387381009: methotrexaat (substantie)

SNOMED CT Concept\Substance\...

\Substance categorized by disposition\Immunomodulator\Antimetabolite (substance)\Antifolate (substance)\Methotrexate (substance)

\Drug or medicament (substance)\Immunologic agent (substance)\Antifolate (substance)\Methotrexate (substance)
\Drug or medicament (substance)\Antineoplastic agent (substance)\Antimetabolite (substance)\Antifolate (substance)\Methotrexate (substance)

\Substance categorised by structure\Chemical\Chemical categorized by structure (substance)\Organic compound\Organic cyclic compound\Heterocyclic compound\Pteridine\Methotrexate (substance)

Status: current, Not sufficiently defined by necessary conditions definition status (core metadata concept). Date: 31-Jan 2003. Module: SNOMED CT core

Descriptions:

Expanded Value Set

Outbound Relationships	Type	Target	Active	Characteristic	Refinability	Group	Values
Methotrexate (substance)	Is a	Antimetabolite (substance)	false	Inferred relationship	Some
Methotrexate (substance)	Is a	Methotrexate and derivative	false	Inferred relationship	Some
Methotrexate (substance)	Is a	Anti-rheumatic agent	false	Inferred relationship	Some
Methotrexate (substance)	Has disposition (attribute)	Antimetabolite (disposition)	true	Inferred relationship	Some
Methotrexate (substance)	Is a	Antifolate (substance)	true	Inferred relationship	Some
Methotrexate (substance)	Is a	allergeen van geneesmiddel (substantie)	false	Inferred relationship	Some
Methotrexate (substance)	Is a	Pteridine	true	Inferred relationship	Some

Inbound Relationships	Type	Active	Source	Characteristic	Refinability	Group
Methotrexate measurement	Component	True	Methotrexate (substance)	Inferred relationship	Some	1
Methotrexate injection into tubal pregnancy	Direct substance	False	Methotrexate (substance)	Inferred relationship	Some	1
Methotrexate poisoning	Causative agent	True	Methotrexate (substance)	Inferred relationship	Some	1
Accidental methotrexate poisoning	Causative agent	False	Methotrexate (substance)	Inferred relationship	Some
Intentional methotrexate poisoning	Causative agent	False	Methotrexate (substance)	Inferred relationship	Some
intoxicatie door methotrexaat met onbekende intentie	Causative agent	False	Methotrexate (substance)	Inferred relationship	Some	1
Methotrexate adverse reaction	Causative agent	True	Methotrexate (substance)	Inferred relationship	Some	1
Allergy to methotrexate	Causative agent	False	Methotrexate (substance)	Inferred relationship	Some
Methotrexate overdose	Causative agent	True	Methotrexate (substance)	Inferred relationship	Some	1
Accidental methotrexate overdose	Causative agent	True	Methotrexate (substance)	Inferred relationship	Some	1
Intentional methotrexate overdose	Causative agent	True	Methotrexate (substance)	Inferred relationship	Some	1
overdosis methotrexaat met onbekende intentie	Causative agent	False	Methotrexate (substance)	Inferred relationship	Some	1
Plasma methotrexate measurement	Component	False	Methotrexate (substance)	Inferred relationship	Some	2
Serum methotrexate measurement	Component	False	Methotrexate (substance)	Inferred relationship	Some	2
Product containing precisely methotrexate 2.5 milligram/1 each conventional release oral tablet	Has active ingredient	False	Methotrexate (substance)	Inferred relationship	Some
Methotrexate 10 mg oral tablet	Has active ingredient	False	Methotrexate (substance)	Inferred relationship	Some
Methotrexate 2.5mg/mL injection solution 2mL vial	Has active ingredient	False	Methotrexate (substance)	Inferred relationship	Some
Methotrexate 25mg/mL injection solution 2mL vial	Has active ingredient	False	Methotrexate (substance)	Inferred relationship	Some
Methotrexate 25mg/mL injection solution 8mL vial	Has active ingredient	False	Methotrexate (substance)	Inferred relationship	Some
Methotrexate 25mg/mL injection solution 20mL vial	Has active ingredient	False	Methotrexate (substance)	Inferred relationship	Some
Methotrexate 25mg/mL injection solution 40mL vial	Has active ingredient	False	Methotrexate (substance)	Inferred relationship	Some
Methotrexate 25mg/mL injection solution 200mL vial	Has active ingredient	False	Methotrexate (substance)	Inferred relationship	Some
Methotrexate 100mg/mL injection solution 10mL vial	Has active ingredient	False	Methotrexate (substance)	Inferred relationship	Some
Methotrexate 100mg/mL injection solution 50mL vial	Has active ingredient	False	Methotrexate (substance)	Inferred relationship	Some
Methotrexate 12.5mg/mL infusion solution 30mL vial	Has active ingredient	False	Methotrexate (substance)	Inferred relationship	Some
Methotrexate 12.5mg/mL infusion solution 60mL vial	Has active ingredient	False	Methotrexate (substance)	Inferred relationship	Some
Methotrexate excretion measurement (procedure)	Component	True	Methotrexate (substance)	Inferred relationship	Some	1
Product containing precisely methotrexate 5 milligram/1 each conventional release oral tablet	Has active ingredient	False	Methotrexate (substance)	Inferred relationship	Some
Product containing precisely methotrexate 7.5 milligram/1 each conventional release oral tablet	Has active ingredient	False	Methotrexate (substance)	Inferred relationship	Some
Product containing precisely methotrexate 15 milligram/1 each conventional release oral tablet	Has active ingredient	False	Methotrexate (substance)	Inferred relationship	Some
Methotrexate lpf 25mg/mL preservative free injection	Has active ingredient	False	Methotrexate (substance)	Inferred relationship	Some
Product containing methotrexate (medicinal product)	Has active ingredient	True	Methotrexate (substance)	Inferred relationship	Some	1
Methotrexate sodium (substance)	Is a	False	Methotrexate (substance)	Inferred relationship	Some
Methotrexate 25mg/mL injection solution 10mL vial	Has active ingredient	False	Methotrexate (substance)	Inferred relationship	Some
Neurotoxicity caused by methotrexate (disorder)	Causative agent	True	Methotrexate (substance)	Inferred relationship	Some	1
Accidental methotrexate poisoning	Causative agent	True	Methotrexate (substance)	Inferred relationship	Some	1
Intentional methotrexate poisoning	Causative agent	True	Methotrexate (substance)	Inferred relationship	Some	1
Intravenous injection of methotrexate (procedure)	Direct substance	False	Methotrexate (substance)	Inferred relationship	Some	1
Methotrexate skin ulceration (disorder)	Causative agent	False	Methotrexate (substance)	Inferred relationship	Some
Intramuscular injection of methotrexate (procedure)	Direct substance	False	Methotrexate (substance)	Inferred relationship	Some	1
Intravenous injection of methotrexate (procedure)	Direct substance	False	Methotrexate (substance)	Inferred relationship	Some	1
Intravenous injection of methotrexate (procedure)	Direct substance	True	Methotrexate (substance)	Inferred relationship	Some	1
Intramuscular injection of methotrexate (procedure)	Direct substance	True	Methotrexate (substance)	Inferred relationship	Some	1
Methotrexate injection into tubal pregnancy	Direct substance	True	Methotrexate (substance)	Inferred relationship	Some	1
Measurement of methotrexate in cerebrospinal fluid (procedure)	Component	False	Methotrexate (substance)	Inferred relationship	Some	2
Subcutaneous injection of methotrexate (procedure)	Direct substance	False	Methotrexate (substance)	Inferred relationship	Some	1
Subcutaneous injection of methotrexate (procedure)	Direct substance	True	Methotrexate (substance)	Inferred relationship	Some	1
Allergy to methotrexate	Causative agent	True	Methotrexate (substance)	Inferred relationship	Some	1
Product containing methotrexate in parenteral dose form (medicinal product form)	Has active ingredient	True	Methotrexate (substance)	Inferred relationship	Some	1
Methotrexate-containing product in oral dose form	Has active ingredient	True	Methotrexate (substance)	Inferred relationship	Some	1
Cirrhosis of liver caused by methotrexate (disorder)	Causative agent	False	Methotrexate (substance)	Inferred relationship	Some	3
Product containing precisely methotrexate 2.5 milligram/1 each conventional release oral tablet	Has active ingredient	False	Methotrexate (substance)	Inferred relationship	Some	1
Product containing precisely methotrexate 2.5 milligram/1 each conventional release oral tablet	Has basis of strength substance (attribute)	False	Methotrexate (substance)	Inferred relationship	Some	1
Methotrexate 10 mg oral tablet	Has active ingredient	False	Methotrexate (substance)	Inferred relationship	Some	1
Methotrexate 10 mg oral tablet	Has basis of strength substance (attribute)	True	Methotrexate (substance)	Inferred relationship	Some	1
Product containing precisely methotrexate 5 milligram/1 each conventional release oral tablet	Has active ingredient	False	Methotrexate (substance)	Inferred relationship	Some	1
Product containing precisely methotrexate 5 milligram/1 each conventional release oral tablet	Has basis of strength substance (attribute)	False	Methotrexate (substance)	Inferred relationship	Some	1
Product containing precisely methotrexate 7.5 milligram/1 each conventional release oral tablet	Has active ingredient	False	Methotrexate (substance)	Inferred relationship	Some	1
Product containing precisely methotrexate 7.5 milligram/1 each conventional release oral tablet	Has basis of strength substance (attribute)	False	Methotrexate (substance)	Inferred relationship	Some	1
Product containing precisely methotrexate 15 milligram/1 each conventional release oral tablet	Has active ingredient	False	Methotrexate (substance)	Inferred relationship	Some	1
Product containing precisely methotrexate 15 milligram/1 each conventional release oral tablet	Has basis of strength substance (attribute)	False	Methotrexate (substance)	Inferred relationship	Some	1
Methotrexate 25mg/mL conventional release solution for injection	Has active ingredient	False	Methotrexate (substance)	Inferred relationship	Some
Product containing precisely methotrexate 5 milligram/1 each conventional release oral tablet	Has precise active ingredient	False	Methotrexate (substance)	Inferred relationship	Some	1
Product containing precisely methotrexate 2.5 milligram/1 each conventional release oral tablet	Has precise active ingredient	False	Methotrexate (substance)	Inferred relationship	Some	1
Product containing precisely methotrexate 7.5 milligram/1 each conventional release oral tablet	Has precise active ingredient	False	Methotrexate (substance)	Inferred relationship	Some	1
Methotrexate 10 mg oral tablet	Has precise active ingredient	True	Methotrexate (substance)	Inferred relationship	Some	1
Product containing precisely methotrexate 15 milligram/1 each conventional release oral tablet	Has precise active ingredient	False	Methotrexate (substance)	Inferred relationship	Some	1
Product containing precisely methotrexate (as methotrexate sodium) 5 milligram/2 milliliter conventional release solution for injection vial	Has basis of strength substance (attribute)	False	Methotrexate (substance)	Inferred relationship	Some	1
Product containing precisely methotrexate (as methotrexate sodium) 500 milligram/20 milliliter conventional release solution for injection vial	Has basis of strength substance (attribute)	False	Methotrexate (substance)	Inferred relationship	Some	1
Product containing precisely methotrexate (as methotrexate sodium) 1 gram/40 milliliter conventional release solution for injection vial	Has basis of strength substance (attribute)	False	Methotrexate (substance)	Inferred relationship	Some	1
Product containing precisely methotrexate (as methotrexate sodium) 1 gram/10 milliliter conventional release solution for injection vial	Has basis of strength substance (attribute)	False	Methotrexate (substance)	Inferred relationship	Some	1
Product containing precisely methotrexate (as methotrexate sodium) 5 gram/50 milliliter conventional release solution for injection vial	Has basis of strength substance (attribute)	False	Methotrexate (substance)	Inferred relationship	Some	1
Product containing precisely methotrexate (as methotrexate sodium) 50 milligram/2 milliliter conventional release solution for injection vial	Has basis of strength substance (attribute)	False	Methotrexate (substance)	Inferred relationship	Some	1
Product containing precisely methotrexate (as methotrexate sodium) 200 milligram/8 milliliter conventional release solution for injection vial	Has basis of strength substance (attribute)	False	Methotrexate (substance)	Inferred relationship	Some	1
Product containing precisely methotrexate (as methotrexate sodium) 5 gram/200 milliliter conventional release solution for injection vial	Has basis of strength substance (attribute)	False	Methotrexate (substance)	Inferred relationship	Some	1
Methotrexate sodium (substance)	Is modification of (attribute)	True	Methotrexate (substance)	Inferred relationship	Some
Lymphoproliferative disorder caused by methotrexate	Causative agent	True	Methotrexate (substance)	Inferred relationship	Some	1
Product containing only methotrexate (medicinal product)	Has active ingredient	True	Methotrexate (substance)	Inferred relationship	Some	1
Methotrexate only product in oral dose form	Has active ingredient	True	Methotrexate (substance)	Inferred relationship	Some	1
Product containing only methotrexate in parenteral dose form (medicinal product form)	Has active ingredient	True	Methotrexate (substance)	Inferred relationship	Some	1
Methotrexate (as methotrexate sodium) 100 mg/mL solution for injection	Has basis of strength substance (attribute)	True	Methotrexate (substance)	Inferred relationship	Some	1
Product containing precisely methotrexate (as methotrexate sodium) 25 milligram/1 milliliter conventional release solution for injection (clinical drug)	Has basis of strength substance (attribute)	True	Methotrexate (substance)	Inferred relationship	Some	1
Methotrexate (as methotrexate sodium) 2.5 mg/mL solution for injection	Has basis of strength substance (attribute)	True	Methotrexate (substance)	Inferred relationship	Some	1
Methotrexate skin ulceration (disorder)	Causative agent	True	Methotrexate (substance)	Inferred relationship	Some	1
Cirrhosis of liver caused by methotrexate (disorder)	Causative agent	True	Methotrexate (substance)	Inferred relationship	Some	1
Cirrhosis of liver caused by methotrexate (disorder)	Causative agent	True	Methotrexate (substance)	Inferred relationship	Some	2
Accelerated rheumatoid nodulosis caused by methotrexate (disorder)	Causative agent	True	Methotrexate (substance)	Inferred relationship	Some	2
Methotrexate (as methotrexate sodium) 2.5 mg oral tablet	Has basis of strength substance (attribute)	True	Methotrexate (substance)	Inferred relationship	Some	1
Product containing precisely methotrexate (as methotrexate sodium) 5 milligram/1 each conventional release oral tablet (clinical drug)	Has basis of strength substance (attribute)	True	Methotrexate (substance)	Inferred relationship	Some	1
Product containing precisely methotrexate (as methotrexate sodium) 10 milligram/1 each conventional release oral tablet (clinical drug)	Has basis of strength substance (attribute)	True	Methotrexate (substance)	Inferred relationship	Some	1
Product containing precisely methotrexate (as methotrexate sodium) 15 milligram/1 each conventional release oral tablet (clinical drug)	Has basis of strength substance (attribute)	True	Methotrexate (substance)	Inferred relationship	Some	1
Product containing precisely methotrexate (as methotrexate sodium) 7.5 milligram/1 each conventional release oral tablet (clinical drug)	Has basis of strength substance (attribute)	True	Methotrexate (substance)	Inferred relationship	Some	1
Methotrexate (as methotrexate sodium) 20 mg/mL solution for injection	Has basis of strength substance (attribute)	True	Methotrexate (substance)	Inferred relationship	Some	1
Product containing precisely methotrexate (as methotrexate sodium) 50 milligram/1 milliliter conventional release solution for injection (clinical drug)	Has basis of strength substance (attribute)	True	Methotrexate (substance)	Inferred relationship	Some	1
Product containing precisely methotrexate 25 milligram/1 milliliter conventional release solution for injection (clinical drug)	Has precise active ingredient	True	Methotrexate (substance)	Inferred relationship	Some	1
Product containing precisely methotrexate 25 milligram/1 milliliter conventional release solution for injection (clinical drug)	Has basis of strength substance (attribute)	True	Methotrexate (substance)	Inferred relationship	Some	1
Methotrexate 50 mg/mL solution for injection	Has precise active ingredient	True	Methotrexate (substance)	Inferred relationship	Some	1
Methotrexate 50 mg/mL solution for injection	Has basis of strength substance (attribute)	True	Methotrexate (substance)	Inferred relationship	Some	1
Methotrexate therapy (procedure)	Direct substance	True	Methotrexate (substance)	Inferred relationship	Some	1
Measurement of methotrexate in cerebrospinal fluid (procedure)	Component	True	Methotrexate (substance)	Inferred relationship	Some	1
Serum methotrexate measurement	Component	True	Methotrexate (substance)	Inferred relationship	Some	1

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Reference Sets

Dutch pathology simple reference set (foundation metadata concept)

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Id	Description	Lang	Type	Status	Case?	Module
1461559012	Methotrexate (substance)	en	Fully specified name	Active	Entire term case insensitive (core metadata concept)	SNOMED CT core
1481477014	Methotrexate	en	Synonym (core metadata concept)	Active	Entire term case insensitive (core metadata concept)	SNOMED CT core
1492026011	Amethopterin	en	Synonym (core metadata concept)	Active	Entire term case insensitive (core metadata concept)	SNOMED CT core
3756239015	MTX - methotrexate	en	Synonym (core metadata concept)	Active	Entire term case sensitive (core metadata concept)	SNOMED CT core
4991241000146117	methotrexaat	nl	Synonym (core metadata concept)	Active	Entire term case insensitive (core metadata concept)	SNOMED CT Netherlands NRC maintained module (core metadata concept)
4991251000146119	methotrexaat (substantie)	nl	Fully specified name	Active	Entire term case insensitive (core metadata concept)	SNOMED CT Netherlands NRC maintained module (core metadata concept)
4991261000146116	MTX	nl	Synonym (core metadata concept)	Active	Entire term case sensitive (core metadata concept)	SNOMED CT Netherlands NRC maintained module (core metadata concept)