13331008: Atrophy (morphologic abnormality)

SNOMED CT Concept\Body structure\Body structure, altered from its original anatomical structure (morphologic abnormality)\Morphologically abnormal structure\Degenerative abnormality\Atrophy (morphologic abnormality)

Status: current, Not sufficiently defined by necessary conditions definition status (core metadata concept). Date: 31-Jan 2002. Module: SNOMED CT core

Descriptions:

Expanded Value Set

Outbound Relationships	Type	Target	Active	Characteristic	Refinability	Group	Values
Atrophy (morphologic abnormality)	Is a	Degenerative abnormality	false	Inferred relationship	Some
Atrophy (morphologic abnormality)	Is a	Degeneration	false	Inferred relationship	Some
Atrophy (morphologic abnormality)	Is a	Degenerative abnormality	true	Inferred relationship	Some

Inbound Relationships	Type	Active	Source	Characteristic	Refinability	Group
Cutaneous atrophy caused by corticosteroids	Associated morphology	True	Atrophy (morphologic abnormality)	Inferred relationship	Some	1
Atrophy of skin caused by drug (disorder)	Associated morphology	True	Atrophy (morphologic abnormality)	Inferred relationship	Some	1
Secondary anetoderma	Associated morphology	False	Atrophy (morphologic abnormality)	Inferred relationship	Some	1
Drug-induced cutis laxa (disorder)	Associated morphology	False	Atrophy (morphologic abnormality)	Inferred relationship	Some	2
Atrophy of gallbladder	Associated morphology	True	Atrophy (morphologic abnormality)	Inferred relationship	Some	1
Generalized iris atrophy (disorder)	Associated morphology	True	Atrophy (morphologic abnormality)	Inferred relationship	Some	1
Atrophic-hyperplastic gastritis	Associated morphology	True	Atrophy (morphologic abnormality)	Inferred relationship	Some	3
Roussy-Levy's syndrom	Associated morphology	False	Atrophy (morphologic abnormality)	Inferred relationship	Some	1
Atrophy of breast	Associated morphology	True	Atrophy (morphologic abnormality)	Inferred relationship	Some	1
Atrophy of corpus cavernosum	Associated morphology	True	Atrophy (morphologic abnormality)	Inferred relationship	Some	1
Stringhalt	Associated morphology	False	Atrophy (morphologic abnormality)	Inferred relationship	Some	1
Onychoatrophy due to lichen planus (disorder)	Associated morphology	False	Atrophy (morphologic abnormality)	Inferred relationship	Some	1
Atrophy of bile duct	Associated morphology	True	Atrophy (morphologic abnormality)	Inferred relationship	Some	1
Kronisk gul leveratrofi	Associated morphology	False	Atrophy (morphologic abnormality)	Inferred relationship	Some	1
Acne atrophica	Associated morphology	False	Atrophy (morphologic abnormality)	Inferred relationship	Some	2
lokaliseret hudatrofi på abdominalvæggen	Associated morphology	False	Atrophy (morphologic abnormality)	Inferred relationship	Some	1
A rare genetic endocrine disorder with characteristics of type 1 diabetes mellitus (DM), diabetes insipidus (DI), sensorineural deafness (D), bilateral optical atrophy (OA) and neurological signs. Two types of Wolfram syndrome may be distinguished: type 1 (WS1) and type 2 (WS2). Two causative genes have been identified: WFS1 (4p16.1) and CISD2 (4q24). The clinical criteria for Wolfram syndrome diagnosis are juvenile-onset diabetes mellitus and optic atrophy, family history of Wolfram syndrome or diabetes mellitus and deafness. Transmission is autosomal recessive.	Associated morphology	True	Atrophy (morphologic abnormality)	Inferred relationship	Some	1
Amyotrophy caused by herpes zoster	Associated morphology	True	Atrophy (morphologic abnormality)	Inferred relationship	Some	1
Muscle atrophy	Associated morphology	True	Atrophy (morphologic abnormality)	Inferred relationship	Some	1
Atrophic scarring of cheeks	Associated morphology	False	Atrophy (morphologic abnormality)	Inferred relationship	Some	1
Pancreatic acinar atrophy	Associated morphology	True	Atrophy (morphologic abnormality)	Inferred relationship	Some	1
Atrophy of pancreas	Associated morphology	True	Atrophy (morphologic abnormality)	Inferred relationship	Some	1
Atrophic thrush	Associated morphology	False	Atrophy (morphologic abnormality)	Inferred relationship	Some	1
Neuralgic amyotrophy	Associated morphology	False	Atrophy (morphologic abnormality)	Inferred relationship	Some	2
Roussy-Lévy syndrome	Associated morphology	False	Atrophy (morphologic abnormality)	Inferred relationship	Some	2
Neuralgic amyotrophy	Associated morphology	False	Atrophy (morphologic abnormality)	Inferred relationship	Some	3
Late cortical cerebellar atrophy	Associated morphology	False	Atrophy (morphologic abnormality)	Inferred relationship	Some	1
Atrophy of skeletal muscle of pelvis (disorder)	Associated morphology	False	Atrophy (morphologic abnormality)	Inferred relationship	Some	1
Atrophy of epithelium (morphologic abnormality)	Is a	True	Atrophy (morphologic abnormality)	Inferred relationship	Some
Glaucomatous atrophy of optic disc	Associated morphology	True	Atrophy (morphologic abnormality)	Inferred relationship	Some	1
Atrophy of skeletal muscle of pelvis (disorder)	Associated morphology	True	Atrophy (morphologic abnormality)	Inferred relationship	Some	1
An area of pseudoinfarction with congestion and parenchymal atrophy but no infarction	Is a	True	Atrophy (morphologic abnormality)	Inferred relationship	Some
Congenital cerebellar cortical atrophy (disorder)	Associated morphology	True	Atrophy (morphologic abnormality)	Inferred relationship	Some	2
Congenital atrophy of thyroid	Associated morphology	True	Atrophy (morphologic abnormality)	Inferred relationship	Some	2
Congenital renal atrophy	Associated morphology	True	Atrophy (morphologic abnormality)	Inferred relationship	Some	2
Congenital atrophy of left lobe of liver	Associated morphology	True	Atrophy (morphologic abnormality)	Inferred relationship	Some	2
Amyotrophia congenita	Associated morphology	False	Atrophy (morphologic abnormality)	Inferred relationship	Some	3
Congenital ischemic atrophy of central nervous system structure	Associated morphology	True	Atrophy (morphologic abnormality)	Inferred relationship	Some	3
Knobloch syndrome is defined by vitreoretinal and macular degeneration, and occipital encephalocele. The disease has characteristics of early-onset severe myopia (usually becoming apparent in the first year of life), vitreoretinal degeneration with retinal detachment, macular abnormalities, and midline encephalocele (mainly in the occipital region). The syndrome is clinically and genetically heterogeneous with three forms, KNO1, KNO2 and KNO3, being defined. KNO1 is caused by inactivating mutations in the collagen XVIII/endostatin gene (COL18A1) mapped to 21q22.3. The KNO2 form was defined when linkage to the KNO1 locus was excluded in a family reported from New Zealand. Recently, a novel type of KS (KNO3) was mapped to chromosome 17q11.2. Inherited as an autosomal recessive trait.	Associated morphology	True	Atrophy (morphologic abnormality)	Inferred relationship	Some	9
Localised lipoatrophy	Associated morphology	False	Atrophy (morphologic abnormality)	Inferred relationship	Some	2
Localized idiopathic lipoatrophy	Associated morphology	False	Atrophy (morphologic abnormality)	Inferred relationship	Some	2
Semicircular lipoatrophy	Associated morphology	False	Atrophy (morphologic abnormality)	Inferred relationship	Some	2
Lipodystrophia centrifugalis abdominalis infantalis	Associated morphology	False	Atrophy (morphologic abnormality)	Inferred relationship	Some	2
Post-inflammatory lipoatrophy	Associated morphology	False	Atrophy (morphologic abnormality)	Inferred relationship	Some	2
A rare localised lipodystrophy characterised by the appearance of asymptomatic, well-demarcated, variably sized, depressed, lipoatrophic lesions secondary to subcutaneous, intradermic or intramuscular drug injection, including corticosteroids, insulin, human growth hormone and antibiotics. Skin colouration may vary from white or hypopigmented to reddish, pinkish or violaceous. Epidermal atrophy may be also present.	Associated morphology	False	Atrophy (morphologic abnormality)	Inferred relationship	Some	2
Insulin lipoatrophy	Associated morphology	False	Atrophy (morphologic abnormality)	Inferred relationship	Some	2
Lipoatrophy (disorder)	Associated morphology	False	Atrophy (morphologic abnormality)	Inferred relationship	Some	1
Severe malnutrition due to type 2 diabetes mellitus	Associated morphology	False	Atrophy (morphologic abnormality)	Inferred relationship	Some	2
Acquired generalized lipodystrophy	Associated morphology	False	Atrophy (morphologic abnormality)	Inferred relationship	Some	2
Severe malnutrition due to type 1 diabetes mellitus (disorder)	Associated morphology	False	Atrophy (morphologic abnormality)	Inferred relationship	Some	2
Lipoatrophy due to Human immunodeficiency virus infection and treatment	Associated morphology	False	Atrophy (morphologic abnormality)	Inferred relationship	Some	2
Ozena laryngis	Associated morphology	True	Atrophy (morphologic abnormality)	Inferred relationship	Some	4
Amyotrophia congenita	Associated morphology	True	Atrophy (morphologic abnormality)	Inferred relationship	Some	2
Gyrate atrophy	Associated morphology	True	Atrophy (morphologic abnormality)	Inferred relationship	Some	3
Idiopathic atrophoderma of Pasini and Pierini	Associated morphology	True	Atrophy (morphologic abnormality)	Inferred relationship	Some	3
Lipoatrophy caused by antiretroviral drug	Associated morphology	False	Atrophy (morphologic abnormality)	Inferred relationship	Some	1
Atrophic endometritis	Associated morphology	True	Atrophy (morphologic abnormality)	Inferred relationship	Some	2
Choroideremia co-occurrent with hypopituitarism	Associated morphology	False	Atrophy (morphologic abnormality)	Inferred relationship	Some	3
Altered behavior due to Pick's disease (disorder)	Associated morphology	False	Atrophy (morphologic abnormality)	Inferred relationship	Some	4
Behr syndrome	Associated morphology	False	Atrophy (morphologic abnormality)	Inferred relationship	Some	1
A severe form of axonal Charcot-Marie-Tooth disease, a peripheral sensorimotor neuropathy, with onset in the 2nd or 3rd decade, characterized by ulcerations and infections of feet. Symmetric and distal weakness develops mostly in the legs together with a severe symmetric distal sensory loss, tendon reflexes are only reduced at ankles and foot deformities, including pes cavus or planus and hammer toes, appear in childhood.	Associated morphology	True	Atrophy (morphologic abnormality)	Inferred relationship	Some	2
A form of axonal Charcot-Marie-Tooth disease, a peripheral sensorimotor neuropathy, characterized by the association of vocal cord anomalies, impairment of respiratory muscles and sensorineural hearing loss with the distal hands and feet weakness. Onset is between infancy and the 6th decade.	Associated morphology	True	Atrophy (morphologic abnormality)	Inferred relationship	Some	2
A form of axonal Charcot-Marie-Tooth disease, a peripheral sensorimotor neuropathy, characterized by distal weakness primarily and predominantly occurring in the upper limbs and tendon reflexes absent or reduced in the arms and decreased in the legs. Progression is slow.	Associated morphology	True	Atrophy (morphologic abnormality)	Inferred relationship	Some	2
A form of axonal Charcot-Marie-Tooth disease, a peripheral sensorimotor neuropathy, with onset in the first to 6th decade with a gait anomaly and a leg weakness that reaches the arms secondarily. Tendon reflexes are reduced or absent and, after years, all patients have a pes cavus. Other signs may be present, including hearing loss and postural tremor.	Associated morphology	True	Atrophy (morphologic abnormality)	Inferred relationship	Some	2
A form of axonal Charcot-Marie-Tooth disease, a peripheral sensorimotor neuropathy, characterized by a late onset with severe sensory loss (paresthesia and hypoesthesia) associated with distal weakness, mainly of the legs, and absent or reduced deep tendon reflexes.	Associated morphology	True	Atrophy (morphologic abnormality)	Inferred relationship	Some	2
A form of axonal Charcot-Marie-Tooth disease, a peripheral sensorimotor neuropathy, characterized by a relatively late onset, pupillary abnormalities and deafness, in most patients, associated with distal weakness and muscle atrophy.	Associated morphology	True	Atrophy (morphologic abnormality)	Inferred relationship	Some	2
Autosomal dominant Charcot-Marie-Tooth disease type 2A1 (disorder)	Associated morphology	True	Atrophy (morphologic abnormality)	Inferred relationship	Some	2
An X-linked syndromic intellectual disability characterized by intellectual disability, subcortical cerebral atrophy, dental anomalies, patella luxation, lower back skin dimple, and dysmorphic facial features.	Associated morphology	False	Atrophy (morphologic abnormality)	Inferred relationship	Some	4
Atrophy of quadriceps femoris muscle (disorder)	Associated morphology	True	Atrophy (morphologic abnormality)	Inferred relationship	Some	1
Atrophy of trapezius muscle (disorder)	Associated morphology	True	Atrophy (morphologic abnormality)	Inferred relationship	Some	1
Atrophy of temporalis muscle (disorder)	Associated morphology	True	Atrophy (morphologic abnormality)	Inferred relationship	Some	1
Atrophy of pectoral muscle (disorder)	Associated morphology	True	Atrophy (morphologic abnormality)	Inferred relationship	Some	1
Atrophy of latissimus dorsi muscle (disorder)	Associated morphology	True	Atrophy (morphologic abnormality)	Inferred relationship	Some	1
Atrophy of interosseous muscle of hand (disorder)	Associated morphology	True	Atrophy (morphologic abnormality)	Inferred relationship	Some	1
Atrophy of gluteus maximus muscle (disorder)	Associated morphology	True	Atrophy (morphologic abnormality)	Inferred relationship	Some	1
Atrophy of gastrocnemius muscle (disorder)	Associated morphology	True	Atrophy (morphologic abnormality)	Inferred relationship	Some	1
Atrophy of deltoid muscle (disorder)	Associated morphology	True	Atrophy (morphologic abnormality)	Inferred relationship	Some	1
A form of axonal Charcot-Marie-Tooth disease, a peripheral sensorimotor neuropathy, characterized by symmetric weakness primarily occurring in the lower limbs (distal muscles in a majority of cases) and reaching the arms only after 5 to 10 years, occasional and predominantly distal sensory loss and reduced tendon reflexes. It presents with gait anomaly between the 1st and 6th decade and early onset is generally associated to a more severe phenotype which may include foot drop.	Associated morphology	True	Atrophy (morphologic abnormality)	Inferred relationship	Some	2
A form of axonal Charcot-Marie-Tooth disease, a peripheral sensorimotor neuropathy with onset associated to development of foot deformity and walking difficulties between the 1st and the 8th decades, with a median range in the 2nd one. Weakness and sensory loss involve primarily the legs and ankles tendon reflexes are reduced. This disorder has a slowly progressive course.	Associated morphology	True	Atrophy (morphologic abnormality)	Inferred relationship	Some	2
An axonal Charcot-Marie-Tooth (CMT) peripheral sensorimotor polyneuropathy.	Associated morphology	True	Atrophy (morphologic abnormality)	Inferred relationship	Some	2
A form of axonal Charcot-Marie-Tooth disease, a peripheral sensorimotor neuropathy. In the single family reported to date, CMT2L onset is between 15 and 33 years. Patients present with a symmetric distal weakness of legs and occasionally of the hands, absent or reduced tendon reflexes, distal legs sensory loss and frequently a pes cavus. Progression is slow.	Associated morphology	True	Atrophy (morphologic abnormality)	Inferred relationship	Some	2
A form of axonal Charcot-Marie-Tooth disease, a peripheral motor and sensory neuropathy, characterized by congenital ptosis and early cataract associated to a mildly progressive peripheral neuropathy of variable onset from birth to the 6th decade, pes cavus, reduced to absent ankles tendon reflexes and sometimes neutropenia.	Associated morphology	True	Atrophy (morphologic abnormality)	Inferred relationship	Some	2
A mild form of axonal Charcot-Marie-Tooth disease, a peripheral sensorimotor neuropathy, characterized by distal legs sensory loss and weakness that can be asymmetric. Tendon reflexes are reduced in the knees and absent in ankles. Progression is slow.	Associated morphology	True	Atrophy (morphologic abnormality)	Inferred relationship	Some	2
Charcot-Marie-Tooth disease, type 2B2 (CMT2B2, also referred to as CMT4C3) is an axonal CMT peripheral sensorimotor polyneuropathy that has been described in a large consanguineous Costa Rican family of Spanish ancestry.	Associated morphology	True	Atrophy (morphologic abnormality)	Inferred relationship	Some	2
A rare genetic neurodegenerative disorder characterized by congenital microphthalmia, sunken eyes, blindness, microcephaly, severe intellectual disability, progressive spasticity, and seizures. Psychomotor development is normal in the first 6-8 months of life and thereafter declines rapidly and continuously. Brain MRI reveals progressive and extensive degenerative changes, especially cortex, cerebellum, brainstem, and corpus callosum atrophy, with complete loss of cerebral white matter.	Associated morphology	True	Atrophy (morphologic abnormality)	Inferred relationship	Some	2
A rare genetic neurodegenerative disorder characterized by congenital microphthalmia, sunken eyes, blindness, microcephaly, severe intellectual disability, progressive spasticity, and seizures. Psychomotor development is normal in the first 6-8 months of life and thereafter declines rapidly and continuously. Brain MRI reveals progressive and extensive degenerative changes, especially cortex, cerebellum, brainstem, and corpus callosum atrophy, with complete loss of cerebral white matter.	Associated morphology	False	Atrophy (morphologic abnormality)	Inferred relationship	Some	3
A rare variant of cutaneous lichen planus characterized by both annular and atrophic LP features in the same lesion.	Associated morphology	True	Atrophy (morphologic abnormality)	Inferred relationship	Some	1
Charcot-Marie-Tooth disease, type 2H (CMT2H, also referred to as CMT4C2) is an axonal CMT peripheral sensorimotor polyneuropathy associated with pyramidal involvement.	Associated morphology	True	Atrophy (morphologic abnormality)	Inferred relationship	Some	2
Choroidal atrophy	Associated morphology	True	Atrophy (morphologic abnormality)	Inferred relationship	Some	1
A rare ectodermal dysplasia syndrome, characterized by the association of choroidal atrophy (sometimes regional), together with other ectodermal dysplasia features including fine and sparse hair, absent or decreased lashes and eyebrows, and possibly mild visual loss and dysplastic/thick/grooved nails.	Associated morphology	False	Atrophy (morphologic abnormality)	Inferred relationship	Some	5
Cerebral atrophy	Associated morphology	True	Atrophy (morphologic abnormality)	Inferred relationship	Some	1
Rombo syndrome is characterized by vermiculate atrophoderma, milia, hypotrichosis, trichoepitheliomas, peripheral vasodilation with cyanosis and basal cell carcinomas.	Associated morphology	True	Atrophy (morphologic abnormality)	Inferred relationship	Some	2
Phthisis bulbi of left eye (disorder)	Associated morphology	False	Atrophy (morphologic abnormality)	Inferred relationship	Some	2
Phthisis bulbi of right eye (disorder)	Associated morphology	False	Atrophy (morphologic abnormality)	Inferred relationship	Some	2
Intellectual disability-developmental delay-contractures syndrome, formerly known as Wieacker-Wolff syndrome, is a severe X-linked recessive neurodevelopmental disorder characterized by severe contractures and intellectual disability.	Associated morphology	False	Atrophy (morphologic abnormality)	Inferred relationship	Some	3
A rare, genetic, X-linked syndromic intellectual disability disorder characterized by severe intellectual disability, microcephaly, post-natal growth retardation, severe visual impairment or blindness (due to optic atrophy), severe hearing defect, spasticity, epileptic seizures, restricted large-joint movements and early death (in infancy or early childhood). Facial dysmorphic features (large dysplastic ears and short broad nose) are additionally observed. There have been no further descriptions in the literature since 1993.	Associated morphology	False	Atrophy (morphologic abnormality)	Inferred relationship	Some	5
Atrophy of soft tissue of orbit (disorder)	Associated morphology	True	Atrophy (morphologic abnormality)	Inferred relationship	Some	1
Congenital atrophy of optic nerve (disorder)	Associated morphology	True	Atrophy (morphologic abnormality)	Inferred relationship	Some	1
Post poliomyelitis syndrome	Associated morphology	True	Atrophy (morphologic abnormality)	Inferred relationship	Some	2
Chorioretinal atrophy	Associated morphology	True	Atrophy (morphologic abnormality)	Inferred relationship	Some	2
Chorioretinal atrophy	Associated morphology	True	Atrophy (morphologic abnormality)	Inferred relationship	Some	3

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Id	Description	Lang	Type	Status	Case?	Module
22797016	Atrophy	en	Synonym (core metadata concept)	Active	Entire term case insensitive (core metadata concept)	SNOMED CT core
737978016	Atrophy (morphologic abnormality)	en	Fully specified name	Active	Entire term case insensitive (core metadata concept)	SNOMED CT core
1220945019	Atrophic	en	Synonym (core metadata concept)	Active	Entire term case insensitive (core metadata concept)	SNOMED CT core
2611481000005110	atrofi	da	Synonym (core metadata concept)	Active	Entire term case insensitive (core metadata concept)	Danish module (core metadata concept)