128283000: Chronic nervous system disorder (disorder)

SNOMED CT Concept\Clinical finding (finding)\Disease\...

\Disorder of body system\Disorder of nervous system (disorder)\Chronic nervous system disorder

\Chronic disease\Chronic nervous system disorder

Status: current, Sufficiently defined by necessary conditions definition status (core metadata concept). Date: 31-Jan 2002. Module: SNOMED CT core

Descriptions:

Expanded Value Set

Outbound Relationships	Type	Target	Active	Characteristic	Refinability	Group	Values
Chronic nervous system disorder	Is a	Disorder of nervous system (disorder)	true	Inferred relationship	Some
Chronic nervous system disorder	Is a	Chronic disease	true	Inferred relationship	Some
Chronic nervous system disorder	Finding site	Structure of nervous system (body structure)	true	Inferred relationship	Some	1
Chronic nervous system disorder	Course	Chronic	false	Inferred relationship	Some
Chronic nervous system disorder	Clinical course	Chronic	true	Inferred relationship	Some	2

Inbound Relationships	Type	Active	Source	Characteristic	Refinability	Group
Chronic cerebral ischemia	Is a	False	Chronic nervous system disorder	Inferred relationship	Some
Chronic major depressive disorder, single episode	Is a	False	Chronic nervous system disorder	Inferred relationship	Some
Chronic anoxic encephalopathy	Is a	False	Chronic nervous system disorder	Inferred relationship	Some
Chronic meningitis	Is a	True	Chronic nervous system disorder	Inferred relationship	Some
Persistent vegetative state	Is a	False	Chronic nervous system disorder	Inferred relationship	Some
Chronic recurrent major depressive disorder	Is a	False	Chronic nervous system disorder	Inferred relationship	Some
Chronic progressive non-hereditary chorea	Is a	False	Chronic nervous system disorder	Inferred relationship	Some
kronisk progredierende epilepsia partialis continua	Is a	False	Chronic nervous system disorder	Inferred relationship	Some
Chronic bipolar I disorder, most recent episode depressed	Is a	False	Chronic nervous system disorder	Inferred relationship	Some
Chronic non-neuropathic Gaucher's disease	Is a	False	Chronic nervous system disorder	Inferred relationship	Some
Chronic motor tic disorder	Is a	True	Chronic nervous system disorder	Inferred relationship	Some
Chronic brain syndrome	Is a	True	Chronic nervous system disorder	Inferred relationship	Some
Pure autonomic failure	Is a	True	Chronic nervous system disorder	Inferred relationship	Some
Chronic progressive paraparesis	Is a	True	Chronic nervous system disorder	Inferred relationship	Some
Chronic paroxysmal hemicrania	Is a	False	Chronic nervous system disorder	Inferred relationship	Some
Chronic mixed headache syndrome	Is a	True	Chronic nervous system disorder	Inferred relationship	Some
Intermittently raised pressure hydrocephalus	Is a	False	Chronic nervous system disorder	Inferred relationship	Some
Recurrent major depression	Is a	False	Chronic nervous system disorder	Inferred relationship	Some
Cauda equina-betinget claudicatio intermittens	Is a	False	Chronic nervous system disorder	Inferred relationship	Some
Chronic depression	Is a	False	Chronic nervous system disorder	Inferred relationship	Some
Seasonal affective disorder	Is a	False	Chronic nervous system disorder	Inferred relationship	Some
Acute-on-chronic glaucoma	Is a	False	Chronic nervous system disorder	Inferred relationship	Some
Intermittent angle-closure glaucoma	Is a	False	Chronic nervous system disorder	Inferred relationship	Some
Idiopathic feline polioencephalomyelitis	Is a	False	Chronic nervous system disorder	Inferred relationship	Some
Chronic viral encephalitis	Is a	False	Chronic nervous system disorder	Inferred relationship	Some
Granulomatous amoebic encephalitis	Is a	False	Chronic nervous system disorder	Inferred relationship	Some
Proventrikulær dilatationssygdom	Is a	False	Chronic nervous system disorder	Inferred relationship	Some
Benign multirecurrent endothelioleukocytal meningitis	Is a	False	Chronic nervous system disorder	Inferred relationship	Some
Recurrent manic episodes	Is a	False	Chronic nervous system disorder	Inferred relationship	Some
Recurrent depression	Is a	False	Chronic nervous system disorder	Inferred relationship	Some
Chronic echovirus meningoencephalitis	Is a	False	Chronic nervous system disorder	Inferred relationship	Some
Granulomatøs meningoencefalit	Is a	False	Chronic nervous system disorder	Inferred relationship	Some
Hepatic coma due to chronic hepatitis B (disorder)	Is a	False	Chronic nervous system disorder	Inferred relationship	Some
Chronic organic mental disorder (disorder)	Is a	False	Chronic nervous system disorder	Inferred relationship	Some
Recurrent hypersomnia (disorder)	Is a	False	Chronic nervous system disorder	Inferred relationship	Some
Chronic intracranial subdural hematoma	Is a	True	Chronic nervous system disorder	Inferred relationship	Some
kronisk inflammatorisk demyeliniserende polyneurit	Is a	False	Chronic nervous system disorder	Inferred relationship	Some
Chronic inflammatory demyelinating polyradiculoneuropathy	Is a	True	Chronic nervous system disorder	Inferred relationship	Some
Chronic non-traumatic intracranial subdural hemorrhage (disorder)	Is a	True	Chronic nervous system disorder	Inferred relationship	Some
Chronic paraplegia (disorder)	Is a	True	Chronic nervous system disorder	Inferred relationship	Some
Chronic paralysis due to lesion of spinal cord	Is a	False	Chronic nervous system disorder	Inferred relationship	Some
Chronic central serous chorioretinopathy	Is a	True	Chronic nervous system disorder	Inferred relationship	Some
Paroxysmal dystonia	Is a	False	Chronic nervous system disorder	Inferred relationship	Some
Spinal claudicatio intermittens	Is a	False	Chronic nervous system disorder	Inferred relationship	Some
A rare multiple congenital anomalies syndrome characterized by cutaneous mastocytosis, microcephaly, microtia and/or hearing loss, hypotonia and skeletal anomalies (e.g. clinodactyly, camptodactyly, scoliosis). Additional common features are short stature, intellectual disability and difficulties. Facial dysmorphism may include upslanted palpebral fissures, highly arched palate and micrognathia. Rarely, seizures and asymmetrically small feet have been reported.	Is a	False	Chronic nervous system disorder	Inferred relationship	Some
Frequent episodic tension-type headache (disorder)	Is a	False	Chronic nervous system disorder	Inferred relationship	Some
Chronic venous infarction of spinal cord (disorder)	Is a	False	Chronic nervous system disorder	Inferred relationship	Some
Recurrent complex partial epilepsy	Is a	False	Chronic nervous system disorder	Inferred relationship	Some
Complex regional pain syndrome	Is a	True	Chronic nervous system disorder	Inferred relationship	Some
Chronic painful neuropathy due to diabetes mellitus (disorder)	Is a	True	Chronic nervous system disorder	Inferred relationship	Some
Chronic painful polyneuropathy following chemotherapy	Is a	False	Chronic nervous system disorder	Inferred relationship	Some
Chronic intractable migraine without aura (disorder)	Is a	False	Chronic nervous system disorder	Inferred relationship	Some
A rare neurologic disease characterized by unpredictable, transient and spontaneous unresponsiveness lasting from hours to days, with a frequency of three to seven attacks per year, in the absence of readily discernible toxic, metabolic or structural causes.	Is a	False	Chronic nervous system disorder	Inferred relationship	Some
Recurrent benign focal seizures of childhood	Is a	False	Chronic nervous system disorder	Inferred relationship	Some
Distal hereditary motor neuropathy type 1 is a rare neuromuscular disease characterized by slowly progressive lower limb muscular weakness and atrophy, without sensory impairment. Additional clinical features may include pes cavus, hammertoe and increased muscle tone.	Is a	False	Chronic nervous system disorder	Inferred relationship	Some
A rare slowly progressive genetic peripheral neuropathy with characteristics of distal atrophy and weakness affecting the upper limbs (with a predilection for the thenar eminence) and subsequently the lower limbs, associated with unilateral or bilateral vocal cord paresis leading to hoarse voice, breathing difficulties and facial weakness.	Is a	False	Chronic nervous system disorder	Inferred relationship	Some
A rare axonal hereditary motor and sensory neuropathy with characteristics of slowly progressive distal muscle weakness and atrophy with or without sensory loss resulting in difficulty in walking, foot drop and pes cavus, that may be associated with pyramidal signs (extensor plantar responses, mild increase in tone, brisk tendon reflexes), muscle cramps, pain and spasticity.	Is a	True	Chronic nervous system disorder	Inferred relationship	Some
A rare axonal hereditary motor and sensory neuropathy with characteristics of progressive axonal neuropathy with limb weakness and severe distal sensory loss in all limbs and acrodystrophic changes leading to painless non-healing ulcers, osteomyelitis, contractures and mutilating lesions with loss of terminal phalanges. One family with three affected siblings is described and there have been no further descriptions in the literature since 1999.	Is a	True	Chronic nervous system disorder	Inferred relationship	Some
Charcot-Marie-Tooth disease type 2B5	Is a	True	Chronic nervous system disorder	Inferred relationship	Some
A rare genetic neuromuscular disease characterized by proximal muscle weakness with an early involvement of foot and hand muscles following normal motor development in early childhood, a rapidly progressive disease course leading to generalized areflexic tetraplegia with contractures, severe scoliosis, hyperlordosis, and progressive respiratory insufficiency leading to assisted ventilation. Cranial nerve functions are normal and tongue wasting and fasciculations are absent. Milder phenotype with a moderate generalized weakness and slower disease progress was reported. There is evidence the disease is caused by homozygous mutation in the gene encoding pleckstrin homology domain-containing protein, family G member 5 (PLEKHG5) on chromosome 1p36.	Is a	False	Chronic nervous system disorder	Inferred relationship	Some
A rare autosomal recessive distal hereditary motor neuropathy with characteristics of slowly progressive muscular weakness, hypotonia and atrophy of the lower limbs, more pronounced distally, leading to paralysis, and loss of tendon reflexes. Additional features may include pes cavus and mild dysphonia. The upper limbs are relatively spared. There is evidence this disease is caused by homozygous mutation in the DNAJB2 gene on chromosome 2q35.	Is a	True	Chronic nervous system disorder	Inferred relationship	Some
A genetic neurodegenerative disease with normal early development followed by childhood onset optic atrophy with progressive vision loss and eventually blindness, followed by progressive neurological decline that typically includes cerebellar ataxia, nystagmus, dorsal column dysfunction (decreased vibration and position sense), spastic paraplegia and finally tetraparesis. There is evidence this disease is caused by homozygous or compound heterozygous mutation in the UCHL1 gene on chromosome 4p13.	Is a	True	Chronic nervous system disorder	Inferred relationship	Some
A rare subtype of autosomal recessive intermediate Charcot-Marie-Tooth (CMT) disease with characteristics of childhood to adulthood-onset of progressive, moderate to severe, predominantly distal, mostly lower limb muscle weakness and atrophy, foot deformities (including pes cavus and hammer toes), absent deep tendon reflexes and distal sensory loss associated with decreased motor and sensory nerve conduction velocities and features of both demyelinating and axonal neuropathy on sural nerve biopsy. Caused by homozygous or compound heterozygous mutation in the PLEKHG5 gene on chromosome 1p36.	Is a	True	Chronic nervous system disorder	Inferred relationship	Some
A rare subtype of autosomal dominant Charcot-Marie-Tooth disease type 2 with characteristics of adolescent to adulthood-onset of symmetrical, slowly progressive distal muscle weakness and atrophy (with a predominant weakness of the distal lower limbs) associated with reduced or absent deep tendon reflexes, pes cavus and mild to moderated deep sensory impairment. There is evidence this disease is caused by a heterozygous loss-of-function mutation in the DHTKD1 gene on chromosome 10p14.	Is a	True	Chronic nervous system disorder	Inferred relationship	Some
A rare genetic neurodegenerative disorder characterized by progressive psychomotor and cognitive regression (manifesting with gait ataxia, spasticity, loss of language, mild to severe intellectual disability, pyramidal and extrapyramidal signs and, frequently, development of tetraplegia or tetraparesis) associated with variable degrees of lipodystrophy, hepatomegaly, hypertriglyceridemia and muscular hypertrophy. Hyperactivity, tremor and development of seizures may also be associated. Caused by homozygous or compound heterozygous mutation in the BSCL2 gene on chromosome 11q13.	Is a	True	Chronic nervous system disorder	Inferred relationship	Some
A rare neurometabolic disease characterised by a childhood onset of progressive spastic ataxia associated with gait disturbances, hyperreflexia, extensor plantar responses and non-ketotic hyperglycinaemia typically revealed by biochemical analysis. Additional signs of upper extremity spasticity, dysarthria, learning difficulties, poor concentration, nystagmus, optic atrophy and reduced visual acuity may also be associated. There is evidence the disease is caused by homozygous or compound heterozygous mutation in the GLRX5 gene on chromosome 14q32.	Is a	True	Chronic nervous system disorder	Inferred relationship	Some
A rare genetic subtype of autosomal dominant Charcot-Marie-Tooth disease type 2 with characteristics of early childhood-onset of slowly progressive, predominantly distal, lower limb muscle weakness and atrophy, delayed motor development, variable sensory loss and pes cavus in the presence of normal or near-normal nerve conduction velocities. Additional variable features may include proximal muscle weakness, abnormal gait, arthrogryposis, scoliosis, cognitive impairment, and spasticity. Caused by heterozygous mutation in the DYNC1H1 gene on chromosome 14q32.	Is a	True	Chronic nervous system disorder	Inferred relationship	Some
A rare syndromic genetic deafness with characteristics of a combination of muscle weakness, chronic neuropathic and myopathic features, hoarseness and sensorineural hearing loss. A wide range of disease onset and severity has been reported even within the same family. There is evidence the disease is caused by heterozygous mutation in the MYH14 gene on chromosome 19q13.	Is a	True	Chronic nervous system disorder	Inferred relationship	Some
A rare genetic axonal hereditary motor and sensory neuropathy disorder with characteristics of adulthood-onset of slowly progressive, occasionally asymmetrical, distal muscle weakness and atrophy (predominantly in the lower limbs), pan-modal sensory loss, muscle cramping in extremities and/or trunk, pes cavus and absent or reduced deep tendon reflexes. Gait anomalies and variable autonomic disturbances, such as erectile dysfunction and urinary urgency, may be associated. The disease can be caused by homozygous or heterozygous mutation in the LRSAM1 gene on chromosome 9q33.	Is a	True	Chronic nervous system disorder	Inferred relationship	Some
Muscle-eye-brain disease, congenital muscular dystrophy	Is a	True	Chronic nervous system disorder	Inferred relationship	Some
A rare genetic motor neuron disease with characteristics of slowly progressive predominantly proximal muscular weakness and atrophy which typically manifests with muscle cramps, fasciculations, decreased/absent deep tendon reflexes, hand tremor and elevated serum creatine kinase at onset and later associates gait disturbances and impaired vibration sensation. There is evidence the disease is caused by heterozygous mutation in the CHCHD10 gene on chromosome 22q11.	Is a	False	Chronic nervous system disorder	Inferred relationship	Some
A rare genetic motor neuron disease with characteristics of late childhood or adolescent onset of slowly progressive severe distal limb muscle weakness and wasting, in association with pyramidal signs, normal sensation and absence of bulbar involvement. Leads to degeneration of motor neurons in the brain and spinal cord.	Is a	True	Chronic nervous system disorder	Inferred relationship	Some
A rare genetic motor neuron disease with characteristics of adult-onset of slowly progressive proximal muscular weakness with fasciculations, amyotrophy, cramps and absent/hypoactive reflexes without bulbar or pyramidal involvement. Caused by heterozygous mutation in the gene encoding vesicle-associated membrane protein-associated protein B (VAPB) on chromosome 20q13.	Is a	False	Chronic nervous system disorder	Inferred relationship	Some
A rare neurological disease with characteristics of a generally deep poorly localised persistent facial pain that does not present characteristics of a cranial neuralgia and which cannot be attributed to another disorder.	Is a	True	Chronic nervous system disorder	Inferred relationship	Some
A rare acquired motor neuron disease with characteristics of a slowly progressive unilateral ascending or descending hemiplegia, associated with unilateral or asymmetrical pyramidal signs and no sensory loss. It is a diagnosis of exclusion and controversy exists regarding whether the presence of bulbar symptoms, sphincter disturbances, fasciculations or cognitive manifestations are characteristics of the disease.	Is a	True	Chronic nervous system disorder	Inferred relationship	Some
A rare genetic non-dystrophic myopathy disease with characteristics of childhood-onset severe external ophthalmoplegia, typically without ptosis, associated with mild, very slowly progressive muscular weakness and atrophy, involving the facial, neck flexor and limb muscles. Muscle biopsy shows type 1 fiber uniformity, absent or abnormally small type 2A fibers, increased variability of fiber size, internalized nuclei and/or fatty infiltration.	Is a	False	Chronic nervous system disorder	Inferred relationship	Some
Progressive external ophthalmoplegia	Is a	True	Chronic nervous system disorder	Inferred relationship	Some
Chronic hiccup is a rare movement disorder characterized by involuntary spasmodic contractions of the inspiratory muscles synchronized with larynx closure lasting for more than 48 hours.	Is a	False	Chronic nervous system disorder	Inferred relationship	Some
Alexander disease	Is a	True	Chronic nervous system disorder	Inferred relationship	Some
A rare retinal dystrophy with characteristics of photophobia, progressive loss of visual acuity, nystagmus, visual field abnormalities, abnormal color vision, and psychophysical and electrophysiological evidence of abnormal cone function. Progressive cone dystrophy usually presents in childhood or early adult life, and patients tend to develop rod photoreceptor dysfunction in later life.	Is a	True	Chronic nervous system disorder	Inferred relationship	Some
Progressive muscular atrophy	Is a	True	Chronic nervous system disorder	Inferred relationship	Some
Progressive multiple sclerosis	Is a	False	Chronic nervous system disorder	Inferred relationship	Some
Benign monomelic amyotrophy	Is a	True	Chronic nervous system disorder	Inferred relationship	Some
Recurrent atlantoaxial subluxation with myelopathy	Is a	False	Chronic nervous system disorder	Inferred relationship	Some
A rare genetic cerebral small vessel disease characterized by amyloid deposition in the cerebral blood vessels leading to predominantly hemorrhagic strokes, focal neurological deficits, and progressive cognitive decline eventually leading to dementia.	Is a	True	Chronic nervous system disorder	Inferred relationship	Some
Acute relapsing multiple sclerosis	Is a	False	Chronic nervous system disorder	Inferred relationship	Some
Demyelination of central nervous system due to Behcet disease (disorder)	Is a	False	Chronic nervous system disorder	Inferred relationship	Some
Chronic fatigue syndrome	Is a	True	Chronic nervous system disorder	Inferred relationship	Some
Neuronal ceroid lipofuscinosis 8	Is a	True	Chronic nervous system disorder	Inferred relationship	Some
Chronic infectious disease of central nervous system	Is a	True	Chronic nervous system disorder	Inferred relationship	Some
A chronic neuropathic pain syndrome of the abdominal wall caused by entrapment of anterior cutaneous branches of 7 to 12th intercostal nerves along the lateral border of the anterior rectus abdominis fascia.	Is a	True	Chronic nervous system disorder	Inferred relationship	Some
A rare genetic disease characterized by mild intellectual deficit, congenital cataract, progressive sensorineural hearing impairment, ataxia, peripheral neuropathy, and short stature. There have been no further descriptions in the literature since 1991.	Is a	True	Chronic nervous system disorder	Inferred relationship	Some
Persistent neonatal myasthenia gravis	Is a	True	Chronic nervous system disorder	Inferred relationship	Some
A rare life-threatening neurometabolic disease with characteristics of a progressive neurodegenerative course, epilepsy, retinopathy and progressive cardiomyopathy.	Is a	True	Chronic nervous system disorder	Inferred relationship	Some
Spondylometaphyseal dysplasia-cone-rod dystrophy syndrome is characterized by the association of spondylometaphyseal dysplasia (marked by platyspondyly, shortening of the tubular bones and progressive metaphyseal irregularity and cupping), with postnatal growth retardation and progressive visual impairment due to cone-rod dystrophy. So far, it has been described in eight individuals. Transmission appears to be autosomal recessive.	Is a	True	Chronic nervous system disorder	Inferred relationship	Some
A rare inflammatory optic neuropathy characterized by severe and persistent pain followed by subacute visual loss, a relapsing-remitting course, and steroid-dependence. Involvement of both optic nerves is common and is usually sequential. Serum antibodies against aquaporin 4 are absent in most cases. Magnetic resonance imaging shows contrast enhancement of the acutely inflamed optic nerves.	Is a	False	Chronic nervous system disorder	Inferred relationship	Some
A rare autosomal dominant hereditary axonal motor and sensory neuropathy characterized by adult onset of slowly progressive distal muscle weakness and atrophy, sensory impairment, and hyporeflexia beginning in the lower limbs. Progressive gait disturbance may lead to loss of independent ambulation in some patients at a higher age.	Is a	True	Chronic nervous system disorder	Inferred relationship	Some
A rare autosomal dominant hereditary axonal motor and sensory neuropathy characterized by childhood onset of slowly progressive distal muscle weakness and atrophy primarily affecting the lower limbs, associated with sensory impairment and ataxia presenting with an unsteady, broad-based gait and frequent falls. Additional signs include decreased deep tendon reflexes and hand tremor.	Is a	True	Chronic nervous system disorder	Inferred relationship	Some
A rare genetic multiple congenital anomalies/dysmorphic syndrome characterized by moderate intellectual disability, dysmorphic facial features (such as prominent glabella, synophrys, and prognathism), generalized hirsutism, bilateral single palmar creases, and seizures. Additional reported manifestations include slowly progressive neurological deterioration with muscular weakness and impaired gait and balance, as well as hypogammaglobulinemia with specific absence of plasma and/or secretory IgA, among others. Brain imaging may show mild cerebellar atrophy and thin corpus callosum.	Is a	True	Chronic nervous system disorder	Inferred relationship	Some
A rare genetic disease characterized by onset of neurological deterioration in the first two years of life, progressing to severe intellectual disability, profound ataxia, mild dyskinesia, axial hypotonia, camptocormia, and oculomotor apraxia. Some patients also develop nephropathy with features of tubulointerstitial nephritis, hypertension, and a tendency for hyperkalemia.	Is a	True	Chronic nervous system disorder	Inferred relationship	Some
A neurodegenerative disease with characteristics of progressive muscular paralysis reflecting degeneration of motor neurons in the primary motor cortex, corticospinal tracts, brainstem and spinal cord. Associated with mutations in the superoxide dismutase-1 gene (SOD1) on chromosome 21q22.	Is a	True	Chronic nervous system disorder	Inferred relationship	Some

Page 1 of 2 End

Reference Sets

US English

Back to Start

Id	Description	Lang	Type	Status	Case?	Module
206548019	Chronic nervous system disease	en	Synonym (core metadata concept)	Active	Entire term case insensitive (core metadata concept)	SNOMED CT core
206549010	Chronic disorder of nervous system	en	Synonym (core metadata concept)	Active	Entire term case insensitive (core metadata concept)	SNOMED CT core
206550010	Chronic disease of nervous system	en	Synonym (core metadata concept)	Active	Entire term case insensitive (core metadata concept)	SNOMED CT core
206551014	Chronic nervous system disorder	en	Synonym (core metadata concept)	Active	Entire term case insensitive (core metadata concept)	SNOMED CT core
732259017	Chronic nervous system disorder (disorder)	en	Fully specified name	Active	Entire term case insensitive (core metadata concept)	SNOMED CT core
2580901000005111	Kronisk sygdom i nervesystemet	da	Synonym (core metadata concept)	Active	Entire term case insensitive (core metadata concept)	Danish module (core metadata concept)