37411004: Tissue plasminogen activator (substance)

SNOMED CT Concept\Substance\...

\Substance categorized by disposition\Substance with effector mechanism of action (substance)\Enzyme activator\Tissue plasminogen activator
\Substance categorized by disposition\Enzyme\Hydrolase\Peptide hydrolase\Tissue plasminogen activator

\Substance categorised by structure\Chemical\Chemical categorized by structure (substance)\...

\Nitrogen and/or nitrogen compound (substance)\Nitrogen compound\Organic nitrogen compound\Amide and/or amide derivative (substance)\Substituted amide (substance)\Polypeptide\Protein\Tissue plasminogen activator

\Organic compound\Organic nitrogen compound\Amide and/or amide derivative (substance)\Substituted amide (substance)\Polypeptide\Protein\Tissue plasminogen activator

\Biological substance (substance)\Protein and/or protein derivative\Protein\Tissue plasminogen activator
\Biological substance (substance)\Polypeptide\Protein\Tissue plasminogen activator

Status: current, Not sufficiently defined by necessary conditions definition status (core metadata concept). Date: 31-Jan 2002. Module: SNOMED CT core

Descriptions:

Expanded Value Set

Outbound Relationships	Type	Target	Active	Characteristic	Refinability	Group	Values
Tissue plasminogen activator	Is a	Substance with plasminogen activator mechanism of action (substance)	false	Inferred relationship	Some
Tissue plasminogen activator	Is a	Hydrolase	false	Inferred relationship	Some
Tissue plasminogen activator	This attribute specifies the behavior that a substance will exhibit or participate in, given the appropriate context.	Hydrolase (disposition)	false	Inferred relationship	Some
Tissue plasminogen activator	This attribute specifies the behavior that a substance will exhibit or participate in, given the appropriate context.	Plasminogen activator (disposition)	true	Inferred relationship	Some
Tissue plasminogen activator	Is a	Enzyme activator	true	Inferred relationship	Some
Tissue plasminogen activator	Is a	Substance with protease mechanism of action	false	Inferred relationship	Some
Tissue plasminogen activator	Is a	Protein	true	Inferred relationship	Some
Tissue plasminogen activator	Is a	Peptide hydrolase	true	Inferred relationship	Some

Inbound Relationships	Type	Active	Source	Characteristic	Refinability	Group
tPA-PAI complex assay	Has measured component	False	Tissue plasminogen activator	Inferred relationship	Some
Tissue plasminogen activator assay	Has measured component	False	Tissue plasminogen activator	Inferred relationship	Some
Tissue plasminogen activator activity assay	Has measured component	False	Tissue plasminogen activator	Inferred relationship	Some
Tissue plasminogen activator antigen assay	Has measured component	False	Tissue plasminogen activator	Inferred relationship	Some
Tissue plasminogen activator antigen	Direct substance	False	Tissue plasminogen activator	Inferred relationship	Some
tPA-PAI complex assay	Component	False	Tissue plasminogen activator	Inferred relationship	Some	2
Tissue plasminogen activator assay	Component	True	Tissue plasminogen activator	Inferred relationship	Some	1
Tissue plasminogen activator activity assay	Component	True	Tissue plasminogen activator	Inferred relationship	Some	1
Tissue plasminogen activator antigen assay	Component	True	Tissue plasminogen activator	Inferred relationship	Some	1
Reteplase (substance)	Is a	False	Tissue plasminogen activator	Inferred relationship	Some
Alteplase (substance)	Is a	False	Tissue plasminogen activator	Inferred relationship	Some
Tenecteplase (substance)	Is a	False	Tissue plasminogen activator	Inferred relationship	Some
Product containing tissue plasminogen activator (medicinal product)	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	True	Tissue plasminogen activator	Inferred relationship	Some	1
Product containing reteplase (medicinal product)	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Tissue plasminogen activator	Inferred relationship	Some
alteplase 50 mg pulver og solvens til injektionsvæske, opløsning, hætteglas	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Tissue plasminogen activator	Inferred relationship	Some
alteplase 20 mg pulver og solvens til injektionsvæske, opløsning, hætteglas	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Tissue plasminogen activator	Inferred relationship	Some
alteplase 10 mg pulver og solvens til injektionsvæske, opløsning, hætteglas	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Tissue plasminogen activator	Inferred relationship	Some
reteplase 10 enheder pulver og solvens til injektionsvæske, opløsning, hætteglas	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Tissue plasminogen activator	Inferred relationship	Some
Product containing tenecteplase (medicinal product)	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Tissue plasminogen activator	Inferred relationship	Some
Product containing alteplase (medicinal product)	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Tissue plasminogen activator	Inferred relationship	Some
tenecteplase 8.000 IE (40 mg) pulver og solvens til injektionsvæske, opløsning, hætteglas	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Tissue plasminogen activator	Inferred relationship	Some
tenecteplase 10.000 IE (50 mg) injektionsvæske, opløsning, pulver og solvens i hætteglas	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Tissue plasminogen activator	Inferred relationship	Some
alteplase 1 mg injektionsvæske, opløsning, hætteglas a 1 ml	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Tissue plasminogen activator	Inferred relationship	Some
Reteplase, recombinant 10unt/vial powder	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Tissue plasminogen activator	Inferred relationship	Some
alteplase 100 mg pulver	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Tissue plasminogen activator	Inferred relationship	Some
Product containing only tissue plasminogen activator (medicinal product)	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	True	Tissue plasminogen activator	Inferred relationship	Some	1
Fibrinolytic disorder caused by tissue plasminogen activator	Causative agent	True	Tissue plasminogen activator	Inferred relationship	Some	2
Intravenous injection of tissue plasminogen activator (procedure)	Direct substance	True	Tissue plasminogen activator	Inferred relationship	Some	1
Intra-arterial injection of tissue plasminogen activator	Direct substance	True	Tissue plasminogen activator	Inferred relationship	Some	1
Adverse reaction caused by tissue plasminogen activator (disorder)	Causative agent	True	Tissue plasminogen activator	Inferred relationship	Some	1
tPA-PAI complex assay	Component	True	Tissue plasminogen activator	Inferred relationship	Some	1

Reference Sets

Description inactivation indicator reference set

GB English

US English

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Id	Description	Lang	Type	Status	Case?	Module
62404015	Tissue plasminogen activator	en	Synonym (core metadata concept)	Active	Entire term case insensitive (core metadata concept)	SNOMED CT core
62405019	T-PA	en	Synonym (core metadata concept)	Active	Entire term case sensitive (core metadata concept)	SNOMED CT core
769275011	Tissue plasminogen activator (substance)	en	Fully specified name	Active	Entire term case insensitive (core metadata concept)	SNOMED CT core
2692441000005113	Vævsplasminogenaktivator	da	Synonym (core metadata concept)	Active	Entire term case insensitive (core metadata concept)	Danish module (core metadata concept)