Inbound Relationships |
Type |
Active |
Source |
Characteristic |
Refinability |
Group |
T4 (IVA): Tumor of uterine cervix/vagina invades mucosa of bladder or rectum and/or extends beyond true pelvis |
Is a |
False |
pT4 category |
Inferred relationship |
Some |
|
T4 (IVA): Endometrial tumor invades bladder mucosa and/or bowel mucosa |
Is a |
False |
pT4 category |
Inferred relationship |
Some |
|
T4: Lip: Tumor invades adjacent structures (cortical bone, inferior alveolar nerve, floor of mouth, skin of face) |
Is a |
False |
pT4 category |
Inferred relationship |
Some |
|
T4: Oral Cavity: Tumor invades adjacent structures (cortical bone, deep (extrinsic) muscle of tongue, maxillary sinus, skin) |
Is a |
False |
pT4 category |
Inferred relationship |
Some |
|
T4: Aerodigestive tract tumor invades adjacent structures (pterygoid muscles, mandible, hard palate, deep muscle of tongue, larynx) |
Is a |
False |
pT4 category |
Inferred relationship |
Some |
|
T4: Aerodigestive tract tumor invades adjacent structures (thyroid/cricoid cartilage, carotid artery, soft tissues of neck, prevertebral fascia/muscles, thyroid and/or esophagus) |
Is a |
False |
pT4 category |
Inferred relationship |
Some |
|
T4: Aerodigestive tumor invades base of skull, seventh nerve, and/or exceeds 6 cm in greatest dimension |
Is a |
False |
pT4 category |
Inferred relationship |
Some |
|
T4: Aerodigestive tract tumor invades orbital contents beyond the floor or medial wall including apex and/or any of the following: cribriform plate, base of skull, nasopharynx, sphenoid sinus, frontal sinus |
Is a |
False |
pT4 category |
Inferred relationship |
Some |
|
T4: Tumor invades through cricoid or thyroid cartilage and/or extends into other tissues beyond the larynx (trachea, soft tissues of neck, thyroid, esophagus) |
Is a |
False |
pT4 category |
Inferred relationship |
Some |
|
T4: Tumor invades through thyroid cartilage and/or extends to other tissues beyond the larynx (trachea, soft tissues of neck, pharynx) |
Is a |
False |
pT4 category |
Inferred relationship |
Some |
|
T4: Tumor invades through thyroid cartilage, and/or extends into soft tissues of the neck, thyroid, and/or esophagus |
Is a |
False |
pT4 category |
Inferred relationship |
Some |
|
T4: Aerodigestive tract tumor with intracranial extension and/or involvement of cranial nerves, infratemporal fossa, hypopharynx or orbit |
Is a |
False |
pT4 category |
Inferred relationship |
Some |
|
T4: Aerodigestive tract tumor with intracranial extension, orbital extension including apex, involving sphenoid and/or frontal sinus and/or skin of nose |
Is a |
False |
pT4 category |
Inferred relationship |
Some |
|
T4: Lung tumor of any size that invades any of the following: mediastinum; heart; great vessels; trachea; esophagus; vertebral body; carina |
Is a |
False |
pT4 category |
Inferred relationship |
Some |
|
T4: Lung tumor of any size with a malignant pleural effusion |
Is a |
False |
pT4 category |
Inferred relationship |
Some |
|
T4: Lung tumor of any size with separate tumor nodule(s) in same lobe |
Is a |
False |
pT4 category |
Inferred relationship |
Some |
|
T4: Renal tumor invades beyond Gerota's fascia |
Is a |
False |
pT4 category |
Inferred relationship |
Some |
|
T4: Breast tumor of any size with direct extension to chest wall or skin |
Is a |
False |
pT4 category |
Inferred relationship |
Some |
|
T4a: Breast tumor with extension to chest wall |
Is a |
False |
pT4 category |
Inferred relationship |
Some |
|
T4b: Edema (including peau d'orange) or ulceration of the skin of the breast or satellite skin nodules confined to the same breast |
Is a |
False |
pT4 category |
Inferred relationship |
Some |
|
T4c: Breast tumor, both T4a and T4b |
Is a |
False |
pT4 category |
Inferred relationship |
Some |
|
T4d: Inflammatory carcinoma (breast) |
Is a |
False |
pT4 category |
Inferred relationship |
Some |
|
T4: Tumor directly invades adjacent structures |
Is a |
False |
pT4 category |
Inferred relationship |
Some |
|
T4a: Colon/rectum tumor directly invades other organs or structures |
Is a |
False |
pT4 category |
Inferred relationship |
Some |
|
T4b: Colon/rectum tumor penetrates the visceral peritoneum |
Is a |
False |
pT4 category |
Inferred relationship |
Some |
|
T4: Ampulla tumor invades >2 cm into pancreas and/or into other adjacent organs |
Is a |
False |
pT4 category |
Inferred relationship |
Some |
|
T4: Pancreas tumor extends directly to any of the following: stomach; spleen; colon; adjacent large vessels |
Is a |
False |
pT4 category |
Inferred relationship |
Some |
|
T4: Urinary bladder tumor invades any of the following: prostate, uterus, vagina, pelvic wall abdominal wall |
Is a |
False |
pT4 category |
Inferred relationship |
Some |
|
T4: Renal pelvis/ureter tumor invades adjacent organs, or through the kidney into the perinephric fat |
Is a |
False |
pT4 category |
Inferred relationship |
Some |
|
T4a: Bladder tumor invades prostate or uterus or vagina |
Is a |
False |
pT4 category |
Inferred relationship |
Some |
|
T4b: Bladder tumor invades pelvic wall or abdominal wall |
Is a |
False |
pT4 category |
Inferred relationship |
Some |
|
T4: Testicular tumor invades scrotum with or without vascular/lymphatic invasion |
Is a |
False |
pT4 category |
Inferred relationship |
Some |
|
T4: Pleural tumor directly extends to any of the following: contralateral pleura, contralateral lung, peritoneum, intra-abdominal organs, cervical tissues |
Is a |
False |
pT4 category |
Inferred relationship |
Some |
|
T4: Thyroid tumor of any size extending beyond the thyroid capsule |
Is a |
False |
pT4 category |
Inferred relationship |
Some |
|
pT4: Tumor of any size with direct extension to chest wall or skin (breast) |
Is a |
False |
pT4 category |
Inferred relationship |
Some |
|
pT4a: Tumor directly invades other organs or structures (colon/rectum) |
Is a |
False |
pT4 category |
Inferred relationship |
Some |
|
pT4b: Tumor penetrates visceral peritoneum (colon/rectum) |
Is a |
False |
pT4 category |
Inferred relationship |
Some |
|
pT4: Tumor of lung as per American Joint Committee on Cancer 6th Edition definition (lung) |
Is a |
False |
pT4 category |
Inferred relationship |
Some |
|
pT4: Invasion of bladder AND/OR rectum (prostate) |
Is a |
False |
pT4 category |
Inferred relationship |
Some |
|
pT4: Tumor of any size invades adjacent organ(s), e.g., vagina, urethra, bladder (anal canal) |
Is a |
False |
pT4 category |
Inferred relationship |
Some |
|
pT4: Tumor directly invades other organs or structures and/or perforates visceral peritoneum (colon/rectum) |
Is a |
False |
pT4 category |
Inferred relationship |
Some |
|
pT4: Tumor invades beyond Gerota's fascia (kidney) |
Is a |
False |
pT4 category |
Inferred relationship |
Some |
|
pT4: Tumor invades peripancreatic soft tissues or other adjacent organs or structures (ampulla of Vater) |
Is a |
False |
pT4 category |
Inferred relationship |
Some |
|
pT4: Tumor(s) with direct invasion of adjacent organs other than the gallbladder or with perforation of visceral peritoneum (liver, including intrahepatic bile ducts) |
Is a |
False |
pT4 category |
Inferred relationship |
Some |
|
pT4 (IVA): Tumor invades mucosa of bladder or rectum and/or extends beyond true pelvis (bullous edema is not sufficient evidence to classify a tumor as pT4) (TNM category and FIGO stage) (uterine cervix) |
Is a |
False |
pT4 category |
Inferred relationship |
Some |
|
pT4 (IVA): Tumor invades bladder mucosa and/or bowel mucosa (TNM category and FIGO stage) (corpus uteri) |
Is a |
False |
pT4 category |
Inferred relationship |
Some |
|
pT4: Melanoma greater than 4.0 mm in thickness, with or without ulceration (melanoma of the skin) |
Is a |
False |
pT4 category |
Inferred relationship |
Some |
|
pT4: Tumor invades deep extradermal structures (i.e. cartilage, skeletal muscle, or bone) (carcinoma of skin excluding eyelid, vulva, penis, and melanomas) |
Is a |
False |
pT4 category |
Inferred relationship |
Some |
|
pT4a: Tumor invades the larynx, deep/extrinsic muscle of tongue, medial pterygoid muscle, hard palate, or mandible (oropharynx) |
Is a |
False |
pT4 category |
Inferred relationship |
Some |
|
pT4b: Tumor invades lateral pterygoid muscle, pterygoid plates, lateral nasopharynx, or skull base or encases carotid artery (oropharynx) |
Is a |
False |
pT4 category |
Inferred relationship |
Some |
|
pT4a: Tumor invades through cortical bone, inferior alveolar nerve, floor of mouth, or skin of face, i.e., chin or nose (lip) |
Is a |
False |
pT4 category |
Inferred relationship |
Some |
|
pT4a: Tumor invades through cortical bone, into deep (extrinsic) muscle of tongue (genioglossus, hyoglossus, palatoglossus, and styloglossus), maxillary sinus, or skin of face (oral cavity) |
Is a |
False |
pT4 category |
Inferred relationship |
Some |
|
pT4b: Tumor involves masticator space, pterygoid plates, or skull base and/or encases internal carotid artery (lip and oral cavity) |
Is a |
False |
pT4 category |
Inferred relationship |
Some |
|
pT4: Tumor with intracranial extension, and/or involvement of cranial nerves, infratemporal fossa, hypopharynx, orbit, or masticator space (nasopharynx) |
Is a |
False |
pT4 category |
Inferred relationship |
Some |
|
pT4a: Tumor invades thyroid/cricoid cartilage, hyoid bone, thyroid gland, esophagus or central compartment of soft tissue (hypopharynx) |
Is a |
False |
pT4 category |
Inferred relationship |
Some |
|
pT4b: Tumor invades prevertebral fascia, encases carotid artery, or involves mediastinal structures (hypopharynx) |
Is a |
False |
pT4 category |
Inferred relationship |
Some |
|
pT4a: Tumor invades through the thyroid cartilage and/or invades tissues beyond the larynx (e.g., trachea, soft tissues of the neck including deep extrinsic muscle of the tongue, strap muscles, thyroid, or esophagus) (larynx, supraglottis) |
Is a |
False |
pT4 category |
Inferred relationship |
Some |
|
pT4b: Tumor invades prevertebral space, encases carotid artery, or invades mediastinal structures (larynx, supraglottis) |
Is a |
False |
pT4 category |
Inferred relationship |
Some |
|
pT4a: Tumor invades through thyroid cartilage and/or invades tissues beyond the larynx (e.g., trachea, soft tissues of the neck including deep intrinsic muscle of the tongue, strap muscles, thyroid, or esophagus) (larynx, glottis) |
Is a |
False |
pT4 category |
Inferred relationship |
Some |
|
pT4b: Tumor invades prevertebral space, encases carotid artery, or invades mediastinal structures (larynx, glottis) |
Is a |
False |
pT4 category |
Inferred relationship |
Some |
|
pT4a: Tumor invades cricoid or thyroid cartilage and/or invades tissues beyond the larynx (e.g., trachea, soft tissues of the neck including deep extrinsic muscle of the tongue, strap muscles, thyroid, or esophagus) (larynx, subglottis) |
Is a |
False |
pT4 category |
Inferred relationship |
Some |
|
pT4b: Tumor invades prevertebral space, encases carotid artery, or invades mediastinal structures (larynx, subglottis) |
Is a |
False |
pT4 category |
Inferred relationship |
Some |
|
pT4a: Tumor invades anterior orbital contents, skin of cheek, pterygoid plates, infratemporal fossa, cribriform plate, sphenoid or frontal sinuses (maxillary sinus) |
Is a |
False |
pT4 category |
Inferred relationship |
Some |
|
pT4b: Tumor invades any of the following: orbital apex, dura, brain, middle cranial fossa, cranial nerves other than maxillary division of trigeminal nerve, nasopharynx, or clivus (maxillary sinus) |
Is a |
False |
pT4 category |
Inferred relationship |
Some |
|
pT4a: Tumor invades any of the following: anterior orbital contents, skin of nose or cheek, minimal extension to anterior cranial fossa, pterygoid plates, sphenoid or frontal sinuses (nasal cavity and ethmoid sinus) |
Is a |
False |
pT4 category |
Inferred relationship |
Some |
|
pT4b: Tumor invades any of the following: orbital apex, dura, brain, middle cranial fossa, cranial nerves other than maxillary division of trigeminal nerve, nasopharynx, or clivus (nasal cavity and ethmoid sinus) |
Is a |
False |
pT4 category |
Inferred relationship |
Some |
|
pT4a: Tumor invades skin, mandible, ear canal, and/or facial nerve (major salivary glands) |
Is a |
False |
pT4 category |
Inferred relationship |
Some |
|
pT4b: Tumor invades skull base and/or pterygoid plates and/or encases carotid artery (major salivary glands) |
Is a |
False |
pT4 category |
Inferred relationship |
Some |
|
pT4: Tumor invades any of the following: prostate, uterus, vagina, pelvic wall, abdominal wall (urinary bladder) |
Is a |
False |
pT4 category |
Inferred relationship |
Some |
|
pT4: Tumor invades adjacent organs, or through the kidney into the perinephric fat (renal pelvis and ureter) |
Is a |
False |
pT4 category |
Inferred relationship |
Some |
|
pT4: Tumor invades the scrotum with or without vascular/lymphatic invasion (testis) |
Is a |
False |
pT4 category |
Inferred relationship |
Some |
|
pT4: Tumor involves the celiac axis or the superior mesenteric artery (exocrine pancreas) |
Is a |
False |
pT4 category |
Inferred relationship |
Some |
|
pT4: Extraocular tumor extension which includes sites as per American Joint Committee on Cancer 6th Edition definition (retinoblastoma) |
Is a |
False |
pT4 category |
Inferred relationship |
Some |
|
pT4: Tumor invades adjacent structures (esophagus) |
Is a |
False |
pT4 category |
Inferred relationship |
Some |
|
pT4: Tumor perforates the visceral peritoneum or directly invades other organs or structures (small intestine) |
Is a |
False |
pT4 category |
Inferred relationship |
Some |
|
pT4: Tumor invades main portal vein or hepatic artery or invades two or more extrahepatic organs or structures (gallbladder) |
Is a |
False |
pT4 category |
Inferred relationship |
Some |
|
pT4 (IVA): Tumor invades mucosa of the bladder or rectum and/or extends beyond the true pelvis (bullous edema is not sufficient evidence to classify a tumor as T4) (TNM category and FIGO stage) (vagina) |
Is a |
False |
pT4 category |
Inferred relationship |
Some |
|
pT4 (IVA): Tumor invades any of the following: upper urethra, bladder mucosa, rectal mucosa, or is fixed to the pubic bone (TNM category and FIGO stage) (vulva) |
Is a |
False |
pT4 category |
Inferred relationship |
Some |
|
pT4: Tumor invades any of the following: main portal vein or its branches bilaterally, common hepatic artery, or other adjacent structures, such as the colon, stomach, duodenum, or abdominal wall (extrahepatic bile ducts) |
Is a |
False |
pT4 category |
Inferred relationship |
Some |
|
pT4: Tumor involves any of the ipsilateral pleural surfaces plus additional sites as by American Joint Committee on Cancer 6th Edition definition (thoracic mesothelioma) |
Is a |
False |
pT4 category |
Inferred relationship |
Some |
|
pT4b: Tumor invades prevertebral fascia or encases carotid artery or mediastinal vessels (thyroid) |
Is a |
False |
pT4 category |
Inferred relationship |
Some |
|
pT4b: Extrathyroidal anaplastic carcinoma - surgically unresectable (anaplastic carcinoma) (thyroid) |
Is a |
False |
pT4 category |
Inferred relationship |
Some |
|
pT4a: Intrathyroidal anaplastic carcinoma - surgically resectable (anaplastic carcinoma) (thyroid) |
Is a |
False |
pT4 category |
Inferred relationship |
Some |
|
pT4a: Tumor of any size extending beyond the thyroid capsule to invade subcutaneous soft tissues, larynx, trachea, esophagus, or recurrent laryngeal nerve (thyroid) |
Is a |
False |
pT4 category |
Inferred relationship |
Some |
|
pT4b: Tumor involves masticator space, pterygoid plates, or skull base and/or encases internal carotid artery (oropharynx) |
Is a |
False |
pT4 category |
Inferred relationship |
Some |
|
pT4: Tumor with extraocular extension (iris) (uveal melanoma) |
Is a |
False |
pT4 category |
Inferred relationship |
Some |
|
pT4: Tumor more than 16 mm in greatest diameter and/or greater than 10 mm in maximum height (thickness) with extraocular extension (ciliary body and choroid) (uveal melanoma) |
Is a |
False |
pT4 category |
Inferred relationship |
Some |
|
pT4b: Tumor invades lateral pterygoid muscle, pterygoid plates, lateral nasopharynx, or skull base or encases internal carotid artery (oropharynx) |
Is a |
False |
pT4 category |
Inferred relationship |
Some |
|
pT4: Tumor directly invades other organs or structures and/or perforates visceral peritoneum (appendix) |
Is a |
False |
pT4 category |
Inferred relationship |
Some |
|
pT4b category |
Is a |
False |
pT4 category |
Inferred relationship |
Some |
|
pT4a category |
Is a |
False |
pT4 category |
Inferred relationship |
Some |
|
pT4c category |
Is a |
False |
pT4 category |
Inferred relationship |
Some |
|
pT4d category |
Is a |
False |
pT4 category |
Inferred relationship |
Some |
|