112674009: Fibrosis (morphologic abnormality)

SNOMED CT Concept\Body structure\Body structure, altered from its original anatomical structure (morphologic abnormality)\Morphologically abnormal structure\Lesion (morphologic abnormality)\Fibrosis AND/OR repair abnormality (morphologic abnormality)\Fibrosis

Status: current, Not sufficiently defined by necessary conditions definition status (core metadata concept). Date: 31-Jan 2002. Module: SNOMED CT core

Descriptions:

Expanded Value Set

Outbound Relationships	Type	Target	Active	Characteristic	Refinability	Group	Values
Fibrosis	Is a	Fibrosis AND/OR repair abnormality (morphologic abnormality)	true	Inferred relationship	Some

Inbound Relationships	Type	Active	Source	Characteristic	Refinability	Group
A rare genetic renal disease with characteristics of slowly progressive chronic tubulointerstitial nephritis leading to end-stage renal disease before the age of 50 years. The disease manifests mild proteinuria, glucosuria and occasionally urinary sediment abnormalities. Mild extrarenal manifestations such as recurrent upper respiratory tract infections and abnormal liver function tests may be associated. Renal biopsy reveals severe chronic interstitial fibrosis and tubular changes as well as hallmark karyomegalic tubular epithelial cells which line the proximal and distal tubules and have enlarged hyperchromatic nuclei. Caused by homozygous or compound heterozygous mutation in the FAN1 gene on chromosome 15q.	Associated morphology	True	Fibrosis	Inferred relationship	Some	1
CRST syndrome	Associated morphology	True	Fibrosis	Inferred relationship	Some	4
Familial idiopathic pulmonary fibrosis (disorder)	Associated morphology	True	Fibrosis	Inferred relationship	Some	2
Acute exacerbation of idiopathic pulmonary fibrosis (disorder)	Associated morphology	True	Fibrosis	Inferred relationship	Some	1
Glomerular fibrosis (disorder)	Associated morphology	True	Fibrosis	Inferred relationship	Some	1
Renal fibrosis	Associated morphology	True	Fibrosis	Inferred relationship	Some	1
External iliac artery endofibrosis (disorder)	Associated morphology	True	Fibrosis	Inferred relationship	Some	1
Myofibrosis	Associated morphology	True	Fibrosis	Inferred relationship	Some	1
A painful restriction of joint motion caused by excessive scarring following injury or operative procedure.	Associated morphology	True	Fibrosis	Inferred relationship	Some	1
Arthrofibrosis of right shoulder	Associated morphology	True	Fibrosis	Inferred relationship	Some	1
Bilateral arthrofibrosis fibrosis of knees	Associated morphology	True	Fibrosis	Inferred relationship	Some	1
Bilateral arthrofibrosis fibrosis of knees	Associated morphology	True	Fibrosis	Inferred relationship	Some	2
Arthrofibrosis of right knee (disorder)	Associated morphology	True	Fibrosis	Inferred relationship	Some	1
Arthrofibrosis of left shoulder (disorder)	Associated morphology	True	Fibrosis	Inferred relationship	Some	1
Arthrofibrosis of left knee (disorder)	Associated morphology	True	Fibrosis	Inferred relationship	Some	1
Arthrofibrosis of left elbow	Associated morphology	True	Fibrosis	Inferred relationship	Some	1
Arthrofibrosis of right elbow	Associated morphology	True	Fibrosis	Inferred relationship	Some	1
Periportal fibrosis	Associated morphology	True	Fibrosis	Inferred relationship	Some	1
Bilateral adhesive otitis media of middle ears	Associated morphology	True	Fibrosis	Inferred relationship	Some	1
Bilateral adhesive otitis media of middle ears	Associated morphology	True	Fibrosis	Inferred relationship	Some	2
Interstitial pulmonary fibrosis due to inhalation of substance	Associated morphology	True	Fibrosis	Inferred relationship	Some	1
Interstitial pulmonary fibrosis due to inhalation of drug	Associated morphology	True	Fibrosis	Inferred relationship	Some	1
Female frozen pelvis	Associated morphology	True	Fibrosis	Inferred relationship	Some	1
Female frozen pelvis	Associated morphology	True	Fibrosis	Inferred relationship	Some	2
Anterior proliferative vitreoretinopathy	Associated morphology	True	Fibrosis	Inferred relationship	Some	3
Posterior proliferative vitreoretinopathy	Associated morphology	True	Fibrosis	Inferred relationship	Some	3
Constrictive pericarditis	Associated morphology	True	Fibrosis	Inferred relationship	Some	2
Constrictive pericarditis caused by virus (disorder)	Associated morphology	True	Fibrosis	Inferred relationship	Some	1
Proliferative vitreoretinopathy	Associated morphology	True	Fibrosis	Inferred relationship	Some	3
Fibrosis of liver caused by alcohol (disorder)	Associated morphology	True	Fibrosis	Inferred relationship	Some	1
Alcoholic fibrosis and sclerosis of liver	Associated morphology	True	Fibrosis	Inferred relationship	Some	1
Intraperitoneal fibrosis	Associated morphology	True	Fibrosis	Inferred relationship	Some	1
Clonorchiasis with biliary cirrhosis	Associated morphology	True	Fibrosis	Inferred relationship	Some	3
Pituitary fibrosis	Associated morphology	True	Fibrosis	Inferred relationship	Some	1
Endomyocardial fibrosis (disorder)	Associated morphology	True	Fibrosis	Inferred relationship	Some	1
Endomyocardial fibrosis (disorder)	Associated morphology	True	Fibrosis	Inferred relationship	Some	2
Pituitary fibrosis with midline fibrosis	Associated morphology	True	Fibrosis	Inferred relationship	Some	1
Restrictive cardiomyopathy with endomyocardial fibrosis (disorder)	Associated morphology	True	Fibrosis	Inferred relationship	Some	1
Restrictive cardiomyopathy with endomyocardial fibrosis (disorder)	Associated morphology	True	Fibrosis	Inferred relationship	Some	2
Primary endomyocardial fibrosis restrictive cardiomyopathy	Associated morphology	True	Fibrosis	Inferred relationship	Some	2
Tropical endomyocardial fibrosis is a restrictive cardiopathy, occurring almost exclusively in children and young adults in tropical and subtropical regions, characterized by endocardial fibrosis, affecting the apices and the inflow tract of the right or left ventricle (or both) and manifesting with a restrictive cardiomyopathy and atrioventricular regurgitation leading to severe pulmonary hypertension, very high systemic venous pressure and congestive cardiac failure. Suspected etiologies include helminth and protozoal infestation and malnutrition.	Associated morphology	True	Fibrosis	Inferred relationship	Some	1
Tropical endomyocardial fibrosis is a restrictive cardiopathy, occurring almost exclusively in children and young adults in tropical and subtropical regions, characterized by endocardial fibrosis, affecting the apices and the inflow tract of the right or left ventricle (or both) and manifesting with a restrictive cardiomyopathy and atrioventricular regurgitation leading to severe pulmonary hypertension, very high systemic venous pressure and congestive cardiac failure. Suspected etiologies include helminth and protozoal infestation and malnutrition.	Associated morphology	True	Fibrosis	Inferred relationship	Some	2
Primary endomyocardial fibrosis cardiomyopathy	Associated morphology	True	Fibrosis	Inferred relationship	Some	2
Macular subretinal fibrosis	Associated morphology	True	Fibrosis	Inferred relationship	Some	2
Internal prosthetic device causing fibrosis	Associated morphology	True	Fibrosis	Inferred relationship	Some	1
Restrictive strabismus due to orbital fibrosis (disorder)	Associated morphology	True	Fibrosis	Inferred relationship	Some	1
A rare ciliopathy characterized by the association of nephronophthisis and liver fibrosis. Renal manifestations include chronic renal failure, polyuria, polydipsia, anemia, as well as increased echogenicity on renal ultrasound and interstitial fibrosis and tubular dilation on biopsy. Hepatic involvement manifests as hepatosplenomegaly with extensive fibrosis, destruction of the bile ducts, and cholestasis. Mild psychomotor retardation and ocular symptoms, such as strabismus, nystagmus, retinal degeneration, and anisocoria, have been reported in some patients.	Associated morphology	True	Fibrosis	Inferred relationship	Some	1
Chronic rheumatoid nodular fibrosis	Associated morphology	False	Fibrosis	Inferred relationship	Some	1
Fibrosis of upper respiratory tract due to paracoccidioidomycosis (disorder)	Associated morphology	True	Fibrosis	Inferred relationship	Some	1
A rare idiopathic interstitial pneumonia characterized by prominent subpleural and parenchymal fibroelastosis and pleural fibrosis, predominantly involving the upper lobes. Signs and symptoms include non-productive cough, dyspnea, and recurrent respiratory infections. Pneumothorax is a frequently reported complication. Pulmonary function test reveals a restrictive pattern and reduced diffusing capacity. Computed tomography shows pleural thickening with signs of fibrosis (traction bronchiectasis, architectural distortion, and loss of volume), and reticulation.	Associated morphology	True	Fibrosis	Inferred relationship	Some	1
Perinatal pulmonary fibroplasia	Associated morphology	False	Fibrosis	Inferred relationship	Some	1
Fibrosis of lung due to pulmonary paracoccidioidomycosis (disorder)	Associated morphology	True	Fibrosis	Inferred relationship	Some	1
Perinatal pulmonary fibroplasia	Associated morphology	True	Fibrosis	Inferred relationship	Some	1
Pulmonary fibroplasia	Associated morphology	True	Fibrosis	Inferred relationship	Some	1
Fibrosis of liver due to metabolic dysfunction-associated steatotic liver (disorder)	Associated morphology	True	Fibrosis	Inferred relationship	Some	1
Arthrofibrosis of joint of left hand (disorder)	Associated morphology	True	Fibrosis	Inferred relationship	Some	1
Arthrofibrosis of joint of right hand	Associated morphology	True	Fibrosis	Inferred relationship	Some	1
Arthrofibrosis of joint of bilateral hands (disorder)	Associated morphology	True	Fibrosis	Inferred relationship	Some	1
Arthrofibrosis of joint of bilateral hands (disorder)	Associated morphology	True	Fibrosis	Inferred relationship	Some	2
Arthrofibrosis of joint of finger of left hand	Associated morphology	True	Fibrosis	Inferred relationship	Some	1
Arthrofibrosis of joint of finger of right hand	Associated morphology	True	Fibrosis	Inferred relationship	Some	1
Arthrofibrosis of joint of right wrist region	Associated morphology	True	Fibrosis	Inferred relationship	Some	1
Arthrofibrosis of joint of left wrist region	Associated morphology	True	Fibrosis	Inferred relationship	Some	1
Arthrofibrosis of joint of bilateral wrist regions (disorder)	Associated morphology	True	Fibrosis	Inferred relationship	Some	1
Arthrofibrosis of joint of bilateral wrist regions (disorder)	Associated morphology	True	Fibrosis	Inferred relationship	Some	2
Arthrofibrosis of joint of right ankle region	Associated morphology	True	Fibrosis	Inferred relationship	Some	1
Arthrofibrosis of joint of left ankle region (disorder)	Associated morphology	True	Fibrosis	Inferred relationship	Some	1
Arthrofibrosis of joint of bilateral ankle regions (disorder)	Associated morphology	True	Fibrosis	Inferred relationship	Some	1
Arthrofibrosis of joint of bilateral ankle regions (disorder)	Associated morphology	True	Fibrosis	Inferred relationship	Some	2
Effusive constrictive pericarditis	Associated morphology	True	Fibrosis	Inferred relationship	Some	1
Fibrosis of adrenal gland	Associated morphology	True	Fibrosis	Inferred relationship	Some	1
Fibrosis of conjunctiva (disorder)	Associated morphology	True	Fibrosis	Inferred relationship	Some	1
Desmoplasia	Is a	True	Fibrosis	Inferred relationship	Some
Arthrofibrosis of joint of ankle	Associated morphology	True	Fibrosis	Inferred relationship	Some	1
Arthrofibrosis of joint of hand	Associated morphology	True	Fibrosis	Inferred relationship	Some	1
Arthrofibrosis of joint of wrist region	Associated morphology	True	Fibrosis	Inferred relationship	Some	1
Arthrofibrosis of joint of elbow	Associated morphology	True	Fibrosis	Inferred relationship	Some	1
Arthrofibrosis of joint of knee	Associated morphology	True	Fibrosis	Inferred relationship	Some	1
Arthrofibrosis of joint of shoulder region	Associated morphology	True	Fibrosis	Inferred relationship	Some	1
A rare genetic hepatic disease characterized by multiple segmental cystic dilatations of both central and smaller peripheral bile ducts associated with congenital hepatic fibrosis. Age of symptom onset is variable, as is disease progression. Patients present recurrent cholangitis, hepatolithiasis, and cholecystolithiasis. Portal hypertension may appear later in the disease course, and the risk of developing cholangiocarcinoma is increased significantly. The syndrome is often associated with autosomal recessive polycystic kidney disease.	Associated morphology	True	Fibrosis	Inferred relationship	Some	1
Fibrosis of skin following cosmetic surgery (disorder)	Associated morphology	True	Fibrosis	Inferred relationship	Some	1
Thickening or cording of lymphatic tissues following axillary node biopsy or dissection.	Associated morphology	True	Fibrosis	Inferred relationship	Some	1
A rare otorhinolaryngologic disease characterized by an indolent submucosal mass of variable size and extent, most commonly arising in the anterior nasal cavity, involving the nasal septum and lateral nasal wall, and potentially extending into the adjacent sinuses. Occurrence in the larynx and lower respiratory tract or the orbit is rare. Histological examination shows concentric angiocentric stromal fibrosis (onionskin fibrosis) and prominent eosinophils. Increased numbers of IgG4-positive plasma cells in the lesion may also be observed, in addition to elevated serum IgG4. Patients typically present with long-standing obstructive symptoms.	Associated morphology	True	Fibrosis	Inferred relationship	Some	1
Fibrosis of urinary bladder neck	Associated morphology	True	Fibrosis	Inferred relationship	Some	1
Arthrofibrosis of joint of foot (disorder)	Associated morphology	True	Fibrosis	Inferred relationship	Some	1
Arthrofibrosis of joint of left foot	Associated morphology	True	Fibrosis	Inferred relationship	Some	1
Arthrofibrosis of joint of right foot	Associated morphology	True	Fibrosis	Inferred relationship	Some	1
Arthrofibrosis of joint of bilateral feet (disorder)	Associated morphology	True	Fibrosis	Inferred relationship	Some	1
Arthrofibrosis of joint of bilateral feet (disorder)	Associated morphology	True	Fibrosis	Inferred relationship	Some	2
Arthrofibrosis of joint of left hip (disorder)	Associated morphology	True	Fibrosis	Inferred relationship	Some	1
Arthrofibrosis of joint of right hip (disorder)	Associated morphology	True	Fibrosis	Inferred relationship	Some	1
Arthrofibrosis of bilateral hips	Associated morphology	True	Fibrosis	Inferred relationship	Some	1
Arthrofibrosis of bilateral hips	Associated morphology	True	Fibrosis	Inferred relationship	Some	2
Arthrofibrosis of joint of hip (disorder)	Associated morphology	True	Fibrosis	Inferred relationship	Some	1
Arthrofibrosis of joint of bilateral shoulder regions (disorder)	Associated morphology	True	Fibrosis	Inferred relationship	Some	1
Arthrofibrosis of joint of bilateral shoulder regions (disorder)	Associated morphology	True	Fibrosis	Inferred relationship	Some	2
Empyemectomy	Direct morphology	True	Fibrosis	Inferred relationship	Some	2
Extrapleural pneumonectomy with empyemectomy	Direct morphology	True	Fibrosis	Inferred relationship	Some	3
Empyemectomy with lobectomy	Direct morphology	True	Fibrosis	Inferred relationship	Some	2
A rare interstitial lung disease characterized by early-onset, severe, progressive lung disease manifesting by respiratory distress, neurological symptoms including axial hypotonia, developmental delay, irritability, dystonia, poor visual contact and seizures, and variable multisystemic involvement including malabsorption, progressive growth failure, recurrent infections, chronic hemolytic anemia and liver dysfunction. Kidney dysfunction, cardiac involvement including cardiomegaly and cardiac hypertrophy, decreased vision and strabismus have also been reported. Lung fibrosis may cause death in infancy from respiratory failure.	Associated morphology	True	Fibrosis	Inferred relationship	Some	2

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Id	Description	Lang	Type	Status	Case?	Module
183325015	Fibrosis	en	Synonym (core metadata concept)	Active	Entire term case insensitive (core metadata concept)	SNOMED CT core
188609016	Fibrous repair	en	Synonym (core metadata concept)	Active	Entire term case insensitive (core metadata concept)	SNOMED CT core
190411019	Fibrous thickening	en	Synonym (core metadata concept)	Active	Entire term case insensitive (core metadata concept)	SNOMED CT core
190412014	Fibroplasia	en	Synonym (core metadata concept)	Active	Entire term case insensitive (core metadata concept)	SNOMED CT core
199699016	Fibrous replacement	en	Synonym (core metadata concept)	Active	Entire term case insensitive (core metadata concept)	SNOMED CT core
642480010	Fibrosis (morphologic abnormality)	en	Fully specified name	Active	Entire term case insensitive (core metadata concept)	SNOMED CT core
2848791000005113	fibrose	da	Synonym (core metadata concept)	Active	Entire term case insensitive (core metadata concept)	Danish module (core metadata concept)