387172005: Fluorouracil (substance)

SNOMED CT Concept\Substance\...

\Substance categorized by disposition\Substance with effector mechanism of action (substance)\Enzyme inhibitor\Transferase inhibitor\Methyltransferase inhibitor\Thymidylate synthase inhibitor\Fluorouracil (substance)
\Substance categorized by disposition\Immunomodulator\Antimetabolite (substance)\Pyrimidine analog (substance)\Fluoropyrimidine (substance)\Fluorouracil (substance)

\A grouper concept for substances that are used in medicinal products for medical treatment, and also psychoactive substances that have few or no legitimate medical uses or that are not legally available to the person using them.\Immunologic agent (substance)\Pyrimidine analog (substance)\Fluoropyrimidine (substance)\Fluorouracil (substance)
\A grouper concept for substances that are used in medicinal products for medical treatment, and also psychoactive substances that have few or no legitimate medical uses or that are not legally available to the person using them.\Antineoplastic agent (substance)\Antimetabolite (substance)\Pyrimidine analog (substance)\Fluoropyrimidine (substance)\Fluorouracil (substance)

\Substance categorised by structure\Chemical\Chemical categorized by structure (substance)\...

\Nitrogen and/or nitrogen compound (substance)\Nitrogen compound\Organic nitrogen compound\Pyrimidine and/or pyrimidine derivative\Pyrimidine analog (substance)\Fluoropyrimidine (substance)\Fluorouracil (substance)

\Organic compound\Organic cyclic compound\Heterocyclic compound\Pyrimidine and/or pyrimidine derivative\Pyrimidine analog (substance)\Fluoropyrimidine (substance)\Fluorouracil (substance)
\Organic compound\Organic nitrogen compound\Pyrimidine and/or pyrimidine derivative\Pyrimidine analog (substance)\Fluoropyrimidine (substance)\Fluorouracil (substance)

Status: current, Not sufficiently defined by necessary conditions definition status (core metadata concept). Date: 31-Jan 2003. Module: SNOMED CT core

Descriptions:

Expanded Value Set

Outbound Relationships	Type	Target	Active	Characteristic	Refinability	Group	Values
Fluorouracil (substance)	Is a	Pyrimidine analog (substance)	false	Inferred relationship	Some
Fluorouracil (substance)	This attribute specifies the behavior that a substance will exhibit or participate in, given the appropriate context.	A substance that competes with, replaces or inhibits a specific metabolite of a cell and thereby interferes with the cell's normal metabolic functioning.	true	Inferred relationship	Some
Fluorouracil (substance)	Is a	Fluoropyrimidine (substance)	true	Inferred relationship	Some
Fluorouracil (substance)	Is a	Enzyme inhibitor	false	Inferred relationship	Some
Fluorouracil (substance)	Is a	Thymidylate synthase inhibitor	true	Inferred relationship	Some
Fluorouracil (substance)	This attribute specifies the behavior that a substance will exhibit or participate in, given the appropriate context.	Thymidylate synthase inhibitor (disposition)	true	Inferred relationship	Some

Inbound Relationships	Type	Active	Source	Characteristic	Refinability	Group
Fluorouracil measurement	Component	True	Fluorouracil (substance)	Inferred relationship	Some	1
Accidental fluorouracil poisoning	Causative agent	False	Fluorouracil (substance)	Inferred relationship	Some
Intentional fluorouracil poisoning	Causative agent	False	Fluorouracil (substance)	Inferred relationship	Some
forgiftning med fluoruracil, uvist med hvilken hensigt	Causative agent	False	Fluorouracil (substance)	Inferred relationship	Some	1
Fluorouracil adverse reaction	Causative agent	True	Fluorouracil (substance)	Inferred relationship	Some	1
Allergy to fluorouracil	Causative agent	False	Fluorouracil (substance)	Inferred relationship	Some
Fluorouracil overdose	Causative agent	True	Fluorouracil (substance)	Inferred relationship	Some	1
Accidental fluorouracil overdose	Causative agent	True	Fluorouracil (substance)	Inferred relationship	Some	1
Intentional fluorouracil overdose	Causative agent	True	Fluorouracil (substance)	Inferred relationship	Some	1
overdosis af fluoruracil, uvist med hvilken hensigt	Causative agent	False	Fluorouracil (substance)	Inferred relationship	Some	1
Product containing fluorouracil (medicinal product)	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	True	Fluorouracil (substance)	Inferred relationship	Some	1
Poisoning by fluorouracil	Causative agent	True	Fluorouracil (substance)	Inferred relationship	Some	1
Product containing precisely fluorouracil 50 milligram/1 gram conventional release cutaneous cream (clinical drug)	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Fluorouracil (substance)	Inferred relationship	Some
fluoruracil 25 mg/ml, opløsning til injektion, hætteglas a 100 ml	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Fluorouracil (substance)	Inferred relationship	Some
fluorouracil 50 mg/ml injektionsvæske, opløsning, hætteglas a 50 ml	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Fluorouracil (substance)	Inferred relationship	Some
fluoruracil 25 mg/ml, opløsning til injektion, hætteglas a 10 ml	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Fluorouracil (substance)	Inferred relationship	Some
Fluorouracil 250 mg oral capsule	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Fluorouracil (substance)	Inferred relationship	Some
fluoruracil 25 mg/ml, opløsning til injektion, hætteglas a 20 ml	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Fluorouracil (substance)	Inferred relationship	Some
fluoruracil 25 mg/ml, infusionsvæske, opløsning i flaske a 200 ml	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Fluorouracil (substance)	Inferred relationship	Some
fluoruracil 1 % opløsning	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Fluorouracil (substance)	Inferred relationship	Some
Product containing precisely fluorouracil 10 milligram/1 gram conventional release cutaneous cream (clinical drug)	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Fluorouracil (substance)	Inferred relationship	Some
Product containing precisely fluorouracil 5 milligram/1 gram conventional release cutaneous cream (clinical drug)	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Fluorouracil (substance)	Inferred relationship	Some
Fluorouracil 20 mg/mL cutaneous solution	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Fluorouracil (substance)	Inferred relationship	Some
fluorouracil 5 % opløsning	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Fluorouracil (substance)	Inferred relationship	Some
fluoruracil 50 mg opløsning til injektion, hætteglas a 100 ml	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Fluorouracil (substance)	Inferred relationship	Some
Fluorouracil 50mg injection solution 10mL vial	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Fluorouracil (substance)	Inferred relationship	Some
Product containing epinephrine and fluorouracil (medicinal product)	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	True	Fluorouracil (substance)	Inferred relationship	Some	1
fluoruracil 1 g/20 ml injektionsvæske	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Fluorouracil (substance)	Inferred relationship	Some
fluoruracil 500 mg/10 ml injektionsvæske	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Fluorouracil (substance)	Inferred relationship	Some
Trabeculectomy with intraoperative administration of fluorouracil (procedure)	Direct substance	True	Fluorouracil (substance)	Inferred relationship	Some	2
Accidental fluorouracil poisoning	Causative agent	True	Fluorouracil (substance)	Inferred relationship	Some	1
Intentional fluorouracil poisoning	Causative agent	True	Fluorouracil (substance)	Inferred relationship	Some	1
Fluorouracil (18-F) (substance)	Is a	False	Fluorouracil (substance)	Inferred relationship	Some
Fluorouracil sodium	Is a	False	Fluorouracil (substance)	Inferred relationship	Some
Trabeculectomy with intraoperative administration of fluorouracil (procedure)	Direct substance	False	Fluorouracil (substance)	Inferred relationship	Some	2
Allergy to fluorouracil	Causative agent	True	Fluorouracil (substance)	Inferred relationship	Some	1
Product containing fluorouracil in parenteral dose form (medicinal product form)	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	True	Fluorouracil (substance)	Inferred relationship	Some	1
Product containing fluorouracil in topical dosage form	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Fluorouracil (substance)	Inferred relationship	Some
Fluorouracil 250 mg oral capsule	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Fluorouracil (substance)	Inferred relationship	Some	1
Fluorouracil 250 mg oral capsule	This attribute represents an ingredient that is the part of the active ingredient that the strength of a given product is based upon.	True	Fluorouracil (substance)	Inferred relationship	Some	1
Fluorouracil sodium	This attribute indicates that the concept is a structural modification of another concept, and that the substance's intrinsic physicochemical properties remain unchanged.	True	Fluorouracil (substance)	Inferred relationship	Some
Fluorouracil (18-F) (substance)	This attribute indicates that the concept is a structural modification of another concept, and that the substance's intrinsic physicochemical properties remain unchanged.	True	Fluorouracil (substance)	Inferred relationship	Some
Fluorouracil 250 mg oral capsule	The most specific description of a substance present in the manufactured dose form, before any dilution or transformation. It includes modifiers, such as salts, esters, polymers (e.g. pegylation), and/or solvates (including waters of hydration).	True	Fluorouracil (substance)	Inferred relationship	Some	1
Product containing fluorouracil in oral dose form (medicinal product form)	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	True	Fluorouracil (substance)	Inferred relationship	Some	1
Product containing precisely fluorouracil 5 milligram/1 gram conventional release cutaneous cream (clinical drug)	This attribute represents an ingredient that is the part of the active ingredient that the strength of a given product is based upon.	True	Fluorouracil (substance)	Inferred relationship	Some	1
Product containing precisely fluorouracil 5 milligram/1 gram conventional release cutaneous cream (clinical drug)	The most specific description of a substance present in the manufactured dose form, before any dilution or transformation. It includes modifiers, such as salts, esters, polymers (e.g. pegylation), and/or solvates (including waters of hydration).	True	Fluorouracil (substance)	Inferred relationship	Some	1
Product containing precisely fluorouracil 10 milligram/1 gram conventional release cutaneous cream (clinical drug)	The most specific description of a substance present in the manufactured dose form, before any dilution or transformation. It includes modifiers, such as salts, esters, polymers (e.g. pegylation), and/or solvates (including waters of hydration).	True	Fluorouracil (substance)	Inferred relationship	Some	1
Product containing precisely fluorouracil 10 milligram/1 gram conventional release cutaneous cream (clinical drug)	This attribute represents an ingredient that is the part of the active ingredient that the strength of a given product is based upon.	True	Fluorouracil (substance)	Inferred relationship	Some	1
Product containing precisely fluorouracil 50 milligram/1 gram conventional release cutaneous cream (clinical drug)	The most specific description of a substance present in the manufactured dose form, before any dilution or transformation. It includes modifiers, such as salts, esters, polymers (e.g. pegylation), and/or solvates (including waters of hydration).	True	Fluorouracil (substance)	Inferred relationship	Some	1
Product containing precisely fluorouracil 50 milligram/1 gram conventional release cutaneous cream (clinical drug)	This attribute represents an ingredient that is the part of the active ingredient that the strength of a given product is based upon.	True	Fluorouracil (substance)	Inferred relationship	Some	1
Product containing precisely fluorouracil (as fluorouracil sodium) 2.5 gram/100 milliliter conventional release solution for injection vial	This attribute represents an ingredient that is the part of the active ingredient that the strength of a given product is based upon.	False	Fluorouracil (substance)	Inferred relationship	Some	1
Product containing precisely fluorouracil (as fluorouracil sodium) 250 milligram/10 milliliter conventional release solution for injection vial	This attribute represents an ingredient that is the part of the active ingredient that the strength of a given product is based upon.	False	Fluorouracil (substance)	Inferred relationship	Some	1
Product containing precisely fluorouracil (as fluorouracil sodium) 500 milligram/20 milliliter conventional release solution for injection vial	This attribute represents an ingredient that is the part of the active ingredient that the strength of a given product is based upon.	False	Fluorouracil (substance)	Inferred relationship	Some	1
Product containing precisely fluorouracil (as fluorouracil sodium) 500 milligram/10 milliliter conventional release solution for injection vial	This attribute represents an ingredient that is the part of the active ingredient that the strength of a given product is based upon.	False	Fluorouracil (substance)	Inferred relationship	Some	1
Product containing precisely fluorouracil (as fluorouracil sodium) 2.5 gram/50 milliliter conventional release solution for infusion vial	This attribute represents an ingredient that is the part of the active ingredient that the strength of a given product is based upon.	False	Fluorouracil (substance)	Inferred relationship	Some	1
Fluorouracil-containing product in cutaneous dose form	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	True	Fluorouracil (substance)	Inferred relationship	Some	1
Adrenaline and fluorouracil only product	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	True	Fluorouracil (substance)	Inferred relationship	Some	1
Product containing only fluorouracil (medicinal product)	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	True	Fluorouracil (substance)	Inferred relationship	Some	1
Fluorouracil only product in cutaneous dose form	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	True	Fluorouracil (substance)	Inferred relationship	Some	1
Product containing only fluorouracil in parenteral dose form (medicinal product form)	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	True	Fluorouracil (substance)	Inferred relationship	Some	1
Fluorouracil only product in oral dose form	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	True	Fluorouracil (substance)	Inferred relationship	Some	1
Fluorouracil (as fluorouracil sodium) 25 mg/mL solution for injection	This attribute represents an ingredient that is the part of the active ingredient that the strength of a given product is based upon.	True	Fluorouracil (substance)	Inferred relationship	Some	1
Fluorouracil (as fluorouracil sodium) 50 mg/mL solution for infusion	This attribute represents an ingredient that is the part of the active ingredient that the strength of a given product is based upon.	True	Fluorouracil (substance)	Inferred relationship	Some	1
Fluorouracil (as fluorouracil sodium) 50 mg/mL solution for injection	This attribute represents an ingredient that is the part of the active ingredient that the strength of a given product is based upon.	True	Fluorouracil (substance)	Inferred relationship	Some	1
Fluorouracil 20 mg/mL cutaneous solution	The most specific description of a substance present in the manufactured dose form, before any dilution or transformation. It includes modifiers, such as salts, esters, polymers (e.g. pegylation), and/or solvates (including waters of hydration).	True	Fluorouracil (substance)	Inferred relationship	Some	1
Fluorouracil 20 mg/mL cutaneous solution	This attribute represents an ingredient that is the part of the active ingredient that the strength of a given product is based upon.	True	Fluorouracil (substance)	Inferred relationship	Some	1
FOLFIRI antineoplastic chemotherapy regimen	Direct substance	True	Fluorouracil (substance)	Inferred relationship	Some	2
FOLFIRINOX antineoplastic chemotherapy regimen	Direct substance	True	Fluorouracil (substance)	Inferred relationship	Some	2
Product containing precisely fluorouracil (as fluorouracil sodium) 50 milligram/1 milliliter conventional release solution for infusion and/or injection (clinical drug)	This attribute represents an ingredient that is the part of the active ingredient that the strength of a given product is based upon.	True	Fluorouracil (substance)	Inferred relationship	Some	1
Fluorouracil (as fluorouracil sodium) 25 mg/mL solution for infusion and/or injection	This attribute represents an ingredient that is the part of the active ingredient that the strength of a given product is based upon.	True	Fluorouracil (substance)	Inferred relationship	Some	1
Product containing precisely fluorouracil 5 milligram/1 gram and salicylic acid 100 milligram/1 gram conventional release cutaneous solution (clinical drug)	The most specific description of a substance present in the manufactured dose form, before any dilution or transformation. It includes modifiers, such as salts, esters, polymers (e.g. pegylation), and/or solvates (including waters of hydration).	True	Fluorouracil (substance)	Inferred relationship	Some	1
Product containing precisely fluorouracil 5 milligram/1 gram and salicylic acid 100 milligram/1 gram conventional release cutaneous solution (clinical drug)	This attribute represents an ingredient that is the part of the active ingredient that the strength of a given product is based upon.	True	Fluorouracil (substance)	Inferred relationship	Some	1
Product containing only fluorouracil and salicylic acid (medicinal product)	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	True	Fluorouracil (substance)	Inferred relationship	Some	1
Product containing precisely fluorouracil 40 milligram/1 gram conventional release cutaneous cream (clinical drug)	The most specific description of a substance present in the manufactured dose form, before any dilution or transformation. It includes modifiers, such as salts, esters, polymers (e.g. pegylation), and/or solvates (including waters of hydration).	True	Fluorouracil (substance)	Inferred relationship	Some	1
Product containing precisely fluorouracil 40 milligram/1 gram conventional release cutaneous cream (clinical drug)	This attribute represents an ingredient that is the part of the active ingredient that the strength of a given product is based upon.	True	Fluorouracil (substance)	Inferred relationship	Some	1
Product containing only fluorouracil and salicylic acid in cutaneous dose form (medicinal product form)	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	True	Fluorouracil (substance)	Inferred relationship	Some	1
Subconjunctival administration of fluorouracil (procedure)	Direct substance	True	Fluorouracil (substance)	Inferred relationship	Some	1
Subconjunctival administration of fluorouracil to left eye (procedure)	Direct substance	True	Fluorouracil (substance)	Inferred relationship	Some	1
Subconjunctival administration of fluorouracil to right eye (procedure)	Direct substance	True	Fluorouracil (substance)	Inferred relationship	Some	1
Subconjunctival administration of fluorouracil to bilateral eyes (procedure)	Direct substance	True	Fluorouracil (substance)	Inferred relationship	Some	1
Subconjunctival administration of fluorouracil to bilateral eyes (procedure)	Direct substance	True	Fluorouracil (substance)	Inferred relationship	Some	2
Trabeculectomy of left eye with intraoperative administration of 5-fluorouracil	Direct substance	True	Fluorouracil (substance)	Inferred relationship	Some	2
Trabeculectomy of right eye with intraoperative administration of 5-fluorouracil	Direct substance	True	Fluorouracil (substance)	Inferred relationship	Some	2
Bilateral trabeculectomy with intraoperative administration of 5-fluorouracil	Direct substance	True	Fluorouracil (substance)	Inferred relationship	Some	3
Product containing fluorouracil and salicylic acid in cutaneous dose form (medicinal product form)	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	True	Fluorouracil (substance)	Inferred relationship	Some	1
Fluorouracil- and salicylic acid-containing product	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	True	Fluorouracil (substance)	Inferred relationship	Some	1

This concept is not in any reference sets

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Id	Description	Lang	Type	Status	Case?	Module
1461350010	Fluorouracil (substance)	en	Fully specified name	Active	Entire term case insensitive (core metadata concept)	SNOMED CT core
1481280012	Fluorouracil	en	Synonym (core metadata concept)	Active	Entire term case insensitive (core metadata concept)	SNOMED CT core
3721932017	5-fluorouracil	en	Synonym (core metadata concept)	Active	Entire term case insensitive (core metadata concept)	SNOMED CT core
4498291000005113	Fluorouracil	da	Synonym (core metadata concept)	Active	Entire term case insensitive (core metadata concept)	Danish module (core metadata concept)
4849821000005115	fluoruracil	da	Synonym (core metadata concept)	Active	Entire term case insensitive (core metadata concept)	Danish module (core metadata concept)