inferred relationship	Some	1
Product containing precisely isotretinoin 500 microgram/1 gram conventional release cutaneous gel (clinical drug)	This attribute represents an ingredient that is the part of the active ingredient that the strength of a given product is based upon.	True	Isotretinoin (substance)	Inferred relationship	Some	1
Product containing precisely isotretinoin 500 microgram/1 gram conventional release cutaneous gel (clinical drug)	The most specific description of a substance present in the manufactured dose form, before any dilution or transformation. It includes modifiers, such as salts, esters, polymers (e.g. pegylation), and/or solvates (including waters of hydration).	True	Isotretinoin (substance)	Inferred relationship	Some	1
Product containing precisely erythromycin 20 milligram/1 gram and isotretinoin 500 microgram/1 gram conventional release cutaneous gel (clinical drug)	This attribute represents an ingredient that is the part of the active ingredient that the strength of a given product is based upon.	False	Isotretinoin (substance)	Inferred relationship	Some	1
Product containing precisely erythromycin 20 milligram/1 gram and isotretinoin 500 microgram/1 gram conventional release cutaneous gel (clinical drug)	The most specific description of a substance present in the manufactured dose form, before any dilution or transformation. It includes modifiers, such as salts, esters, polymers (e.g. pegylation), and/or solvates (including waters of hydration).	False	Isotretinoin (substance)	Inferred relationship	Some	1
Isotretinoin-containing product in cutaneous dose form	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	True	Isotretinoin (substance)	Inferred relationship	Some	1
Erythromycin- and isotretinoin-containing product in cutaneous dose form	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	True	Isotretinoin (substance)	Inferred relationship	Some	2
Erythromycin and isotretinoin only product	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	True	Isotretinoin (substance)	Inferred relationship	Some	2
Isotretinoin only product	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	True	Isotretinoin (substance)	Inferred relationship	Some	1
Product containing only isotretinoin in cutaneous dose form (medicinal product form)	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	True	Isotretinoin (substance)	Inferred relationship	Some	1
Isotretinoin only product in oral dose form	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	True	Isotretinoin (substance)	Inferred relationship	Some	1
Erythromycin and isotretinoin only product in cutaneous dose form	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	True	Isotretinoin (substance)	Inferred relationship	Some	2
Product containing precisely erythromycin 20 milligram/1 gram and isotretinoin 500 microgram/1 gram conventional release cutaneous gel (clinical drug)	This attribute represents an ingredient that is the part of the active ingredient that the strength of a given product is based upon.	True	Isotretinoin (substance)	Inferred relationship	Some	2
Product containing precisely erythromycin 20 milligram/1 gram and isotretinoin 500 microgram/1 gram conventional release cutaneous gel (clinical drug)	The most specific description of a substance present in the manufactured dose form, before any dilution or transformation. It includes modifiers, such as salts, esters, polymers (e.g. pegylation), and/or solvates (including waters of hydration).	True	Isotretinoin (substance)	Inferred relationship	Some	2
A rare teratogenic embryofetopathy due to exposure to isotretinoin, an oral synthetic vitamin A derivative, which is used to treat severe recalcitrant cystic acne. Exposure to isotretinoin during the first trimester of pregnancy has been associated with an increased risk of spontaneous abortions and severe birth defects including serious craniofacial (microcephaly, asymmetric crying facies, microphthalmia, developmental abnormalities of the external ear, ocular hypertelorism), cardiovascular (conotruncal heart defects, aortic arch abnormalities), and central nervous system (hydrocephalus, microcephaly, lissencephaly, Dandy-Walker malformation, cognitive deficit) anomalies and thymic aplasia.	Causative agent	True	Isotretinoin (substance)	Inferred relationship	Some	1

This concept is not in any reference sets

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Id	Description	Lang	Type	Status	Case?	Module
1461386011	Isotretinoin (substance)	en	Fully specified name	Active	Entire term case insensitive (core metadata concept)	SNOMED CT core
1481313017	Isotretinoin	en	Synonym (core metadata concept)	Active	Entire term case insensitive (core metadata concept)	SNOMED CT core
1491926011	13-cis-Retinoic acid	en	Synonym (core metadata concept)	Active	Only initial character case insensitive (core metadata concept)	SNOMED CT core
4498521000005114	Isotretinoin	da	Synonym (core metadata concept)	Active	Entire term case insensitive (core metadata concept)	Danish module (core metadata concept)