| Inbound Relationships | 
Type | 
Active | 
Source | 
Characteristic | 
Refinability | 
Group | 
| Viable tumour present in specimen | 
Interprets | 
True | 
Lesion observable | 
Inferred relationship | 
Some | 
 2 | 
| Radiologic opacity | 
Interprets | 
False | 
Lesion observable | 
Inferred relationship | 
Some | 
 3 | 
| FIGO CC stage IIIB | 
Interprets | 
False | 
Lesion observable | 
Inferred relationship | 
Some | 
 2 | 
| Anal canal TNM finding | 
Interprets | 
False | 
Lesion observable | 
Inferred relationship | 
Some | 
 2 | 
| Clark melanoma level finding | 
Interprets | 
True | 
Lesion observable | 
Inferred relationship | 
Some | 
 2 | 
| Tumour invades beyond pancreatic capsule to colon (endocrine pancreas) | 
Interprets | 
True | 
Lesion observable | 
Inferred relationship | 
Some | 
 2 | 
| Extent of stromal invasion by tumour cannot be assessed | 
Interprets | 
True | 
Lesion observable | 
Inferred relationship | 
Some | 
 3 | 
| pT3 (III): Tumour involves one or both fallopian tubes, with peritoneal implants outside the pelvis (TNM category and FIGO stage) (fallopian tube) | 
Interprets | 
False | 
Lesion observable | 
Inferred relationship | 
Some | 
 2 | 
| Intergroup rhabdomyosarcoma study postoperative clinical group IA: localised tumour, confined to site of origin, completely resected | 
Interprets | 
True | 
Lesion observable | 
Inferred relationship | 
Some | 
 2 | 
| pT3 category | 
Interprets | 
False | 
Lesion observable | 
Inferred relationship | 
Some | 
 2 | 
| Appendix with tumor involvement, with perforation not at tumor | 
Interprets | 
True | 
Lesion observable | 
Inferred relationship | 
Some | 
 2 | 
| FIGO VM stage IV | 
Interprets | 
False | 
Lesion observable | 
Inferred relationship | 
Some | 
 2 | 
| pT3a: Tumor invades optic nerve through the level of the lamina cribrosa but not to the line of resection (retinoblastoma) | 
Interprets | 
False | 
Lesion observable | 
Inferred relationship | 
Some | 
 2 | 
| T4: Lung tumour of any size that invades any of the following: mediastinum; heart; great vessels; trachea; esophagus; vertebral body; carina | 
Interprets | 
False | 
Lesion observable | 
Inferred relationship | 
Some | 
 2 | 
| pT1b (IB): Clinically visible lesion confined to the cervix or microscopic lesion greater than T1a2/IA2 (TNM category and FIGO stage) (uterine cervix) | 
Interprets | 
False | 
Lesion observable | 
Inferred relationship | 
Some | 
 2 | 
| T4: Urinary bladder tumour invades any of the following: prostate, uterus, vagina, pelvic wall abdominal wall | 
Interprets | 
False | 
Lesion observable | 
Inferred relationship | 
Some | 
 2 | 
| pTis: Carcinoma in situ, intraepithelial (colon/rectum) | 
Interprets | 
False | 
Lesion observable | 
Inferred relationship | 
Some | 
 2 | 
| Functional status of pancreatic endocrine tumour unknown | 
Interprets | 
True | 
Lesion observable | 
Inferred relationship | 
Some | 
 2 | 
| Node stage N1biv | 
Interprets | 
True | 
Lesion observable | 
Inferred relationship | 
Some | 
 2 | 
| pN1a: Metastasis to level VI (pretracheal, paratracheal, and prelaryngeal/Delphian lymph nodes) (thyroid) | 
Interprets | 
False | 
Lesion observable | 
Inferred relationship | 
Some | 
 2 | 
| pM1a: Metastasis to skin, subcutaneous tissues, or distant lymph nodes (melanoma of the skin) | 
Interprets | 
False | 
Lesion observable | 
Inferred relationship | 
Some | 
 2 | 
| T3c,d: Colon/rectum tumor invades >5 mm beyond the border of the muscularis propria | 
Interprets | 
False | 
Lesion observable | 
Inferred relationship | 
Some | 
 2 | 
| pT2c category | 
Interprets | 
False | 
Lesion observable | 
Inferred relationship | 
Some | 
 2 | 
| pN1b: Metastasis to unilateral, bilateral, or contralateral cervical or superior mediastinal lymph nodes (thyroid) | 
Interprets | 
False | 
Lesion observable | 
Inferred relationship | 
Some | 
 2 | 
| pT3 (III): Tumour extends to pelvic wall and/or involves lower third of vagina and/or causes hydronephrosis or non-functioning kidney (TNM category and FIGO stage) (uterine cervix) | 
Interprets | 
False | 
Lesion observable | 
Inferred relationship | 
Some | 
 2 | 
| pT1b (IB): Tumour invades less than one-half of the myometrium (TNM category and FIGO stage) (corpus uteri) | 
Interprets | 
False | 
Lesion observable | 
Inferred relationship | 
Some | 
 2 | 
| N2: Metastasis in more than one regional lymph node | 
Interprets | 
False | 
Lesion observable | 
Inferred relationship | 
Some | 
 2 | 
| M1b (IV): All other metastatic sites | 
Interprets | 
False | 
Lesion observable | 
Inferred relationship | 
Some | 
 2 | 
| pT4b: Extrathyroidal anaplastic carcinoma - surgically unresectable (anaplastic carcinoma) (thyroid) | 
Interprets | 
False | 
Lesion observable | 
Inferred relationship | 
Some | 
 2 | 
| Lymphoma finding | 
Interprets | 
True | 
Lesion observable | 
Inferred relationship | 
Some | 
 2 | 
| Lymphoma stage III | 
Interprets | 
True | 
Lesion observable | 
Inferred relationship | 
Some | 
 2 | 
| Tumour involvement of noncontiguous structures absent | 
Interprets | 
True | 
Lesion observable | 
Inferred relationship | 
Some | 
 2 | 
| pT1a: Tumor limited to one vocal cord (may involve anterior or posterior commissure) with normal mobility (larynx, glottis) | 
Interprets | 
False | 
Lesion observable | 
Inferred relationship | 
Some | 
 2 | 
| Primitive neuroectodermal tumour/Ewing's sarcoma TNM finding | 
Interprets | 
False | 
Lesion observable | 
Inferred relationship | 
Some | 
 2 | 
| Low grade lymphoma, stage 1 | 
Interprets | 
True | 
Lesion observable | 
Inferred relationship | 
Some | 
 2 | 
| pT1: Tumour limited to the testis and epididymis without vascular/lymphatic invasion; tumour may invade into the tunica albuginea but not the tunica vaginalis (testis) | 
Interprets | 
False | 
Lesion observable | 
Inferred relationship | 
Some | 
 2 | 
| pT1b (IB): Tumour confined to the vulva or vulva and perineum, 2 cm or less in greatest dimension, and with stromal invasion greater than 1 mm (TNM category and FIGO stage) (vulva) | 
Interprets | 
False | 
Lesion observable | 
Inferred relationship | 
Some | 
 2 | 
| pT2a: Tumour confluent with or extending into the ciliary body and/or choroid with melanomalytic glaucoma (iris) (uveal melanoma) | 
Interprets | 
False | 
Lesion observable | 
Inferred relationship | 
Some | 
 2 | 
| Regional lymph nodes cannot be assessed | 
Interprets | 
True | 
Lesion observable | 
Inferred relationship | 
Some | 
 2 | 
| pN2a category | 
Interprets | 
False | 
Lesion observable | 
Inferred relationship | 
Some | 
 2 | 
| pN0(mol-) category | 
Interprets | 
False | 
Lesion observable | 
Inferred relationship | 
Some | 
 2 | 
| N3a: > 6 cm in dimension | 
Interprets | 
False | 
Lesion observable | 
Inferred relationship | 
Some | 
 2 | 
| pT4a: Tumour directly invades other organs or structures (colon/rectum) | 
Interprets | 
False | 
Lesion observable | 
Inferred relationship | 
Some | 
  | 
| pT2: Tumour invades muscularis propria (colon/rectum) | 
Interprets | 
False | 
Lesion observable | 
Inferred relationship | 
Some | 
 2 | 
| Microcalcifications in non-neoplastic tissue present | 
Interprets | 
True | 
Lesion observable | 
Inferred relationship | 
Some | 
 2 | 
| Invasive tumour border | 
Interprets | 
True | 
Lesion observable | 
Inferred relationship | 
Some | 
 3 | 
| T3a: Renal tumour invades the adrenal gland or perinephric tissues but not beyond Gerota's fascia | 
Interprets | 
False | 
Lesion observable | 
Inferred relationship | 
Some | 
 2 | 
| Epithelial ovarian tumour, FIGO stage IC | 
Interprets | 
False | 
Lesion observable | 
Inferred relationship | 
Some | 
 2 | 
| pT1: Tumour invades lamina propria or submucosa (stomach) | 
Interprets | 
False | 
Lesion observable | 
Inferred relationship | 
Some | 
 2 | 
| T1a: Esophagus/stomach tumour invades lamina propria | 
Interprets | 
False | 
Lesion observable | 
Inferred relationship | 
Some | 
 2 | 
| Status of metastases in marker lymph node unknown | 
Interprets | 
True | 
Lesion observable | 
Inferred relationship | 
Some | 
 2 | 
| T2: Tumour confined within the prostate | 
Interprets | 
False | 
Lesion observable | 
Inferred relationship | 
Some | 
 2 | 
| FIGO CC stage I | 
Interprets | 
False | 
Lesion observable | 
Inferred relationship | 
Some | 
 2 | 
| Abnormal radiologic density, diffuse | 
Interprets | 
True | 
Lesion observable | 
Inferred relationship | 
Some | 
 2 | 
| pT3: Tumor invades through the muscularis propria into the subserosa or into non-peritonealized pericolic or perirectal tissues (colon/rectum) | 
Interprets | 
False | 
Lesion observable | 
Inferred relationship | 
Some | 
 2 | 
| pT3: Tumour more than 16 mm in greatest diameter and/or greater than 10 mm in maximum height (thickness) without extraocular extension (ciliary body and choroid) (uveal melanoma) | 
Interprets | 
False | 
Lesion observable | 
Inferred relationship | 
Some | 
 2 | 
| Lymphoma involves muscular wall AND/OR subserosa | 
Interprets | 
True | 
Lesion observable | 
Inferred relationship | 
Some | 
 2 | 
| Tumour infiltration by lymphocytes brisk | 
Interprets | 
True | 
Lesion observable | 
Inferred relationship | 
Some | 
 2 | 
| Clinical stage I D | 
Interprets | 
False | 
Lesion observable | 
Inferred relationship | 
Some | 
 2 | 
| pM0: No distant metastasis (breast) | 
Interprets | 
False | 
Lesion observable | 
Inferred relationship | 
Some | 
 2 | 
| Cancer diagnosis based on primary site histological evidence | 
Interprets | 
True | 
Lesion observable | 
Inferred relationship | 
Some | 
 2 | 
| Protruding tumour lesion | 
Interprets | 
True | 
Lesion observable | 
Inferred relationship | 
Some | 
 2 | 
| Clinical stage I E | 
Interprets | 
False | 
Lesion observable | 
Inferred relationship | 
Some | 
 2 | 
| Tumour invades endothoracic fascia | 
Interprets | 
True | 
Lesion observable | 
Inferred relationship | 
Some | 
 3 | 
| pT4b: Tumour invades deep extradermal structures (i.e. cartilage, skeletal muscle, or bone) greater than 6mm in thickness (carcinoma of skin excluding eyelid, vulva, penis, and melanomas) | 
Interprets | 
False | 
Lesion observable | 
Inferred relationship | 
Some | 
 3 | 
| N2a: Metastasis in a single ipsilateral lymph node, > 3 cm but < 6 cm in greatest dimension | 
Interprets | 
False | 
Lesion observable | 
Inferred relationship | 
Some | 
 2 | 
| Vagina TNM finding | 
Interprets | 
False | 
Lesion observable | 
Inferred relationship | 
Some | 
 2 | 
| Adrenal gland involved by metastasis from renal tumour | 
Interprets | 
True | 
Lesion observable | 
Inferred relationship | 
Some | 
 2 | 
| Tumour minimally invades choroid | 
Interprets | 
True | 
Lesion observable | 
Inferred relationship | 
Some | 
 3 | 
| pT4a: Tumour invades skin, mandible, ear canal, and/or facial nerve (major salivary glands) | 
Interprets | 
False | 
Lesion observable | 
Inferred relationship | 
Some | 
 2 | 
| Dukes stage C2 | 
Interprets | 
True | 
Lesion observable | 
Inferred relationship | 
Some | 
 2 | 
| pTis: Tumor invades muscularis mucosae (colon/rectum) | 
Interprets | 
False | 
Lesion observable | 
Inferred relationship | 
Some | 
 2 | 
| T4d: Inflammatory carcinoma (breast) | 
Interprets | 
False | 
Lesion observable | 
Inferred relationship | 
Some | 
 2 | 
| pT3c (IIIC): Tumour involves one or both fallopian tubes, with peritoneal metastasis outside the pelvis more than 2 cm in diameter (TNM category and FIGO stage) (fallopian tube) | 
Interprets | 
False | 
Lesion observable | 
Inferred relationship | 
Some | 
 2 | 
| pT1: Tumour 5 cm or less in greatest dimension (extraosseous primitive neuroectodermal tumour/Ewing's sarcoma) | 
Interprets | 
False | 
Lesion observable | 
Inferred relationship | 
Some | 
 2 | 
| pT1c category | 
Interprets | 
False | 
Lesion observable | 
Inferred relationship | 
Some | 
 2 | 
| pT1b: Tumour 2 cm or less in greatest dimension, limited to dermis and greater than 2 mm in thickness, but not more than 6 mm in thickness (carcinoma of skin excluding eyelid, vulva, penis, and melanomas) | 
Interprets | 
False | 
Lesion observable | 
Inferred relationship | 
Some | 
 3 | 
| Renal tumor extends beyond Gerota's fascia macroscopically | 
Interprets | 
True | 
Lesion observable | 
Inferred relationship | 
Some | 
 2 | 
| Stomach TNM finding | 
Interprets | 
False | 
Lesion observable | 
Inferred relationship | 
Some | 
 2 | 
| Intergroup rhabdomyosarcoma study postoperative clinical group IIC: Locally extensive tumour (spread to regional lymph nodes), gross total resection, but microscopic residual disease | 
Interprets | 
True | 
Lesion observable | 
Inferred relationship | 
Some | 
 2 | 
| N4 category | 
Interprets | 
True | 
Lesion observable | 
Inferred relationship | 
Some | 
 2 | 
| pM1a: Distant metastasis to lung (primitive neuroectodermal tumour/Ewing's sarcoma) | 
Interprets | 
False | 
Lesion observable | 
Inferred relationship | 
Some | 
 2 | 
| Tumour invades iris | 
Interprets | 
True | 
Lesion observable | 
Inferred relationship | 
Some | 
 2 | 
| Cancer diagnosis based on cytological evidence | 
Interprets | 
True | 
Lesion observable | 
Inferred relationship | 
Some | 
 2 | 
| Tumour invades optic nerve at lamina cribrosa | 
Interprets | 
True | 
Lesion observable | 
Inferred relationship | 
Some | 
 2 | 
| Tumour invades retina | 
Interprets | 
True | 
Lesion observable | 
Inferred relationship | 
Some | 
 2 | 
| Tumor invades sclera | 
Interprets | 
True | 
Lesion observable | 
Inferred relationship | 
Some | 
 2 | 
| International Federation of Gynecology and Obstetrics cervical cancer (FIGO CC) stage Ia | 
Interprets | 
False | 
Lesion observable | 
Inferred relationship | 
Some | 
 2 | 
| Rectum involved by direct extension of malignant neoplasm | 
Interprets | 
True | 
Lesion observable | 
Inferred relationship | 
Some | 
 2 | 
| Residual tumour stage R0 | 
Interprets | 
False | 
Lesion observable | 
Inferred relationship | 
Some | 
 2 | 
| T4: Lung tumour of any size with separate tumour nodule(s) in same lobe | 
Interprets | 
False | 
Lesion observable | 
Inferred relationship | 
Some | 
 2 | 
| pN2: Metastasis to ipsilateral mediastinal and/or subcarinal lymph nodes(s) (lung) | 
Interprets | 
False | 
Lesion observable | 
Inferred relationship | 
Some | 
 2 | 
| Recurrent tumour | 
Interprets | 
False | 
Lesion observable | 
Inferred relationship | 
Some | 
 3 | 
| Renal tumour limited to kidney macroscopically | 
Interprets | 
True | 
Lesion observable | 
Inferred relationship | 
Some | 
 2 | 
| Tumour size, invasive component, cannot be determined | 
Interprets | 
True | 
Lesion observable | 
Inferred relationship | 
Some | 
 2 | 
| Vascular invasion by tumour is indeterminate | 
Interprets | 
True | 
Lesion observable | 
Inferred relationship | 
Some | 
 3 | 
| pT1 (I): Cervical carcinoma confined to uterus (extension to corpus should be disregarded) (TNM category and FIGO stage) (uterine cervix) | 
Interprets | 
False | 
Lesion observable | 
Inferred relationship | 
Some | 
 2 | 
| N2: Metastasis to unilateral internal iliac and/or inguinal lymph node(s) | 
Interprets | 
False | 
Lesion observable | 
Inferred relationship | 
Some | 
 2 | 
| pT2b: Tumour more than 5 cm in greatest dimension, deep tumour (soft tissue) | 
Interprets | 
False | 
Lesion observable | 
Inferred relationship | 
Some | 
 2 | 
| pM1a category | 
Interprets | 
False | 
Lesion observable | 
Inferred relationship | 
Some | 
 2 | 
| T1a1 (IA1): Tumour of uterine cervix with stromal invasion < 3.0 mm in depth and horizontal spread < 7.0 mm | 
Interprets | 
False | 
Lesion observable | 
Inferred relationship | 
Some | 
 2 |